1,721,695 research outputs found

    Membrane estrogen receptor and follicle-stimulating hormone receptor

    No full text
    Follicle-stimulating hormone (FSH) and estrogens are fundamental to support reproductive functions. Beside the well-known FSH membrane receptor (FSHR), a G protein-coupled estrogen receptor (GPER) has been found, over the last two decades, in several tissues. It may trigger rapid, non-genomic responses of estradiol, activating proliferative and survival stimuli. The two receptors were co-characterized in the ovary, where they modulate different intracellular signaling cascades, according to the expression level and developmental stage of ovarian follicles. Moreover, they may physically interact to form heteromeric assemblies, suggestive of a new mode of action to regulate FSH-specific signals, and likely determining the follicular fate between atresia and dominance. The knowledge of FSH and estrogen membrane receptors provides a new, deeper level of comprehension of human reproduction

    Directorate ties: a bibliometric analysis

    No full text
    Purpose: Over the last 100 years, research on interlocking directorates has proliferated. The purpose of this paper is to realize a bibliometric analysis of articles on interlocking directorates to identify the evolutionary patterns that characterize the studies on board interlocks. Design/methodology/approach: A bibliometric analysis of articles on interlocking directorates published since 1914 was realized to evidence how research has evolved over time. Papers were classified according to the research topic, the type of article and the use of different theories to explain board interlocks’ causes and effects. Findings: The authors identified four different periods that characterize board interlocks studies: the emerging debate, the earliest modern era, the modern era and the post-modern era. Originality/value: This bibliometric analysis assesses the extant literature by highlighting emerging trends and identifying several avenues for future research

    Endocrine Laboratory Diagnosis

    No full text
    The measurements of serum gonadotropins, testosterone, SHBG, and calculated free testosterone have a central role in the endocrine diagnostics of male hypogonadism and infertility. Additional hormone determinations include the newest specific markers of Sertoli (inhibin B, anti-mullerian hormone) and Leydig (insulin-like factor 3) cell function. Dynamic tests (GnRH and hCG stimulation tests) are useful in the assessment of pituitary and testis reserve capacity. In selected cases, molecular biology techniques may be helpful in the endocrine workup
    corecore