45,566 research outputs found
[Letter from J. H. Simpson, Texas Press Clipping Bureau to T. N. Carswell - October 2, 1942]
No full textA letter addressed to Mr. T. N. Carswell, Abilene, Texas, from Texas Press Clipping Bureau, by J. H. Simpson, Dallas, Texas, dated October 2, 1942. In reply to the request by Carswell for clippings Simpson advises that there are no past clippings on any of the subjects requested but that they would be glad to clip from future papers for as long as desired
Optimising the assessment of cerebral autoregulation from black box models
No full textCerebral autoregulation (CA) mechanisms maintain blood flow approximately stable despite changes in arterial blood pressure. Mathematical models that characterise this system have been used extensively in the quantitative assessment of function/impairment of CA. Using spontaneous fluctuations in arterial blood pressure (ABP) as input and cerebral blood flow velocity (CBFV) as output, the autoregulatory mechanism can be modelled using linear and non-linear approaches, from which indexes can be extracted to provide an overall assessment of CA. Previous studies have considered a single – or at most a couple of measures, making it difficult to compare the performance of different CA parameters. We compare the performance of established autoregulatory parameters and propose novel measures. The key objective is to identify which model and index can best distinguish between normal and impaired CA. To this end 26 recordings of ABP and CBFV from normocapnia and hypercapnia (which temporarily impairs CA) in 13 healthy adults were analysed. In the absence of a ‘gold’ standard for the study of dynamic CA, lower inter- and intra-subject variability of the parameters in relation to the difference between normo- and hypercapnia were considered as criteria for identifying improved measures of CA. Significantly improved performance compared to some conventional approaches was achieved, with the simplest method emerging as probably the most promising for future studies
A clinical and molecular investigation of two families with Simpson-Golabi-Behmel syndrome
No full textIncludes abstract (p. 30-32).
Includes bibliographical references
Glenn Myers Blain, R. Stewart Jones et Ray H. Simpson, Educational Psychology
No full textKriekemans A. Glenn Myers Blain, R. Stewart Jones et Ray H. Simpson, Educational Psychology. In: Revue Philosophique de Louvain. Troisième série, tome 57, n°54, 1959. p. 284
Glenn Myers Blain, R. Stewart Jones et Ray H. Simpson, Educational Psychology
No full textKriekemans A. Glenn Myers Blain, R. Stewart Jones et Ray H. Simpson, Educational Psychology. In: Revue Philosophique de Louvain. Troisième série, tome 57, n°54, 1959. p. 284
Haematotrephus jaenschi Johnston & Simpson 1940, n. comb.
No full textH. jaenschi (Johnston & Simpson, 1940) n. comb. Type host. Hoary-headed grebe, Poliocephalus poliocephalus (Jardine & Selby) (Podicipediformes: Podicipedidae)— Storer (2000). Type locality. Tailem Bend, lower Murray River, South Australia. Additional host. Australian grebe, Tachybaptus novaehollandiae (Stephens) (Syn. Podiceps novaehollandiae Stephens) (Podicipediformes: Podicipedidae)— Johnston & Simpson, (1940), Storer (2000). Remarks. This species was originally described as Cyclocoelum jaenschi Johnston & Simpson, 1940, but was transferred to Corpopyrum (= Haematotrephus) by Yamaguti (1958). This species has a pretesticular ovary that forms a triangle with the testes (Haematotrephinae), a postpharyngeal genital pore, the vitelline fields are not confluent posteriorly and the testes are diagonal to tandem, placing it in Haematotrephus. Although this species was described as lacking a ventral sucker as an adult, the cercarium is illustrated as having a rudimentary ventral sucker by Johnston & Simpson (1940).Published as part of Dronen, Norman O. & Blend, Charles K., 2015, Updated keys to the genera in the subfamilies of Cyclocoelidae Stossich, 1902, including a reconsideration of species assignments, species keys and the proposal of a new genus in Szidatitreminae Dronen, 2007, pp. 1-100 in Zootaxa 4053 (1) on page 54, DOI: 10.11646/zootaxa.4053.1.1, http://zenodo.org/record/23711
Molecular cloning and expression of cDNA encoding the rat UDP-N-Acetylglucosamine:-6-D Mannoside ?-1,2-N-Acetylglucosaminyltransferase II
No full textUDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside beta-1,2-N-acetylglucosaminyltransferase II (EC 2.4.1.143) (GnT II) is a Golgi resident enzyme that catalyzes an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of the enzyme purified from rat liver revealed a polypeptide of 42 kDa. Amino acid sequences were obtained from the N terminus and a tryptic peptide. Overlapping cDNA clones coding for the full-length rat GnT II were obtained. The complete nucleotide sequence revealed a 1326-base pair open reading frame that codes for a polypeptide of 442 amino acids, including a presumptive N-terminal membrane-anchoring domain. The region of cDNA coding for the C-terminal 389 amino acids of rat GnT II was linked in frame to a cDNA segment encoding the cleavable signal sequence of the human interleukin-2 receptor and transiently expressed in COS-7 cells. A 77-fold enhancement of GnT II activity over a control carrying the GnT II cDNA out-of-frame was detected in the culture medium at 72 h after transfection. 1H-NMR spectroscopy confirmed that the oligosaccharide synthesized in vitro by the recombinant enzyme was the product of GnT II activity. These data verify the identity of the cloned GnT II cDNA and demonstrate that the C-terminal region of the protein includes the catalytic domai
Improved estimates of autoregulation from spontaneous variations in blood flow and pressure
No full textRobert Bartell (H.) Jr, Simpson (E.T.) - Pensions Funds of Multiemployer Industrial Groups, Unions and Nonprofit Organizations.
No full textSellier François. Robert Bartell (H.) Jr, Simpson (E.T.) - Pensions Funds of Multiemployer Industrial Groups, Unions and Nonprofit Organizations.. In: Revue économique, volume 21, n°3, 1970. pp. 496-497
Estimation of interdomain flexibility of N-terminus of factor H using residual dipolar couplings
No full textCharacterization of segmental flexibility is needed to understand the biological mechanisms of the very large category of functionally diverse proteins, exemplified by the regulators of complement activation, that consist of numerous compact modules or domains linked by short, potentially flexible, sequences of amino acid residues. The use of NMR-derived residual dipolar couplings (RDCs), in magnetically aligned media, to evaluate interdomain motion is established but only for two-domain proteins. We focused on the three N-terminal domains (called CCPs or SCRs) of the important complement regulator, human factor H (i.e., FH1-3). These domains cooperate to facilitate cleavage of the key complement activation-specific protein fragment, C3b, forming iC3b that no longer participates in the complement cascade. We refined a three-dimensional solution structure of recombinant FH1-3 based on nuclear Overhauser effects and RDCs. We then employed a rudimentary series of RDC data sets, collected in media containing magnetically aligned bicelles (disklike particles formed from phospholipids) under three different conditions, to estimate interdomain motions. This circumvents a requirement of previous approaches for technically difficult collection of five independent RDC data sets. More than 80% of conformers of this predominantly extended three-domain molecule exhibit flexions of <40°. Such segmental flexibility (together with the local dynamics of the hypervariable loop within domain 3) could facilitate recognition of C3b via initial anchoring and eventual reorganization of modules to the conformation captured in the previously solved crystal structure of a C3b:FH1-4 complex.</p
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