1,721,099 research outputs found
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Use of CONSORT Criteria for Reporting Randomized Controlled Trials in Pharmacy Journals
No full textClass of 2012 AbstractSpecific Aims: To explore whether publishing requirements for human-centered randomized control trials, particularly the CONSORT criteria, have any relationship to impact as measured by the Journal Citation Reports ™ Impact Factor. Methods: A worksheet was used to evaluate a methodically selected list of journals, including types of articles published, requirements of authors for human-focused randomized control trials, JCR Impact Factor and other JCR metrics for each specific journal title. A worksheet was filled out for each journal by each member of the research team and answers combined for consensus. Group means and SDs were calculated and the Student’s t-Test applied to values for selected journals. Main Results: 50 candidate pharmacy journals were identified and 41 met the criteria for publishing human-centered randomized control trials. Journals were grouped according to whether they required CONSORT or had other reporting requirements for human RCTs, or had no requirements for such studies. Few (6; 15%) pharmacy journals required authors to use CONSORT; and additional 15 (37%) journals provided as least some author guidelines similar to CONSORT. Pharmacy journals using CONSORT or other guidelines had a higher average impact factor (3.5; SD = 1.5) than did journals without guidelines (2.4; SD = 0.9; p = 0.007). Conclusions: There appears to be a statistical difference in average JCR metrics between journals which require specific RCT guidelines and those which do not. The use of reporting guidelines, such as CONSORT, by pharmacy journals is associated with increased impact as represented by JCR influence measures.This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Librarian and Clinical Instructor, Pharmacy Practice and Science, [email protected]
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Self-management of Pain Among Pharmacy Students
No full textClass of 2016 AbstractObjectives: The purpose of this study is to determine if pharmacy students are more likely to use pharmacological agents to manage pain and if men and women are equally likely to use pharmacological agents. Methods: Questionnaires were administered after a regularly scheduled class for first, second and third year pharmacy students. Data collected included a pain intensity rating, whether pain was acute or chronic, how the pain was managed (medication, exercise, etc.) and if pain interfered with activities. Results: A total of 218 students (41% men, 71% aged 19-25) participated; 70% reported acute pain, 16%, chronic pain, and 14%, no pain. Pain intensity was greater in the chronic pain group (5.8 ± 1.7) than in the acute pain group (5.0 ± 2.1; p = 0.028). Chronic pain respondents were more likely to use prescription NSAIDs, muscle relaxers, physical therapy, transdermal electrical nerve stimulation, steroid injections and beta blockers (p < 0.02). There were few differences between men and women; women used OTC NSAIDs and acetaminophen at higher rates than men (p < 0.02). Women also used two non-pharmacological strategies (changed position and relaxation) at higher levels than men (p < 0.02). Students with chronic pain reported more pain interference with daily and leisure activities (p < 0.005) and work (p = 0.003) than students in the acute pain group. Conclusions: Different strategies were used for pain management between acute and chronic pain participants, and also between both men and women. Students with chronic pain reported more interference with activities than those with acute pain.This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Librarian and Clinical Instructor, Pharmacy Practice and Science, [email protected]
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Publications and Presentations from PharmD Student Research Projects: A Systematic Review
No full textClass of 2015 AbstractObjectives: To conduct a systematic review of reports of pharmacy student research programs to describe publication and presentations resulting from the research. Methods: To be eligible for the systematic review, studies must have described student research programs in which students’ were required to collect, analyze, report or present findings and be reported in English. Candidate studies were screened and data extracted using standardized forms by two investigators independently with the final list identified by consensus. The primary outcome variables were extramural posters/presentations and publications. Data were summarized in tables. Results: A total of 6112 studies were screened and 14 studies were identified that described student research meeting inclusion criteria; two reports were from outside the United States. Two-thirds were reports of required projects and a third were elective projects. Required research projects were conducted on a wide variety of topics including clinical, practice, laboratory, public health, education and other topics. Elective research was focused on clinical practice, and laboratory topics. Components of the research process were not uniformly described. The terminal project requirement was usually a written report (57%) or a poster (29%). One program required a presentation. More than half (64%) of the student research programs reported that students presented extramural posters and half (57%) reported that publications resulted from student research. Conclusions: About half of the student research programs described in the literature indicated that student research resulted in extramural posters or presentations.This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Librarian and Clinical Instructor, Pharmacy Practice and Science, [email protected]
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Aerobic Exercise and its Effects on HbA1c and BMI in Patients With Type 2 Diabetes Mellitus: a Meta-Analysis
No full textClass of 2014 AbstractSpecific Aims: To assess the effect of aerobic exercise dose has on diabetes control monitoring parameter of HbA1c and BMI. Methods: Studies were found from previous studies and through a search of PubMed. These studies were screened for eligibility and data was extracted using a data extraction tool. The outcomes of HbA1c and BMI were analyzed using Comprehensive Meta-Analysis software and standardized mean difference (SMD) was used to assess the impact of different doses of exercise on the outcome measures. Variability was measured using the I2 statistic and publication bias was assessed. Main Results: Nineteen studies met inclusion criteria and were analyzed. Moderate dose aerobic exercise was found to have moderate effect in reducing HbA1c and BMI (p = 0.00 & 0.03 respectively). Low dose and high dose aerobic exercise were not to reduce HbA1c (p = 0.07 & 0.13) or BMI (p = 0.61 & 0.25). There was excess variation found in both the HbA1c analysis and the BMI analysis (I2 = 72.28 & 84.04 respectively). There was no publication bias found (Kendall’s tau = 0.809). Conclusion: Moderate dose aerobic exercise was effective in reducing HbA1c and BMI, while low dose and high dose aerobic exercise were not found to have a statistically significant effect on either HbA1c or BMI.This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Librarian and Clinical Instructor, Pharmacy Practice and Science, [email protected]
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Use of Dietary Supplements Among Pharmacy Students
No full textClass of 2015 AbstractObjectives: To compare the use of herbal and dietary supplements amongst pharmacy students to the use in the general population; assess knowledge and attitudes toward the use, and perceived effectiveness of herbal and dietary supplements. Methods: Paper questionnaires that were administered to the first-, second- and third-year students collected data about the herbal and dietary supplement use, knowledge, students’ attitudes towards the use of herbal and dietary supplements, as well as information about demographics and students’ work experience. Overall use was compared to the 2007 National Health Interview survey findings. Results: From a total of 179 students who responded, 52% indicated that they had ever used at least one product, which was greater than the 25%-use reported in the general population. Almost half (46%) of students indicated they had used fish oil/omega-3; about 38% used one or more of the other listed products. Students had limited knowledge on the use of herbal and dietary supplements. The average score on the side effects and indicated uses of selected dietary supplements was 50%; however, the third-year students scored significantly higher than the first-year students (p < 0.001). Students rated dietary supplements as not essential for health, but thought that the education on dietary supplements was inadequate. Conclusions: About half (52%) of this sample of pharmacy students reported having ever used dietary supplements compared to only 25% of the general population. However, students seemed to have limited knowledge of dietary supplements and thought more education was needed.This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Librarian and Clinical Instructor, Pharmacy Practice and Science, [email protected]
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Meta-analysis of Weight Change in the Placebo Groups of Lorcaserin and Phentermine/Topiramate Trials from the FDA Database
No full textClass of 2015 AbstractObjectives: To retrieve data from RCTs for lorcaserin and phentermine and topiramate combination on weight loss, BMI reduction, and other factors from the placebo groups and to determine if there is a difference in weight loss between those groups. Methods: Design: Meta-analysis Inclusion criteria: RCTs that compared lorcaserin or phentermine/topiramate to placebo as submitted to the FDA and posted to the FDA website. The studies needed to report weight loss or BMI values at baseline and post-treatment. Measures: The primary dependent variables were weight lost in kilograms, change in BMI, and percent who achieved 5% weight loss in the placebo arm. Data Collection: A standardized data collection form was used to extract data from the selected trials. Data was independently extracted by 3 researchers and discrepancies were resolved by consensus. Data Analysis: Data was analyzed by constructing a forest plot of the amount of weight lost in the placebo arm stratified by type of drug. A funnel plot and Kendall’s tau were used to assess publication bias. Heterogeneity was assessed with I2. The a priori alpha level was 0.05. Results: Statistically significant weight loss was achieved in the placebo arm in all 6 RCTs Weight loss was consistent across type of study Lorcaserin studies, mean = 2.42 kg Phentermine/topiramate studies, mean = 2.14 kg Overall rate of 5% weight loss was 0.32 No data was reported on actual caloric intake or actual quantity of exercise Funnel plot and Kendall’s tau (p = 0.85) indicated there was no publication bias There was heterogeneity in the lorcaserin studies resulting from one study reporting a large effect Conclusions: Participants in the placebo arm lost weight with monthly counseling on calorie intake and exercise, however, actual caloric intake or quantity of exercise that resulted in the weight loss is unknown.This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Librarian and Clinical Instructor, Pharmacy Practice and Science, [email protected]
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The Association of Vitamin D Supplementation with Type I Diabetes in New Born and Pregnant Mothers: A systematic Review
No full textClass of 2013 AbstractSpecific Aims: To assess whether vitamin D supplementation is associated with a reduced risk of type I diabetes in infants. Methods: This study was a systematic review using Pubmed, Google Scholar and reference lists of retrieved articles. Only randomized controlled trials and prospective observational studies were considered for this study. Data were extracted and organized into tables. The data were organized into three categories; study characteristics, patient characterisitics and study outcomes. The main outcomes were association of type I diabetes with vitamin D deficiency and identify the proper dose of vitamin D in pediatric population. Main Results: A total of 3 randomized controlled trials and 2 prospective observational studies were found that met the inclusion criteria; retrospective studies and case control studies were excluded. Combining all studies, no association was seen between vitamin D supplement and control group. Most of the randomized control studies have not shown a statistically significant association between Hb A1C, C-Peptide and vitamin D level with type I diabetes. The Gabbay et al. study showed that vitamin D serum concentrations (25(OH)D3) in the cholecalciferol and placebo groups were not significant at 6 ( P= 0.93),12( P= 0.81), and 18 (P= 0.53) months of follow up. The vitamin D concentration was increased during the 6 months period compared to baseline value (Basal: 26.34ng/ml vs 6 months: 60.88 ng/mL; P 30 ng/ml but none support the use of vitamin D in prevention of type I diabetes. Given the lack of data to support the use of vitamin D to reduce the risk of type I diabetes, vitamin D supplementation should be used to supplement vitamin D levels in children not exposed to adequate sunlight. There is no clear recommendation dose for treatment and prevention of vitamin D supplementation for pediatric patients. Therefore, monitoring and routine measurements of vitamin D by physician can play an important role. More randomized control trials with large sample would be needed to answer all of the unknown questions regarding the dosage of vitamin D supplement.This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Librarian and Clinical Instructor, Pharmacy Practice and Science, [email protected]
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Effects of Exenatide Twice Daily and Once Weekly on Weight Loss
No full textClass of 2013 AbstractSpecific Aims: To determine the effectiveness of exenatide twice daily (ExBID) versus exentatide once weekly (ExQW) on weight loss in type II diabetes. Methods: This study was a meta-analysis. The studies used came from the PubMed database and Cochrane Reviews. To be included in the meta-analysis, studies must have been randomized controlled trials comparing ExBID to ExQW or drug to placebo. The studies that reported weight loss and/or HbA1C were included. Studies that included participants <18 years of age or compared only one dose of exenatide with other anti-diabetic medication without comparing to placebo were excluded. There were 13 studies that met the inclusion criteria and were included in the meta-analysis. The primary outcome was weight loss, and the secondary outcome was HbA1C levels. Meta-analysis was used to synthesize data. Main Results: The difference between ExQW and ExBID on weight loss was not statistically significant (standardized mean difference (SMD) = -0.71, CI -0.84 to -0.58 in ExQW vs SMD = 0.82, CI -1.02 to -0.62 in ExBID; p =0.36). The effect of ExQW on A1C was significantly larger than ExBID (SMD = -1.69 vs -1.07 respectively; p < 0.01). The variability was very high in the ExBID group (69% - 81%) compared to ExQW group (0%). Kendall’s tau was significant (p= 0.01) indicating that there may be publication bias. Conclusion: There is no difference in effect of weight loss between ExQW and ExBID group. Both dosages significantly improve A1C; however, ExBID has larger impact on A1C compared to ExBID.This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Librarian and Clinical Instructor, Pharmacy Practice and Science, [email protected]
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Pharmacists Use of Over-the-Counter Vitamins, Minerals, and Herbal Supplements
No full textClass of 2016 Abstract & ReportSpecific Aims: This study aims to evaluate the use and rationale of dietary supplement use by pharmacists and to assess whom pharmacists are recommending them to. Methods: Arizona licensed pharmacists were surveyed using Qualtrics software. The survey consisted of questions starting with listing common vitamin, mineral and herbal products used personally. Respondents were then asked to indicate a purpose for use and if they would recommend personally used products to patients, family or friends. Demographics such as area of practice, gender and age were also collected. Data were analyzed by calculating summary frequency and percentages with a priori alpha level of 0.05. Main Results: Of the 10,899 surveys sent, 528 respondents completed the survey. The average respondent age was 46.6 ± 14.4, 40% were male and 42% practiced in community pharmacy Overall use was: multivitamin (95.54%), vitamin C (78.24%), vitamin D (73.31%), calcium (73.13%), and B vitamin(s) (70.03%). The most common reasons for use were “general health and wellness” and “to treat or cure a specific disease or health problem.” Overall use of supplements was lower; 58% for fish oil while only 25% used chondroitin. More community pharmacists used all types of dietary supplements (p < 0.05). Most pharmacists would recommend the products to patients. Conclusions: (39) Pharmacists use dietary supplements at rates similar to the general public and would recommend the noted products to patients. This is particularly relevant because existing well designed studies evaluating efficacy and safety of the products in question are limited.This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Librarian and Clinical Instructor, Pharmacy Practice and Science, [email protected]
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Exercise and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Exercise Duration and Intensity and Their Effects on HbA1c and BMI
No full textClass of 2013 AbstractSpecific Aims: To assess the impact that exercise-type has on diabetes control through improvement in monitoring parameters such as hemoglobin A1c and fasting blood glucose. Methods: Studies were selected using a study inclusion tool and then data was extracted using the data extraction tool. The primary outcomes assessed were BMI and HbA1c. The standardized mean difference (SMD) was the main summary measure and the I2 statistic ¬¬¬¬¬¬was used to assess variability among the studies. Main Results: Ten studies met inclusion criteria (Total N = 1,787). The age range of patients was 40-66 years old with equal amounts of male and female participants. Aerobic and resistance exercise were effective (p < 0.01) in reducing A1c; Tai Chi was not (p = 0.50). Aerobic exercise did not have a significant effect on BMI (p = 0.07), however Tai Chi and Resistance exercise did (p<0.04). Conclusion: Aerobic and resistance exercise produced a significant reduction in HbA1c, whereas Tai Chi did not. The non-significant impact aerobic exercise had on BMI was probably due to large variation between the studies. No significant differences were found between the different forms of exercise and their overall impact on diabetes control. Based upon the data incorporated in this meta-analysis, it is reasonable for patients with diabetes mellitus type 2 to use aerobic or resistance exercise to improve their HbA1C. However, it remains to be seen whether recommending specific exercise types over others will provide increased benefit.This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Librarian and Clinical Instructor, Pharmacy Practice and Science, [email protected]
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