56,383 research outputs found
Let's Talk about the 'S' Word: what do care home staff want from training resources to support care home residents sexuality, intimacy and relationship needs
No full textThe sexuality, intimacy and relationship needs of older care home residents are often unnoticed, ignored, or dismissed (Simpson et al., 2015), but are important for maintaining health, wellbeing and personal identity (RCN 2018; Buttaro et al 2014). Care home staff find supporting residents sexuality and intimacy needs challenging and report an urgent need for training and guidance on this sensitive issue, as they are often faced with complex moral and legal dilemmas, when attempting to balance residents’ individual rights to sexual freedom with the need to safeguard vulnerable adults in their care (Simpson et al. 2016, 2017). We aimed to understand more about the specific training needs of care home staff in this area, to develop and evaluate a training resource to enable care home staff better support residents’ sexuality and intimacy needs. This paper presents the findings from: (i) a survey of UK care home managers about how they help residents who have sexual or intimacy needs, and any training they provide staff on this topic and (ii) four workshops with care home staff to explore their views on existing resources for supporting residents’ sexuality and intimacy needs, their previous experiences of training, and their everyday approaches to supporting residents sexuality, intimacy and relationship needs. The findings from the audit and workshop will be presented as well as suggestions for how this research might inform the development of an interactive training resource designed to help care home staff to better support their residents’ sexuality, intimacy and relationship needs
<i>P</i> values of the t test based on the results of the Shannon Wiener and Simpson indices.
No full textP values of the t test based on the results of the Shannon Wiener and Simpson indices.</p
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
A clinical and molecular investigation of two families with Simpson-Golabi-Behmel syndrome
No full textIncludes abstract (p. 30-32).
Includes bibliographical references
Kanter Revisited: Gender, Power and (In)visibility
No full textThis paper revisits Kanter's (1977) seminal work Men and Women of the Corporation, rereading her account of numerical advantage and disadvantage through a poststructuralist lens which exposes hidden dimensions of gendered power. This lens is captured in the ‘(In)visibility Vortex’ (Lewis and Simpson, 2010) which highlights struggles and tensions around the norm through processes of preservation and concealment within the norm as well as dynamics of revealing, exposure and disappearance as features of the margins. The study draws on developments in feminist theorizing, specially around visibility, invisibility and power, to facilitate this rereading. In so doing, the author demonstrate that while Kanter retreated from explanations based on the gendering of organizations or from recognition of gendered power, these dynamics can be identified in her text. The authors suggest that rereading classic texts can surface dimensions of organizations that have contemporary significance and can inform future research
Wave turbulence of a rotating array of quantized vortices in the T → 0 temperature limit
No full textThe dynamics of quantized vortices in the zero temperature limit is currently of great interest, particularly in the case of the Fermi superfluid He-B. Here we study wave turbulence, generated by the librating motion of a rotating cylindrical container filled with He-B, in the limit of vanishing viscous forces at temperatures . The polarization of the quantized vortices with respect to the axis of rotation is measured using non-invasive NMR techniques. We observe a decrease of the polarization when the librating motion is started, and a two-stage relaxation process when the modulation of the rotation velocity is stopped. The first relaxation process is associated with the dissipation of large-scale flow stored in inertial waves and the solid body rotation of the vortex array. From the decay of these energy reservoirs we determine the rate of energy dissipation of large-scale flow. The later second process is related to the relaxation of Kelvin waves on individual vortices. This process is monitored by the recovery of the polarization. The existence of a Kelvin wave cascade at the lowest temperatures is currently a central open question. We supply some evidence for the cascade
Simpson index analysis.
No full textMicrobial diversity analysis using Simpson index comparing those who were unsuccessful versus successful on the point subtest (A), the gaze subtest (B), at least one of the point and gaze subtests (C), as well as comparing the collection sites (D). A two-tailed t-test was performed between the successful and failed attempts. There was not a statistical difference between the groups. (TIF)</p
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
Trimuricea reticulata Thomson & Simpson 1909
No full textTrimuricea reticulata (Thomson & Simpson, 1909) (Figs. 21 c, 24–25) Echinomuricea reticulata Thomson & Simpson, 1909: 206. Trimuricea reticulata; Gordon 1926: 516, fig. 3; Grasshoff 1999: 48, fig. 80. Not T. aff. reticulata; Samimi-Namin & van Ofwegen 2009 a: 43. (= Trimuricea persica n. sp.). Material: Syntypes BMNH 1933.3.13.18Andamans, “Investigator", coll. Sir J.A. Thomson. The jar was painted as a type specimen and has a pencil written label at the bottom which has in addition to the above: L.M. Macfadyen 1922; BMNH 1933.5. 3.103, same data but labelled as a young colony; BMNH 1925.11. 24.44, same data, tiny fragment. Description (colony shape after Thomson & Simpson 1909). Grasshoff (1999: 48) mentioned he reexamined the holotype, but Thomson & Simpson never designated a holotype. In the British Museum three specimens labelled Echinomuricea reticulata are present; one specimen stored under BMNH 1933.5. 3.103, labelled as being a young colony, with the same data as the fragment examined by us (BMNH 1933.3.13.18; Figure 21 c); and BMNH 1925.11. 24.44, a tiny fragment. The main part of the material of this species is stored in the Indian Museum in Kolkata and unavailable for study. Thomson and Simpson described one specimen that is 20 cm high and 16 cm wide, and another 18 cm high and 11 cm wide. Both are branched in one plane and have a holdfast. In the larger colony the stem measures 2.5 mm at the base and tapers gradually to 1.5 mm near the tip. The diameter of the branches is almost uniform throughout. Abundant anastomoses are present. Polyps are closely set to each other, and situated all around the branches. The calyces are dome shaped, up to 0.5 mm in height and 1 mm in diameter. A young pearl oyster is attached to one of the branches of the smaller specimen and there is a cirripede gall overgrown by polyp-bearing coenenchyme on the larger specimen, which also bears a young crinoid. The points have triradiates (Fig. 24 a), along with curved, hockeystick or boot-shaped sclerites, or spindles (Fig. 24 b), 0.10–0.30 mm long. The upper ray of the triradiates and upper part of the spindles is slightly echinulate or smooth for up to 0.23 mm. The collaret spindles are 0.20–0.44 mm long (Fig. 24 c); the middle of the sclerites has very few tubercles as do the ends. A few tentacle scales are present, up to 0.10 mm long (Fig. 24 d). The calyces have thornscales, 0.10–0.38 mm long, with one long smooth or slightly echinulate thorn up to 0.23 mm long; the base of the thornscales has sparse, simple tubercles (Fig. 24 e, 25 a). The coenenchyme has narrow spindles, 0.15–0.65 mm long, with simple tubercles (Fig. 25 b); some of these spindles are triradiate or have a side branch. Colour. The preserved colony is light brown. All sclerites are colourless. There is no information about the colour of live colony and polyps. Remarks. Gordon’s description of the specimen she identified as Trimuricea reticulata does not agree with the description of T. reticulata by Thomson & Simpson (1909). Gordon’s specimen has smaller spindles in the coenenchyme (up to 0.5 mm long versus 0.65 mm for Thomson & Simpson’s material), and smaller polyp sclerites (up to 0.32 mm long versus 0.7 mm for Thomson & Simpson’s material). However, we found polyp sclerites of intermediate length (up to 0.44 mm long) and consider the measurements of the polyp sclerites by Thomson & Simpson incorrect and that Gordon’s measurements were correct. Noteworthy, in the original description of Echinomuricea reticulata is that Thomson & Simpson mentioned the presence of “irregular clubs”, which actually are thornscales upside down. It is not possible to tie the two colonies of the original description to the fragment we examined because Thomson & Simpson did not show any image and also the colony sizes they mentioned do not agree with what we re-examined. We can only assume we re-examined part of one of those two colonies. This species mostly resembles Trimuricea bicolor, T. inermis (Nutting, 1910), and T. omanensis as these species have sclerites with only simple tubercles. T. reticulata differs in having a much longer, more or less smooth, thorn on the thornscales (up to 0.23 mm long for T. reticulata compared to up to 0.15 mm long for the other three species), which also have a more complex base.Published as part of Samimi-Namin, Kaveh & Van Ofwegen, Leen P., 2016, A revision of Trimuricea Gordon, 1926 (Cnidaria: Octocorallia: Plexauridae) with the description of six new species, pp. 1-44 in Zootaxa 4105 (1) on page 32, DOI: 10.11646/zootaxa.4105.1.1, http://zenodo.org/record/27123
E-book : Industrial Transformation In The Developing World (author: Michael T. Rock & David P. Angel)
No full textArsip Kuliah Online 2010: E-book : Industrial Transformation In The Developing World (author: Michael T. Rock & David P. Angel
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