109,192 research outputs found
Letter from G. T. Skinner to Theophilus Brown Larimore
No full textLetter from G. T. Skinner to Theophilus Brown Larimore. The three-page handwritten letter is dated 19 February 1913. A transcript of the letter is included in the item PDF
Accounting Hall of Fame 2000 induction: Ross M. Skinner
No full textFor the induction of Robert M. Skinner: Remarks by Robert T. Rutherford, The Canadian Institute of Chartered Accountants; Citation prepared by Daniel L. Jensen, The Ohio State University, Read by Robert T. Rutherford; Response by Ross M. Skinner, Clarkson Gordo
Data from manuscript “Low levels of SIV-specific CD8+ T cells in germinal centers characterizes acute SIV infection”
No full textData file contains the animal information and quantitative image analysis results from our study of the early SIV-specific CD8 T cell responses during SIV infection.CD8+ T cells play an important role in controlling of HIV and SIV infections. However, these cells are largely excluded from B cell follicles where HIV and SIV producing cells concentrate during chronic infection. It is not known, however, if antigen-specific CD8+ T cells are excluded gradually as pathogenesis progresses from early to chronic phase, or this phenomenon occurs from the beginning infection. In this study we determined that SIV-specific CD8+ T cells were largely excluded from follicles during early infection, we also found that within follicles, they were entirely absent in 60% of the germinal centers (GCs) examined. Furthermore, levels of SIV-specific CD8+ T cells in follicular but not extrafollicular areas significantly correlated inversely with levels of viral RNA+ cells. In addition, subsets of follicular SIV-specific CD8+ T cells were activated and proliferating and expressed the cytolytic protein perforin. These studies suggest that a paucity of SIV-specific CD8+ T cells in follicles and complete absence within GCs during early infection may set the stage for the establishment of persistent chronic infection. This record shares the data collected by this study.This work was supported by a Public Health Service grant from the National Institutes of Health (grant R01AI096966), by Wisconsin National Primate Research Center grant P51OD011106/P51RR000167, by the Wisconsin National Primate Research Center Pathology and Scientific Protocol Implementation Units, NIH Tetramer Core Facility (contract HHSN272201300006C), by the NIH Nonhuman Primate Reagent Resource (grant R24 RR016001), and by the National Institute of Allergy and Infectious Diseases (contract HHSN 2722000900037C).Skinner, Pamela J.. (2018). Data from manuscript “Low levels of SIV-specific CD8+ T cells in germinal centers characterizes acute SIV infection”. Retrieved from the University Digital Conservancy, https://doi.org/10.13020/nss2-h623
Skinner, G T, VX43478
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/417252Surname: SKINNER. Given Name(s) or Initials: G T. Military Service Number or Last Known Location: VX43478. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 42337.239946
Item: [2016.0049.49513] "Skinner, G T, VX43478
Skinner, T R (Thomas Roy), SX10637
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/417250Surname: SKINNER. Given Name(s) or Initials: T R (THOMAS ROY). Military Service Number or Last Known Location: SX10637. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 32314.239944
Item: [2016.0049.49511] "Skinner, T R (Thomas Roy), SX10637
Personal models of diabetes in relation to self-care, well-being and glycemic control: a prospective study in adolescence
No full textOBJECTIVE: Personal models of diabetes have been shown to be proximal determinants of self-care behavior in adults with diabetes, both cross-sectionally and prospectively. This study set out to test the predictive utility of this approach in adolescents with diabetes.RESEARCH DESIGN AND METHODS: Participants were recruited from four regional hospitals in southern England (n = 54). They completed questionnaires assessing diabetes self-care, well-being, and personal models of diabetes (perceived impact, perceived seriousness, and short- and long-term treatment effectiveness) at baseline and 1-year follow-up. GHb assays performed as part of the patients’ usual diabetes care were used to assess glycemic control.RESULTS: After controlling for baseline anxiety, change in perceived impact of diabetes prospectively predicted adolescents’ anxiety (ß = -0.21; t = -2.65; P < 0.01). After controlling for baseline dietary self-care, change in perceived effectiveness of the diabetes treatment regimen to control diabetes predicted dietary self-care (ß = -0.39; t = -3.28; P < 0.0005). Poorer dietary self-care and being female were predictive of poorer glycemic control (r2 = 0.29; F = 2.74; P < 0.005).CONCLUSIONS: This study provides further support for the role of personal models of illness in determining responses to illness. As adolescents take responsibility for the management of their diabetes, parents, clinicians, educators, and interventionists should consider these adolescents’ beliefs about their diabetes and its treatment as key factors influencing self-care, emotional well-being, and glycemic control
Skinner - McNab
No full textOblique aerial view of Skinner - McNabImage is situated at 44.633° North (Latitude), 81.076° West (Longitude)
Recurrent diabetic ketoacidosis: causes, prevention and management
No full textLongitudinal studies indicate that 20% of paediatric patients account for 80% of all admissions for diabetic ketoacidosis (DKA). The frequency of DKA peaks during adolescence and, although individuals generally go into remission, they may continue to have bouts of recurrent DKA in adulthood. The evidence for insulin omission being the behavioural precursor to recurrent DKA is reviewed and discussed. Thereafter the range of possible psychosocial causes is explored and the evidence for each discussed. Approaches to assessing the individual and their family to identify aetiology and therefore appropriate intervention are considered and treatment options reviewed. Finally, the paper examines potential risk factors for recurrent DKA, possible strategies for identifying these early and how to use these assessments to prevent subsequent recurrent DKA
Anti-CAR antibody response in SIV infected rhesus macaques
No full textExcel files of flow cytometry data and statistics to support manuscript figuresT cells expressing a simian immunodeficiency (SIV)-specific chimeric antigen receptor (CAR) and the follicular homing molecule, CXCR5, were infused into antiretroviral therapy (ART) suppressed, SIV-infected rhesus macaques to assess their ability to localize to the lymphoid follicle and control the virus upon ART interruption. The cells did not persist in the animals beyond 28 days. Development of anti-CAR antibodies could be responsible for the lack of persistence. Potential antigenic sites on the anti-SIV CAR used in these studies included domains 1 and 2 of CD4, the carbohydrate recognition domain (CRD) of mannose-binding lectin (MBL), and an extracellular domain of the costimulatory molecule, CD28, along with short linker sequences. Using a flow cytometry based assay and target cells expressing the CAR/CXCR5 construct, we examined the serum of the CAR T-cell treated animals to determine that the animals had developed an anti-CAR antibody response after infusion. Binding sites for the anti-CAR antibodies were identified by using alternative CARs transduced into target cells and by preincubation of the target cells with a CD4 blocking antibody. All of the treated animals developed antibodies in their serum that bound to CAR-T cells and the majority were capable of inducing an ADCC response. The CD4 antibody-blocking assay suggests that the dominant immunogenic components of this CAR are the CD4 domains with a possible additional site of the CD28 domain with its linker.This research was supported by: 5R01AI096966-06S1 (PS, and EB), 1UM1AI26617 (PS, and EB), P51OD011106/ P51RR000167 (ER), R01AI143380 (PS and EB), 1UM14126617 (PS and EC), training grant 5- T32 AI 55433 (EKC) as well as funds provided by the NIAID Division of Intramural Research (https:// www.niaid.nih.gov) and the NIH Intramural AIDS Targeted Antiviral Program (https://irp.nih.gov) (EB).Davey, Brianna, C; Pampusch, Mary, S; Cartwright, Emily, K; Abdelaal, Hadia, M; Rakasz, Eva, G; Rendahl, Aaron; Berger, Edward, A; Skinner, Pamela, J. (2022). Anti-CAR antibody response in SIV infected rhesus macaques. Retrieved from the University Digital Conservancy, https://doi.org/10.13020/d3e7-wt82
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