260 research outputs found
Investigating the relationship between the actin-spectrin periodic scaffold and clathrin-mediated endocytosis at the axon initial segment
No full textNeuronale cellen zijn sterk afhankelijk van clathrine-gemedieerde endocytose. Dit proces wordt voornamelijk bestudeerd in somatodendritische compartimenten en in presynapsen. Dit mechanisme is echter slecht bestudeerd langs de axonschacht. Ons laboratorium heeft onlangs aangetoond dat het oppervlak van het proximale axon bezaaid is met met clathrine beklede putjes, ingekapseld in cirkelvormige openingen van een submembraneuze structuur. Deze submembraneuze structuur, de membrane associated periodic scaffold (MPS), bestaat uit actine ringen die met elkaar zijn verbonden door een spectrine. Endocytose langs het axon is niettemin een zeldzame gebeurtenis, aangezien de clathrine beklede putjes stabiel vastzitten op het membraan. Endocytose kan worden veroorzaakt door stimuli zoals verhoogde neuronale activiteit geïnduceerd door NMDA. In dit onderzoeksproject hebben we super-resolutiemicroscopietechnieken gebruikt in combinatie met opname assays en MPS-modulerende stoffen om het onderliggende mechanisme te onderzoeken dat clathrine-gemedieerde endocytose aanstuurt langs het proximale axon van gekweekte embryonale hippocampale neuronen van ratten. Resultaten hebben een gedeeltelijke verstoring van de spectrine-scaffold en verhoogde clathrine-gemedieerde endocytose aangetoond na door NMDA geïnduceerde langdurige depressie. Bovendien hebben we actine polymerisatie rond clathrine putjes waargenomen na NMDA-behandeling, en het voorkomen van deze polymerisatie met latrunculine A remde de toename van endocytose
Investigating the relationship between the actin-spectrin periodic scaffold and clathrin-mediated endocytosis at the axon initial segment
No full textNeuronale cellen zijn sterk afhankelijk van clathrine-gemedieerde endocytose. Dit proces wordt voornamelijk bestudeerd in somatodendritische compartimenten en in presynapsen. Dit mechanisme is echter slecht bestudeerd langs de axonschacht. Ons laboratorium heeft onlangs aangetoond dat het oppervlak van het proximale axon bezaaid is met met clathrine beklede putjes, ingekapseld in cirkelvormige openingen van een submembraneuze structuur. Deze submembraneuze structuur, de membrane associated periodic scaffold (MPS), bestaat uit actine ringen die met elkaar zijn verbonden door een spectrine. Endocytose langs het axon is niettemin een zeldzame gebeurtenis, aangezien de clathrine beklede putjes stabiel vastzitten op het membraan. Endocytose kan worden veroorzaakt door stimuli zoals verhoogde neuronale activiteit geïnduceerd door NMDA. In dit onderzoeksproject hebben we super-resolutiemicroscopietechnieken gebruikt in combinatie met opname assays en MPS-modulerende stoffen om het onderliggende mechanisme te onderzoeken dat clathrine-gemedieerde endocytose aanstuurt langs het proximale axon van gekweekte embryonale hippocampale neuronen van ratten. Resultaten hebben een gedeeltelijke verstoring van de spectrine-scaffold en verhoogde clathrine-gemedieerde endocytose aangetoond na door NMDA geïnduceerde langdurige depressie. Bovendien hebben we actine polymerisatie rond clathrine putjes waargenomen na NMDA-behandeling, en het voorkomen van deze polymerisatie met latrunculine A remde de toename van endocytose
Correction to: Should Doctors Offer Biomarker Testing to Those Afraid to Develop Alzheimer’s Dementia?: Applying the Method of Reflective Equilibrium for a Clinical Dilemma (Journal of Bioethical Inquiry, (2022), 19, 2, (287-297), 10.1007/s11673-022-10167-x)
No full textIn this article the author name Eline M. Bunnik was incorrectly written as Eline M. Bunnick. The original article has been corrected
On ableism and anthropocentrism: A canine perspective on the workplace inclusion of disabled people
No full textDespite growing attention for how disabled people become Othered in organizational settings and similar scholarly interest in the treatment of non-humans at work, no analysis so far has focused on the potential double marginalization that takes place when disabled people go to work with their service animal. In filling this void, this study draws attention to the embodied entanglement of 'humanimal' in a number of organizations where animals are unexpected. The study argues that the spatial, discursive and affective treatment of service dogs operates as a proxy for the in/exclusion of employees with mobility and visual impairments. This way, processes of ableism become masked as subtle and indirect performances towards non-human Others. Contributions are made towards several literatures by introducing the idea of a 'proxy' to help understand the different modes of peripheral inclusion of disabled employees via their legally accepted service animals, by bringing in the role of affect in workplace disablement, and finally by taking animal labour more seriously.The author received no financial support for the research, authorship and/or publication of this article.
The illustrations used in this article are the intellectual property of Benoît Raucent (UCLouvain). I thank Benoît and I thank the participants in this study for their valuable contributions
Turning disability into a business: Disabled entrepreneurs' anomalous bodily capital
No full textIn a time and place where being impaired is equated to being of lesser economic value, some disabled people take matters into their own hands by creating their own job and converting their bodily difference into bodily capital. This paper uses a Bourdieuan lens to discover what sets apart disabled entrepreneurs who build their business around disability and those who do not. Building on the experiences of 40 entrepreneurs, we outline the existence of certain bodily and mental schemata that lead to a body habituated to run a business centred around one's impairment and experience of living as a disabled person in an ableist world. We specify such 'anomalous' bodily capital and discuss the constraints to its conversion related to the social environment and impairment effects. This study speaks back to the literature on disability in organizational contexts by extending the 'value in disability' debate whilst remaining cognizant of the danger of 'supercrip' stereotyping and disability ghettoization. In addition, the complex structure/agency interplay inherent to the practice of leveraging anomalous bodily capital offers a contribution to entrepreneurship research that tends to adhere to a simplistic view of the body.The author(s) received no financial support for the research, authorship, and/or publication of this article
Editorial: The impact of exposure to environmental chemicals, pharmaceuticals and particles via human breast milk: a focus on health effects and underlying mechanisms
No full textThe author(s) declare that financial support was received for the research and/or publication of this article. Charlotte Cosemans was financially supported by the Research Foundation Flanders (FWO; 1249025N)
Application of the ECOV method for assessing the load-bearing capacity of existing structures
No full textThis publication contains the proceedings of the 2nd International Conference on Circularity in the Built Environment (CiBEn2025), held in Tampere, Finland, in September 16–18, 2025. The book includes both abstracts and papers of the contributions presented in the conference, as the authors were given the freedom to choose which type they submitted. All the contributions, except the keynotes, have been peer-reviewed in a double-blind setting by two independent reviewers. In this book, the contributions are listed under each theme in the alphabetical order of the title, so no order of importance is implied. The proceedings have been put together from ‘camera-ready’ files delivered by the authors. Due to this, some discrepancies may appear in the graphical appearance and/or how the content is structured. How to cite this publication as a whole: Huuhka, S. (Ed.). 2025. Circularity in the Built Environment: Proceedings of the 2025 conference held in Tampere, Finland, September 16–18 2025. Tampere: Tampere University. https://doi.org/10.5281/zenodo.17092525 How to cite a contribution in this publication: Author, A. (2025). Title of the contribution. In: Huuhka, S. (Ed.). Circularity in the Built Environment: Proceedings of the 2025 conference held in Tampere, Finland, September 16–18 2025. Tampere: Tampere University. https://doi.org/10.5281/zenodo.17092525Reusing precast concrete for a circular economy. European Commission. award Number:958200. 10.13039/50110000078
Proof of concept of social impact assessment of sustainable commuting measures for employee profiles
No full textCivil Engineering | Transport and Plannin
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