6,512 research outputs found
Imaging nuclear, endoplasmic reticulum and plasma membrane events in real time
No full textLive cell imaging can provide important information on cellular dynamics; however, the full utilisation of this technology has been hampered by the limitations of imaging reagents. Metal-based complexes have the potential to overcome many of the issues common to many current imaging agents. The rhenium (I)-based complex fac-[Re(CO)3 (1,10-phenanthroline)(4-pyridyltetrazolate)], herein referred to as ReZolve-ER(™) , shows promise as a live cell imaging agent with rapid cell uptake, low cytotoxicity, resistance to photobleaching and compatibility with multicolour imaging. ReZolve-ER(™) localised to the nuclear membrane/endoplasmic reticulum (ER) and allowed the detection of exocytotic events at the plasma membrane. Thus, we present a new imaging agent for monitoring live cell events in real time, which is ideal for imaging either short- or long-time courses.Christie A. Bader, Alexandra Sorvina, Peter V. Simpson, Phillip J. Wright, Stefano Stagni, Sally E. Plush, Massimiliano Massi and Douglas A. Brook
A clinical and molecular investigation of two families with Simpson-Golabi-Behmel syndrome
No full textIncludes abstract (p. 30-32).
Includes bibliographical references
Introduction to the special issue
No full textDr Zach Simpson and Prof Peter Looker, the editors of this second, special issue of SOTL in the South, contextualise the papers in the issue in relationship to one another. These articles were select for double-blind peer-review and publication after being presented at the SOTL in the South conference in July 2017 in Johannesburg, South Africa.
How to cite this editorial:
SIMPSON, Zach; LOOKER, Peter. Editorial: introduction to the special issue. Scholarship of Teaching and Learning in the South. v. 2, n. 1, p. 1-3, Apr. 2018. Available at: http://sotl-south-journal.net/?journal=sotls&page=article&op=view&path%5B%5D=52
This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
 
Notes on Peter Karpovich for admission to Springfield College, c. 1925
No full textThese are notes on Peter V. Karpovich that were created, mostly likely, as part of his admissions process to Springfield College, c. 1925. The author or writer of these pages is not identified. Nor is it identified as to how, whether in a meeting or an interview or just from reading information, these notes were created. The notes are written in abreviations and in short fragments. The notes basically outline facts about his life, including age, family, education history, medical practice, present living arrangements, experience with the Young Men's Christian Associaation (YMCA), and experience in teaching Physical Education. Finally they also talk about his arrival in the United States, his desires for work/education at Springfield College., and his prospects of returning to Russia after his degree.For more information on Peter V. Karpovich, see: https://springfield.as.atlas-sys.com/agents/people/57
A molecular probe for the detection of polar lipids in live cells
No full textData source: Supporting Information, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161557#sec017Lipids have an important role in many aspects of cell biology, including membrane architecture/compartment formation, intracellular traffic, signalling, hormone regulation, inflammation, energy storage and metabolism. Lipid biology is therefore integrally involved in major human diseases, including metabolic disorders, neurodegenerative diseases, obesity, heart disease, immune disorders and cancers, which commonly display altered lipid transport and metabolism. However, the investigation of these important cellular processes has been limited by the availability of specific tools to visualise lipids in live cells. Here we describe the potential for ReZolve-L1™ to localise to intracellular compartments containing polar lipids, such as for example sphingomyelin and phosphatidylethanolamine. In live Drosophila fat body tissue from third instar larvae, ReZolve-L1™ interacted mainly with lipid droplets, including the core region of these organelles. The presence of polar lipids in the core of these lipid droplets was confirmed by Raman mapping and while this was consistent with the distribution of ReZolve-L1™ it did not exclude that the molecular probe might be detecting other lipid species. In response to complete starvation conditions, ReZolve-L1™ was detected mainly in Atg8-GFP autophagic compartments, and showed reduced staining in the lipid droplets of fat body cells. The induction of autophagy by Tor inhibition also increased ReZolve-L1™ detection in autophagic compartments, whereas Atg9 knock down impaired autophagosome formation and altered the distribution of ReZolve-L1™. Finally, during Drosophila metamorphosis fat body tissues showed increased ReZolve-L1™ staining in autophagic compartments at two hours post puparium formation, when compared to earlier developmental time points. We concluded that ReZolve-L1™ is a new live cell imaging tool, which can be used as an imaging reagent for the detection of polar lipids in different intracellular compartments.Christie A. Bader, Tetyana Shandala, Elizabeth A. Carter, Angela Ivask, Taryn Guinan, Shane M. Hickey, Melissa V. Werrett, Phillip J. Wright, Peter V. Simpson, Stefano Stagni, Nicolas H. Voelcker, Peter A. Lay, Massimiliano Massi, Sally E. Plush, Douglas A. Brook
Zechariah 9-14 as the substructure of 1 Peter’s eschatological program
No full textThe principal aim of this study is to discern what has shaped the author of 1 Peter to regard Christian suffering as a necessary (1.6) and to-be-expected (4.12) component of faithful allegiance to Jesus Christ. Most research regarding suffering in 1 Peter has limited the scope of inquiry to two particular aspects—its cause and nature, and the strategies that the author of 1 Peter employs in order to enable his addressees to respond in faithfulness. There remains, however, the need for a comprehensive explanation for the source that has generated 1 Peter’s theology of Christian suffering. If Jesus truly is the Christ, God’s chosen redemptive agent who has come to restore God’s people, then how can it be that Christian suffering is a necessary part of discipleship after his coming, death and resurrection? What led the author of 1 Peter to such a startling conclusion, which seems to runs against the grain of the eschatological hopes and expectations of Jewish restoration ideology?
This thesis analyzes the appropriation of shepherd and fiery trials imagery,
and argues that the author of 1 Peter is dependent upon Zechariah 9-14 for his
theology of Christian suffering. Said in another way, the eschatological program of
Zechariah 9-14, read through the lens of the Gospel, functions as the substructure
for 1 Peter’s eschatology and thus its theology of Christian suffering.
In support of this hypothesis, this study highlights the fact that Zechariah 9-
14 was available and appropriated in early Christianity, in particular in the Passion
Narrative tradition; that the shepherd imagery of 1 Pet 2.25 is best understood
within the milieu of the Passion Narrative tradition, and that it alludes to the
eschatological program of Zechariah 9-14; that the fiery trials imagery found in 1
Peter 1.6-7 and 1 Pet 4.12 is distinct from that which we find in Greco-Roman and OT
wisdom sources, and that it shares exclusive parallels with some unique features of
the eschatological program of Zechariah 9-14; that Zechariah 9-14 offers a more
satisfying explanation for the modification of Isa 11.2 in 1 Pet 4.14, the transition
from 4.12-19 to 5.1-4, why Peter has oriented his letter with the term διασπορά,
and why he has described his addresses as οἶκος τοῦ θεοῦ; and finally that 1 Peter
contains an implicit foundational narrative that shares distinct parallels with the
eschatological program of Zechariah 9-14.
We can conclude that 1 Peter offers a unique vista into the way in which at
least one early Christian witness came to understand and to communicate the fact
that Christian suffering was a necessary feature of faithful allegiance to Jesus Christ
Uranium: mineralogy, geochemistry, and the environment Reviews in mineralogy ;, v. 38./ editors, Peter C. Burns & Robert J. Finch.
No full textIn English.Includes bibliographical references.Volume 38 of Reviews in Mineralogy provides detailed reviews of various aspects of the mineralogy and geochemistry of uranium. We have attempted to produce a volume that incorporates most important aspects of uranium in natural systems, while providing some insight into important applications of uranium mineralogy and geochemistry to environmental problems. The result is a blend of perspectives and themes: historical (Chapter 1), crystal structures (Chapter 2), systematic mineralogy and paragenesis (Chapters 3 and 7), the genesis of uranium ore deposits (Chapters 4 and 6), the geochemical behavior of uranium and other actinides in natural fluids (Chapter 5), environmental aspects of uranium such as microbial effects, groundwater contamination and disposal of nuclear waste (Chapters 8, 9 and 10), and various analytical techniques applied to uranium-bearing phases (Chapters 11-14).This volume was written in preparation for a short course by the same title, sponsored by the Mineralogical Society of America, October 22 and 23, 1999 in Golden, Colorado, prior to MSA's joint annual meeting with the Geological Society of America.Ewing, Rodney C. -- Burns, Peter C. -- Finch, Robert / Murakami, Takashi -- Fayek, Mostafa / Kyser, T. Kurtis -- Murphy, William M. / Shock, Everett L. -- Plant, Jane A. / Simpson, Peter R. / Smith, Barry / Windley, Brian F. -- Janeczek, Janusz -- Suzuki, Yohey / Banfield, Jillian F. -- Abdelouas, Abdesselam / Lutze, Werner / Nuttall, H. Eric -- Wronkiewicz, David J. / Buck, Edgar C. -- Hanchar, John M. -- Čejka, Jiři -- Wolf, Stephen F. -- Hill, Frances C. Frontmatter -- COPYRIGHT -- ADDITIONAL COPIES -- FOREWORD -- PREFACE -- Mineralogy, Geochemistry and the Environment -- TABLE OF CONTENTS -- 1. Radioactivity and the 20th Century / 2. The Crystal Chemistry of Uranium / 3. Systematics and Paragenesis of Uranium Minerals / 4. Stable Isotope Geochemistry of Uranium Deposits / 5. Environmental Aqueous Geochemistry of Actinides / 6. Uranium Ore Deposits- Products of the Radioactive Earth / 7. Mineralogy and Geochemistry of Natural Fission Reactors in Gabon / 8. Geomicrobiology of Uranium / 9. Uranium Contamination in the Subsurface: Characterization and Remediation / 10. Uranium Mineralogy and the Geologic Disposal of Spent Nuclear Fuel / 11. Spectroscopic Techniques Applied to Uranium in Minerals / 12. Infrared Spectroscopy and Thermal Analysis of the Uranyl Minerals / 13. Analytical Methods for Determination of Uranium in Geological and Environmental Materials / 14. Identification of Selected Uranium-bearing Minerals and Inorganic Phases by X-ray Powder Diffraction /1 online resource (695 p.)
Studium reakcí molekulárních iontů v nízkoteplotním plazmatu
No full textXdzev pracc: Studinm rca,kci molokularmeh iontu v nizkoteplotnim plazmatu Autor: Peter Rubovic Katedra. (ustav): Katodra. fy/iky povrchu a plazmatu Vedonci bakalarske prace: RNDr. Radok Plasil. Ph.D. o-inail vedouciho: Radek.Plasil«i;n iff.cuni.cz Abstrakt: V predlo/enej ])i;ici skunuune reakcie molekularnych ionov v niz- koteplotnej plazme. Je popisany prineip a konslrukcia aparatury FALP (Flo- wing Afterglow with Langmuir Probe}, ])omocon ktorej skumame dohasinajucu plazmu pouzithn Langmnirovej (elektrostatickej) sondy. Zkonstrnovali snic ki- netieky model ehemickych reakeii a jcho ])ocitacovy model. Diskntnjeme vystup tohoto modelu - cn.sovy vyvoj koiicentracii j(xlnotlivyeh ionov a elektronov y>o- 7A\\7. prndovej trnbico. Zucastnili sine sa na i'i]jra,votreby merania pri te])lotiich tekuteho dnsiku. C'ielbm prace je urcit rychlost.ny koefi- eient rekoinbinacie ionu HCO' s elektromni a jeho zavi.slost' na koiicentracii reaktantu ILj a teplote. Z nameranych /avislosti usud/ujeme, ze .sa jedna o di- sociativnn rckombinacin. Klicova slova: FALP, rekombinacia. kinetika reakeii, pocitacovy model Title: Reactions of Molecular Ions in Low-Temperature Plasma Author: Peter Rnbovic Department: Department of Surface and Plasma Science Supervisor: RNDr. Radek PlasiL Ph.D. Supervisor's e-mail...Xdzev pracc: Studinm rca,kci molokularmeh iontu v nizkoteplotnim plazmatu Autor: Peter Rubovic Katedra. (ustav): Katodra. fy/iky povrchu a plazmatu Vedonci bakalarske prace: RNDr. Radok Plasil. Ph.D. o-inail vedouciho: Radek.Plasil«i;n iff.cuni.cz Abstrakt: V predlo/enej ])i;ici skunuune reakcie molekularnych ionov v niz- koteplotnej plazme. Je popisany prineip a konslrukcia aparatury FALP (Flo- wing Afterglow with Langmuir Probe}, ])omocon ktorej skumame dohasinajucu plazmu pouzithn Langmnirovej (elektrostatickej) sondy. Zkonstrnovali snic ki- netieky model ehemickych reakeii a jcho ])ocitacovy model. Diskntnjeme vystup tohoto modelu - cn.sovy vyvoj koiicentracii j(xlnotlivyeh ionov a elektronov y>o- 7A\\7. prndovej trnbico. Zucastnili sine sa na i'i]jra,votreby merania pri te])lotiich tekuteho dnsiku. C'ielbm prace je urcit rychlost.ny koefi- eient rekoinbinacie ionu HCO' s elektromni a jeho zavi.slost' na koiicentracii reaktantu ILj a teplote. Z nameranych /avislosti usud/ujeme, ze .sa jedna o di- sociativnn rckombinacin. Klicova slova: FALP, rekombinacia. kinetika reakeii, pocitacovy model Title: Reactions of Molecular Ions in Low-Temperature Plasma Author: Peter Rnbovic Department: Department of Surface and Plasma Science Supervisor: RNDr. Radek PlasiL Ph.D. Supervisor's e-mail...Department of Surface and Plasma ScienceKatedra fyziky povrchů a plazmatuFaculty of Mathematics and PhysicsMatematicko-fyzikální fakult
Making Law? Parliament v The Charity Commission
No full textCharities have long played a vital role in our society so much so that the law has recognised for centuries the benefit they bring to the public. But, says Professor Peter Luxton, in Making Law? Parliament v The Charity Commission, serious confusion has now arisen. Whereas the 2006 Charities Act is true to the historic position, the Charity Commission’s current guidance to charities is not fully in accordance with it.
It is not clear to many charities whether they are bound by the law, e.g., on public benefit as recognised by Parliament, or by the new interpretation given by the Charity Commission. The author considers how these serious problems have arisen and proposes a series of steps to resolve the difficulties. The relevant parts of the 2006 legislation should be replaced by simpler provisions and the structure and membership of the Charity Commission reformed to reduce party political influence on it. A charities' fighting fund could well be needed to enable charities to test the law and, if necessary, challenge the very dubious rulings of the Commission
Rozhovor Britských listů 173. S Peterem Hamesem o českém filmu [Britské listy interview 173. With Peter Hames on Czech cinema]
No full textAt the 2018 Karlovy Vary International Film Festival, Jan Culik interviews film historian Peter Hames, the author of a number of monographs and articles about Czechoslovak and Czech cinema. They speak about the importance of the 1960 Czech New Wave and its impact on British film makers. After a 90-second introduction in Czech, the fifteen minute interview is conducted in English, with Czech subtitles. The interview was broadcast on the Czech cable TV station Regionalnitelevize.cz from 13th July 2018
- …
