170 research outputs found
Replication Data for Zonulin levels for "Bacterial DNAemia is associated with serum zonulin levels in older subjects"
No full textData including: list of Subjects, Sex, Age, BMI, Bacterial load (16S rRNA g.c./μl) and Zonulin level (ng/ml), for sample sets 1 and 2
Replication Data for Blood Microbiomics for "Bacterial DNAemia is associated with serum zonulin levels in older subjects"
No full text16S rRNA gene profiling data of DNA extracted from 50 blood samples collected from heatlhy elederly people.\r\nBacterial populations contained in the samples were determined using next generation high throughput sequencing of variable regions (V3-V4) of the 16S rRNA bacterial gene through MiSeq Illumina technology
Replication Data for 16S rRNA gene profiling of blood samples and controls for "Bacterial DNAemia is associated with serum zonulin levels in older subjects"
No full textFASTQ data (R1 and R2) generated by metataxonomics of blood samples and controls. In brief, DNA extracted from whole blood and controls were used for 16S rRNA gene profiling using MiSeq Illumina technology (2 x 300 paired-end MiSeq kit V3, set to encompass 467-bp amplicon)
Replication Data for 16S rRNA gene sequencing for: "Modulation of Pulmonary Microbiota by Antibiotic or Probiotic Aerosol Therapy: A Strategy to Promote Immunosurveillance against Lung Metastases"
No full textThis dataset contains the following files:\r\n\r\n(1) 20 files \"fastq.gz\": files containing the raw sequencing data (FASTQ files) of the 16S rRNA gene profiling carried out on DNA extracted from BAL of antibiotic-treated (files from A1 to A5) and untreated mice (files from C1 to C5). The 16S rRNA gene was amplified using primers EUBF 5’-TCCTACGGGAGGCAGCAGT-3’ and EUBR 5’ -GGACTACCAGGGTATCTAATCCTGTT-3’ (DOI: 10.1099/00221287-148-1-257), which target the V3-V4 hypervariable regions, and sequenced using MiSeq Illumina® technology (2 x 300 paired-end MiSeq kit V3, set to encompass 467-bp amplicon) as previously described (DOI: 10.1371/journal.pone.0142334; DOI: 10.1111/trf.13477).\r\n\r\n(2) File named \"16S rRNA gene sequences.docx\": Word file containing the nucleotide sequences of part of the 16S rRNA gene amplified from the DNA of the bacterial strains isolated from the bronchoalveolar lavage fluid (BAL) of antibiotic-treated and untreated mice. Before each sequence, the first output of BLASTN search performed with default parameters against the \"16 ribosomal RNA sequences (Bacteria and Archaea)\" database.\r\n\r\nFor any additional need to this datasets, contact: [email protected] and [email protected]
Erratum: Increased Intestinal Permeability in Older Subjects Impacts the Beneficial Effects of Dietary Polyphenols by Modulating Their Bioavailability (J. Agric. Food Chem. (2020) 68:44 (12476-12484) DOI: 10.1021/acs.jafc.0c04976)
No full textIn the list of authors, the correct order is as follows: Rau ́l Gonzal ́ ez-Domin ́ guez*, Nicole Hidalgo-Liberona, Esteban Vegas, Patrizia Riso, Cristian Del Bo’, Stefano Bernardi, Gregorio Peron, Simone Guglielmetti, Giorgio Gargari, Paul Antony Kroon, Antonio Cherubini, and Cristina Andre ́s-Lacueva*
Safety considerations in the use of nonviable microbial cells as health-promoting agents in food and dietary supplements
No full textThe immunomodulatory properties of probiotic microorganisms beyond their viability (ghost probiotics: proposal of paraprobiotic concept)
No full textThe probiotic approach represents a potentially effective and mild alternative strategy for the prevention and treatment of either inflammatory or allergic diseases. Several studies have shown that different bacterial strains can exert their probiotic abilities by influencing the host's immune system, thereby modulating immune responses. However, the emerging concern regarding safety problems arising from the extensive use of live microbial cells is enhancing the interest in non-viable microorganisms or microbial cell extracts, as they could eliminate shelf-life problems and reduce the risks of microbial translocation and infection. The purpose of this review is to provide an overview of the scientific literature concerning studies in which dead microbial cells or crude microbial cell fractions have been used as health-promoting agents. Particular attention will be given to the modulation of host immune responses. Possible mechanisms determining the effect on the immune system will also be discussed. Finally, in the light of the FAO/WHO definition of probiotics, indicating that the word 'probiotic' should be restricted to products that contain live microorganisms, and considering the scientific evidence indicating that inactivated microbes can positively affect human health, we propose the new term 'paraprobiotic' to indicate the use of inactivated microbial cells or cell fractions to confer a health benefit to the consumer
Health-promoting properties of Lactobacillus helveticus
No full textLactobacillus helveticus is an important industrial thermophilic starter that is predominantly employed in the fermentation of milk for the manufacture of several cheeses. In addition to its technological importance, a growing body of scientific evidence shows that strains belonging to the L. helveticus species have health-promoting properties. In this review, we synthesize the results of numerous primary literature papers concerning the ability of L. helveticus strains to positively influence human health. Several in vitro studies showed that L. helveticus possesses many common probiotic properties, such as the ability to survive gastrointestinal transit, adhere to epithelial cells and antagonize pathogens. In vivo studies in murine models showed that L. helveticus could prevent gastrointestinal infections, enhance protection against pathogens, modulate host immune responses, and affect the composition of the intestinal microbiota. Interventional studies and clinical trials have also demonstrated a number of health-promoting properties of L. helveticus. Finally, several studies suggested that specific enzymatic activities of L. helveticus could indirectly benefit the human host by enhancing the bioavailability of nutrients, removing allergens and other undesired molecules from food, and producing bioactive peptides through the digestion of food proteins. In conclusion, this review demonstrates that in light of the scientific literature presented, L. helveticus can be included among the bacterial species that are generally considered to be probiotic
Eye tracking communication devices in amyotrophic lateral sclerosis: Impact on disability and quality of life
No full textPeople with amyotrophic lateral sclerosis (PwALS) show progressive loss of voluntary muscle strength. In advanced disease, motor and phonatory impairments seriously hinder the patient's interpersonal communication. High-tech devices such as eye tracking communication devices (ETCDs) are used to aid communication in the later stages of ALS. We sought to evaluate the effect of ETCDs on patient disability, quality of life (QoL), and user satisfaction, in a group of 35 regular ETCD users in late-stage ALS with tetraplegia and anarthria. The following scales were administered: 1) the Individually Prioritized Problem Assessment (IPPA) scale, in three conditions: without device, with ETCD and, when applicable, with an Eye Transfer (ETRAN) board; 2) the Psychosocial Impact of Assistive Devices Scale (PIADS); and 3) the Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST 2.0). With ETRAN, IPPA showed an increase in communicative abilities with respect to the condition without device, but ETCD produced a further significant increase. PIADS evidenced a large increase of QoL, and QUEST 2.0 showed high user satisfaction with ETCD use. In conclusion, ETCDs should be considered in late-stage ALS with tetraplegia and anarthria, since in these patients they can reduce communication disability and improve QoL
L'esegesi secondo gli esegeti
No full textThe paper considers the prefatory texts of about fifty exegetical works of the period from Ambrosius Autpertus to Paschasius Radbertus. They usually reflect on the role of the exegete in the Christian societas, on the divine inspiration that guides him and on the relationship with the patristic sources. From these themes emerges a strong awareness of the commentators: exegesis continues in history the divine revelation, the preaching of Christ and the apostles, the voice of the Fathers, and proposes itself as a guide for rulers. Another theme often touched upon is the material transmission of commentaries, with important information on how they were composed and transmitted: their diffusion was entrusted to the copies that the recipients themselves would make from the exemplar sent by the author and not to a mass reproduction. These texts were not disseminated as common reference tools, but intended for dialogue among a political-cultural élite (as confirmed by the existence of a number of "minor" commentaries that substantiated the practice of teaching and reading the Bible)
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