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Effects of losartan and enalapril at hypotensive and non-hypotensive doses on cardiac and renal interstitial matrix in hypertensive rats
No full textEndothelin-1 induces vasoconstriction in subcutaneous small resistance arteries of normotensive and hypertensive subjects mainly by stimulation of ETA receptors.
No full textEffects of candesartan cilexitil and enalapril on inflammatory markers of atherosclerosis in hypertensive patients with non insulin-dependent diabetes mellitus. Results of a comparative, multicentre, randomized, double blind, two parallel groups study
No full textEffects of candesartan cilexetil and enalapril on inflammatory markers of atherosclerosis in hypertensive patients with non-insulin-dependent diabetes mellitus.
No full textCirculating adhesion molecules may have a
prognostic significance as markers of endothelial damage.
Drugs which inhibit the renin–angiotensin system may be
effective in reducing circulating or tissue adhesion
molecules, albeit data available are scarce. The aim of the
study was to investigate the effects of an angiotensinconverting
enzyme (ACE) inhibitor, enalapril and a highly
selective angiotensin receptor blocker, candesartan
cilexetil, on circulating adhesion molecules in a large
sample of patients with non-insulin-dependent diabetes
mellitus (NIDDM). The study was comparative, multicenter,
randomized and double blind, with two parallel groups.
Patients and methods NIDDM patients with a diagnosis of
mild (grade 1) essential hypertension were included in the
study, at the end of a 2-week placebo run-in period. The
primary end-point of the study was to evaluate changes of
intercellular adhesion molecule-1 (ICAM-1) plasma levels
during treatment. The secondary end-points were: changes
in vascular cells adhesion molecule-1 (VCAM-1), von
Willebrand factor (vWF), fibrinogen and plasminogen
activator inhibitor-1 (PAI-1) circulating levels and of urinary
albumin excretion rate (AER) as well; 129 patients were
randomized: 66 in the candesartan group and 63 in the
enalapril group, 118 of them completed the scheduled
24-week treatment period.
Results Candesartan and enalapril equally reduced
circulating level of ICAM-1 and exerted comparable effects
on changes of other adhesion molecules and coagulation
factors. A similar blood pressure-lowering effect
was observed with the two drugs (candesartan: from
148/90 W 11/8 to 132/82 W 12/7 mmHg, P < 0.01,
enalapril: from 148/91 W 12/8 to 131/85 W 14/6 mmHg,
P < 0.01). Candesartan was more effective than enalapril
in the reduction of albuminuria (P < 0.05 between
treatments), although urinary protein excretion can be
considered normal in the majority of patients. The two
drugs were comparable in terms of adverse events
reported.
Conclusion Candesartan and enalapril showed similar
effects on blood pressure and on circulating adhesion
molecules. In this study urinary protein excretion was
reduced more by candesartan
The vasoconstriction induced by endothelin-1 in subcutaneous small resistance arteries of normotensive and hypertensive subjects is mediated mainly by ETA receptors.
No full textThe vasoconstriction induced by endothelin-1 in subcutaneous small resistance arteries of normotensive and hypertensive subjects is mediated mainly by ETA receptors.
No full textEndothelin-1 elicits vasoconstriction in subcutaneous small resistance arteries of normotensive and hypertensive subjects mainly through stimulation of ETA receptors.
No full textBioavailability of nitric oxide (NO) in subcutaneous small resistance arteries of patients with essential hypertensive.
No full textEndothelial and contractile function of small resistance artery from hypertensive and diabetic patients: effects of insulin
No full textChanges in small resistance artery structure of hypertensive and diabetic patients treated with candesartan or enalapril.
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