70 research outputs found
The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count
No full textAbstract not availableSimone L. Broer, Ben Willem J. Mol, Dave Hendriks, and Frank J.M. Broekman
The role of anti-Mullerian hormone assessment in assisted reproductive technology outcome
No full textAbstract not availableSimone L. Broer, BenWillem Mol, Madeleine Dólleman, Bart C. Fauser and Frank J.M. Broekman
Applications of the one-fluid and the two-fluid model in magnetohydrodynamics
No full textMechanical, Maritime and Materials Engineerin
Economics of spatial coexistence of genetically modified and conventional crops: Oilseed rape in Central France
No full textEurope is currently struggling to implement coherent coexistence regulations on genetically modified (GM) and non-GM crops in all EU Member States. We conduct simulations with the software ArcView® on a GIS dataset of a hypothetical case of GM herbicide tolerant oilseed rape cultivation in Central France. Our findings show that rigid coexistence rules, such as large distance requirements, may impose a severe burden on GM crop production in Europe. These rules are not proportional to the farmers’ basic incentives for coexistence and hence not consistent with the objectives of the European Commission. More alarming, we show that in densely planted areas a domino-effect may occur. This effect raises coexistence costs and even adds to the non-proportionality of rigid coexistence regulations. Instead, we show that flexible measures would be preferable since they are proportional to the incentives for coexistence and, hence, less counterproductive for European agriculture.regulation, GIS modelling, domino-effect, Crop Production/Industries,
Financing Retirement in the European Union
No full textThis paper explores how EU countries can address various challenges (including the aging of the population) affecting their systems of old-age income support. It presents two scenarios illustrating the most important uncertainties surrounding the major developments that affect the pension systems of the EU. To diversify these risks, EU governments should act on several fronts. In addition to the formation of human capital (especially that of children), employment (especially that of older workers) should be boosted. This calls for social insurance reform with more emphasis on individual saving schemes. Pension schemes should be more explicit about how they share demographic and other risks. Countries that currently rely heavily on public pay-as-you-go (PAYG) schemes should stimulate private pensions by gradually reducing PAYG benefits collected by high-income earners, by issuing new financial instruments, and by conducting intergenerational risk sharing through the tax system.
The relation between variation in size of the primordial follicle pool and age at natural menopause
No full textContext: Tumors producing insulin-like growth factor 2 (IGF-2oma) are a major cause of spontaneous hypoglycemia. The treatment mainstay is surgical resection. Many case reports note resolution of hypoglycemia after IGF-2oma resection; however, outcomes are variable according to tumor type. We report a case of resolving hypoglycemia, observed on continuous glucose monitoring (CGM), after resection of an IGF-2-producing solitary fibrous tumor, of pleura and review the current literature. Case Report: A 69-year-old woman presented with impaired consciousness because of hypoglycemia. An IGF-2oma was diagnosed as the cause for hypoglycemia because of decreased serum insulin and IGF-1, presence of a pleural tumor, and a high-molecular-weight form of serum IGF-2 detected by western immunoblot. Surgical resection was performed; pathological examination demonstrated a solitary fibrous tumor with low-grade malignancy. CGM showed reversal of hypoglycemia after tumor resection. Approximately 2 years after resection, the patient has no signs of tumor recurrence or hypoglycemia. Conclusions: An IGF-2-producing solitary fibrous tumor of pleura in this case caused hypoglycemia. From a search of the literature of 2004–2014, 32 cases of IGF-2oma with hypoglycemia that underwent radical surgery were identified; in 19 (59%) patients, hypoglycemia was reversed and there was no subsequent recurrence. The remaining 13 (41%) experienced tumor recurrence or metastasis and recurrence of hypoglycemia average 43 months after initial tumor resection. The tumor of the present case was a low-grade malignancy. Regular follow-up with biomarker-monitoring of glucose metabolism and assessment of hypoglycemic symptomatology, in conjunction with imaging tests, is important for detecting possible tumor recurrence and metastasis.Peer reviewe
A self-conscious Kurt Vonnegut: an analysis of Cat's Cradle, Slaughterhouse-Five and Breakfast of Champions
No full textThe works of Kurt Vonnegut stand as seminal in the American literary canon. Looking at three of his most influential novels, namely Cat's Cradle, Slaughterhouse-Five and Breakfast of Champions, this study aims to better understand the mechanisms which inform his fiction. Working chronologically through the novels, the study examines historical context, narrative technique, theoretical underpinnings and the social critique of each novel. Guided by an idea of the postmodern novel the study examines how these elements interact, concluding that by way of what may be considered "simple" yet self-conscious metafiction and prose as well as variations in narrative technique, Vonnegut is able to more accurately convey his opinions on the American situation as well as demonstrate his stance on the role of fiction and the writer in contemporary society. The study also considers closely the role of the reader and the author/reader/text relationship
Does AMH relate to timing of menopause? Results of an individual patient data meta-analysis
No full textContext: Anti-Müllerian hormone (AMH)–based age at menopause predictions remain cumbersome due to predictive inaccuracy. Objective: To perform an individual patient data meta-analysis, regarding AMH-based menopause prediction. Design: A systematic literature search was performed using PubMed, Embase, and Cochrane databases. Prospective cohort studies regarding menopause prediction using serum AMH levels were selected by consensus discussion. Individual cases were included if experiencing a regular cycle at baseline. Exclusion criteria were hormone use and gynecological surgery. Results: This meta-analysis included 2596 women, and 1077 experienced menopause. A multivariable Cox regression analysis assessed time to menopause using age and AMH. AMH predicted time to menopause; however, added value on top of age was poor [age alone: C-statistic, 84%; age + AMH: hazard ratio (HR), 0.66; 95% CI, 0.61 to 0.71; C-statistic, 86%). Moreover, the capacity of AMH to predict early (≤45 years) and late menopause (≥55 years) was assessed. An added effect of AMH was demonstrated for early menopause (age alone: C-statistic 52%; age + AMH: HR, 0.33; 95%, CI 0.24 to 0.45; C-statistic, 80%). A Weibull regression model calculating individual age at menopause revealed that predictive inaccuracy remained present and increased with decreasing age at menopause. Lastly, a check of non-proportionality of the predictive effect of AMH demonstrated a reduced predictive effect with increasing age. Conclusion: AMH was a significant predictor of time to menopause and especially of time to early menopause. However, individual predictions of age at menopause demonstrated a limited precision, particularly when concerning early age at menopause, making clinical application troublesome.Martine Depmann, Marinus J.C. Eijkemans, Simone L. Broer, Fahimeh R. Tehrani, Masoud Solaymani-Dodaran, Fereidoun Azizi, Cornelis B. Lambalk, John F. Randolph, Jr., Sioban D. Harlow, Ellen W. Freeman, Mary D. Sammel, W.M. Monique Verschuren, Yvonne T. van der Schouw, Ben W. Mol and Frank J.M. Broekman
Generalized -signatures of the rings of invariants of finite group schemes
No full textLet be a perfect field of prime characteristic , a finite group
scheme over , and a finite-dimensional -module. Let
be the symmetric algebra with the standard grading.
Let be a -graded -finite -free -module, and be its
-reflexive graded -submodule.
Assume that the action of on is small in the sense that there exists
some -stable Zariski closed subset of of codimension two or more
such that the action of on is free. Generalizing the result
of P. Symonds and the first author, we describe the Frobenius limit
of the -module . In particular, we
determine the generalized -signature for each indecomposable
gradable reflexive -module . In particular, we prove the fact that the
-signature equals if is linearly
reductive (already proved by Watanabe--Yoshida,
Carvajal-Rojas--Schwede--Tucker, and Carvajal-Rojas) and otherwise (some
important cases has already been proved by Broer, Yasuda,
Liedtke--Martin--Matsumoto).Comment: 19 pages.In the 2nd version of this paper, the statements of Theorem
3.16 in the introduction and the same theorem in the text were slightly
different. We modified the statement in the introduction so that it is
exactly the same as that in the tex
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