1,552 research outputs found
Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome
No full textAbstract not availableKai-Leng Tan, King-Hwa Ling, Chelsee A. Hewitt, Pike-See Cheah, Ken Simpson, Lavinia Gordon, Melanie A. Pritchard, Gordon K. Smyth, Tim Thomas, Hamish S. Scot
Dataset for the paper "Climate model bias indicates higher projected future temperature extremes"
No full text<div>
<div>This repository holds data and scripts used to produce the paper entitled:</div>
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<div>"Climate model bias indicates higher projected future temperature extremes"</div>
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<div>by Lei Duan, Lyssa M. Freese, Govindasamy Bala, and Ken Caldeira.</div>
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<div>The paper is currently submitted for peer review.</div>
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<div>Any questions regarding the data and paper could be sent to the corresponding author: Lei Duan ([email protected])</div>
</div>
Elkhorn Drive Scenic Byway management plan, Wallowa-Whitman National Forest : visitor services and management plan
No full textTitle from PDF cover (viewed on September 11, 2019).Includes addendum to Elkhorn Drive National Scenic Byway Plan, prepared by Connie M. Pound and Ken Koon.This archived document is maintained by the State Library of Oregon. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references.Mode of access: Internet from the State Library of Oregon U.S. Government Publications Collection.Text in English
Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients
No full textBackground: Intra-rectal artesunate has been developed as a potentially life-saving treatment of severe
malaria in rural village settings where administration of parenteral antimalarial drugs is not
possible. We studied the population pharmacokinetics of intra-rectal artesunate and the
relationship with parasitological responses in patients with moderately severe falciparum
malaria.
Methods and Findings: Adults and children in Africa and Southeast Asia with moderately severe malaria were recruited
in two Phase II studies (12 adults from Southeast Asia and 11 children from Africa) with intensive sampling protocols, and three Phase III studies (44 children from Southeast Asia, and 86 children and 26 adults from Africa) with sparse sampling. All patients received 10 mg/kg artesunate as a single intra-rectal dose of suppositories. Venous blood samples were taken during a period of 24h
following dosing. Plasma artesunate and dihydroartemisinin (DHA, the main biologically active metabolite) concentrations were measured by high-performance liquid chromatography with electrochemical detection. The pharmacokinetic properties of DHA were determined using
nonlinear mixed-effects modelling. Artesunate is rapidly hydrolysed in vivo to DHA, and this contributes the majority of antimalarial activity. For DHA, a one-compartment model assuming complete conversion from artesunate and first-order appearance and elimination kinetics gave the best fit to the data. The mean population estimate of apparent clearance (CL/F) was 2.64 (l/kg/
h) with 66% inter-individual variability. The apparent volume of distribution (V/F) was 2.75 (l/kg) with 96% inter-individual variability. The estimated DHA population mean elimination half-life was 43 min. Gender was associated with increased mean CL/F by 1.14 (95% CI: 0.36–1.92) (l/kg/h) for a male compared with a female, and weight was positively associated with V/F. Larger V/Fs were observed for the patients requiring early rescue treatment compared with the remainder, independent of any confounders. No associations between the parasitological responses and the
posterior individual estimates of V/F, CL/F, and AUC0–6h were observed.
Conclusions: The pharmacokinetic properties of DHA were affected only by gender and body weight. Patients with the lowest area under the DHA concentration curve did not have slower parasite clearance, suggesting that rectal artesunate is well absorbed in most patients with moderately
severe malaria. However, a number of modelling assumptions were required due to the large intra- and inter-individual variability of the DHA concentrations
A review of "Spiritual Architecture and Paradise Regained : Milton���s Literary Ecclesiology" By Ken Simpson
No full textThe Impact of Service-Learning on Undergraduate Kinesiology Majors' Self-Efficacy Toward Working With Individuals With Disabilities
No full textIntro: Undergraduate kinesiology students can benefit by improved self-efficacy resulting from service-learning experiences which are necessary to prepare educators to teach individuals with disabilities (IWD) with real-life experiences. However, only a few service-learning courses in the field of kinesiology are offered, which leads to the current issues of lack of varied experience, lack of exposure to disabilities, limited guidance in learning to teach IWD, and limited funding sources and quality assurance (Narasaki-Jara et al., 2020; Santiago et al., 2016) Purpose: The purpose of this study was to investigate undergraduate kinesiology students' self-efficacy toward working with IWD over an 8-week in-person service-learning program. Method: This quantitative study included 100 undergraduate students from one institution in southern California who completed a survey that collected responses to the Teaching Students with Disabilities Efficacy Scale (Solomon & Scott, 2013) that measure self-efficacy toward working with IWD. The sample was 36 male and 64 female undergraduate kinesiology students and averaged 22.26 years. Repeated measures ANOVA was utilized to analyze the data, with the significance level set at p < 0.05. Results: There were no significant group x time differences in the intervention group and the control group. However, there is a trend of 5.2% increase in self-efficacy score in the intervention group (pre: m = 6.73 to post: m = 7.08) while there is a 2% increase in the control group (pre: m = 7.05 to post: m = 7.19). There was no significant difference between the genders in this study. However, females exhibited a 3% increase in self-efficacy scores (from m = 6.88 to m = 7.33), while males showed a 3% decrease (from m = 7.00 to m = 6.83). Conclusion: This study has provided valuable insights into the impact of service-learning programs. The study has contributed to the existing body of knowledge on the relationship between service-learning and self-efficacy toward working IWD. The findings have practical implications for the importance of service-learning programs that provide kinesiology professionals with a real-life setting practicum during the undergraduate academic perio
Performance of a seismicity model based on three parameters for earthquakes (M ≥ 5.0) in Kanto, central Japan
No full textWe constructed a model of earthquakes (M ≥ 5.0) in Kanto, central Japan, based on three parameters: the a and
b values of the Gutenberg-Richter relation, and the ν- parameter of changes in mean event size. In our method,
two empirical probability densities for each parameter, those associated with target events (conditional density
distributions) and those not associated with them (background density distributions), are defined and assumed to
have a normal distribution. Therefore, three parameters are transformed by appropriate relations so that new parameters
are normally distributed. The retrospective analysis in the learning period and the prospective test of
testing period demonstrated that the proposed model performs better by about 0.1 units in terms of the information
gain per event than the value summed up with those of the three parameters. The results are confirmed by
a simulation with randomly selected model parameters.JCR Journalope
Regularized Capon Beamformer Using ℓ1-Norm Applied to Photoacoustic Imaging
No full textDelay-and-Sum (DAS), as a non-adaptive beamforming method, is one of the most common algorithms used in Photoacoustic imaging due to its simple implementation. The results obtained from this algorithm suffer from low resolution and high sidelobes. The adaptive Minimum variance (MV) method improves the image quality compared to DAS in terms of resolution and contrast. In this paper, it is proposed to add a ℓ1-norm regularization term to the conventional MV minimization problem and create a new sparse beamforming method, named Modified-Sparse-Mv (ms-Mv)algorithm. In fact, the sparsity of the output is forced to the beampattern by adding this new sparse added term, which results in more noise reduction and sidelobe suppression compared to MV. The minimization problem is convex, and therefore, it can be solved using an iterative algorithm. The results show that the proposed MS-MV method improves the signal-to-noise-ratio for about 5.36 dB and 6.44 dB compared to DAS and MV, respectively, for the designed wire phantom.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.ImPhys/Acoustical Wavefield Imagin
Perceptions, 1994
No full textVolume 13, 53 pages. Editor: Paul Hodo.
Contributors, Prose and Poetry: Marleen Springston, Joni Susanne Payne, Bridget Hogan, James Groome, Angella Kamminga, Alisha Goodman, Ty Burgess, Ron Reach, Brian Ross, Candy Sains, and Paul Hodo.
Contributors, Art: Michelle Hardigree, Ken Halverson, Diana M. Dyer, Sean Berry, Justin Mayhew, David Vanvalkenburg, Laura Simpson, and Debbi Martin.https://digitalcommons.northgeorgia.edu/perceptions/1012/thumbnail.jp
Qubit Device Integration Using Advanced Semiconductor Manufacturing Process Technology
No full text Quantum computing's value proposition of an exponential speedup in computing power for certain applications has propelled a vast array of research across the globe. While several different physical implementations of device level qubits are being investigated, semiconductor spin qubits have many similarities to scaled transistors. In this article, we discuss the device/integration of full 300mm based spin qubit devices. This includes the development of (i) a 28 Si epitaxial module ecosystem for growing isotopically pure substrates with among the best Hall mobility at these oxide thicknesses, (ii) a custom 300mm qubit testchip and integration/device line, and (iii) a novel dual nested gate integration process for creating quantum dots. Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.QCD/Vandersypen LabQCD/Veldhorst LabTU Delft ServicesQCD/Scappucci LabQN/Vandersypen La
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