6 research outputs found
Transforming Chicken Feather Waste into Feather Protein Hydrolysate Using a Newly Isolated Multifaceted Keratinolytic Bacterium Chryseobacterium sediminis RCM-SSR-7
No full textAnticarcinogenic and Antioxidant Action of an Edible Aquatic Flora Jussiaea repens L. Using In Vitro Bioassays and In Vivo Zebrafish Model
No full textOxidative stress is the major cause of many health conditions, and regular consumption of antioxidants helped to encounter and prevent such oxidative stress-related diseases. Due to safety concerns over long-term uses of synthetic antioxidants, natural antioxidants are more preferred. The purpose of this study is to investigate the antioxidant and anticancer activities of Jussiaea repens L., a wild edible flora found in Manipur, India. The antioxidant activity was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), Ferric reducing antioxidant power (FRAP) assay and DNA-nicking assay. The anticancer activity was tested using five cancer lines viz., SKOV3 cells (ovarian), HeLa (cervical), MDA-MB-231 (breast), PANC-1 (pancreatic), and PC3 (prostate). The toxicity, developmental effect, antiproliferative activity was further tested using zebrafish embryos. The methanolic plant extract had higher polyphenol content than flavonoids. The in vitro study demonstrated a promising antioxidant capacity and DNA protection ability of this plant. The extract also showed cytotoxic activity against SKOV3, HeLa, MDA-MB-23, and PANC-1 cancer cell lines. The in vivo studies on zebrafish embryos demonstrated the extract’s ability to suppress the developmental process and elicited more cytotoxicity to cancer cells than developing zebrafish embryos. Moreover, the in vivo studies on zebrafish embryos also indicated the antiproliferative activity of J. repens L. extract
Therapeutic potential of endophytic bacteria from ethnomedicinal plants used by the traditional healers of North East India
No full text618-628North East Indian Himalayan Region (NEIHR) is endowed with a diverse ecosystem. The indigenous people of this region have good traditional knowledge to combat various diseases and physical ailments using ethnomedicinal plants that were gained through experience over years. Some of the plants have been incorporated in the conventional medicines. However, many of the plants have not been scientifically explored since they remain endemic to a particular region and the traditional healers kept it as secret knowledge. The majority of the endophyte of NEIHR belongs to genus Acinetobacter, Bacillus, Microbacterium, Pseudomonas, Serratia, and Streptomyces. Endophytic bacteria exhibit antimicrobial activities against important human pathogens such as Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica, Streptococcus pyogenes, Staphylococcus aureus, etc. Bioactive strains display potential anticancer and antioxidant activities. This review also incorporates some of the potential unexplored medicinal plants used by the ethnic population of this region for treating common diseases and the importance of exploring bioactive compounds from the associated bacteria. It will also highlight the prospects of discovering novel bioactive compounds that will have a new and novel mechanism of actions for combating the drug resistant pathogens
DNA protection ability, antihyperglycemic potential and <i>in-vivo</i> toxicity assessment of arrowleaf tearthumb (<i>Persicaria sagittata</i> L.), a neglected aquatic plant species of Eastern Asia
No full textPersicaria sagittata L. (common name arrowleaf tearthumb, American) is an herbaceous edible plant with characteristics sessile leaves mainly found in wetland areas of North America and Eastern Asia. In Eastern Himalayan Region of India, the ethnic communities consumed this plant as vegetables. The present investigation suggests the plant is endowed with bioactive compounds having potential DNA protection ability and antihyperglycemic activity. The DNA nicking assay revealed that the methanolic extract of this plant has the potential to protect plasmid DNA against hydroxyl damage. The α-glucosidase and α-amylase inhibitory assay of this methanolic extract suggest more effectiveness in inhibition of α-amylase than the α-glucosidase. Further, proximate composition, micronutrient, total phenolic and flavonoid content of this underutilised aquatic plant was determined. And lastly the in-vivo cytotoxicity study of Persicaria sagittata L. plant extract suggest that the plant is less toxic to in-vivo system.</p
Therapeutic potential of endophytic bacteria from ethnomedicinal plants used by the traditional healers of North East India
Get PDFNorth East Indian Himalayan Region (NEIHR) is endowed with a diverse ecosystem. The indigenous people of this region have good traditional knowledge to combat various diseases and physical ailments using ethnomedicinal plants that were gained through experience over years. Some of the plants have been incorporated in the conventional medicines. However, many of the plants have not been scientifically explored since they remain endemic to a particular region and the traditional healers kept it as secret knowledge. The majority of the endophyte of NEIHR belongs to genus Acinetobacter, Bacillus, Microbacterium, Pseudomonas, Serratia, and Streptomyces. Endophytic bacteria exhibit antimicrobial activities against important human pathogens such as Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica, Streptococcus pyogenes, Staphylococcus aureus, etc. Bioactive strains display potential anticancer and antioxidant activities. This review also incorporates some of the potential unexplored medicinal plants used by the ethnic population of this region for treating common diseases and the importance of exploring bioactive compounds from the associated bacteria. It will also highlight the prospects of discovering novel bioactive compounds that will have a new and novel mechanism of actions for combating the drug resistant pathogens.
