362 research outputs found
Cid Ricketts Sumner, author.
No full textCid Ricketts Sumner in camp, Eggert-Hatch River Expedition, 1955
Finding Aid for James Eggert Publications, 1964-2009
No full textJames Eggert is an author and an emeritus teacher of economics at the University of Wisconsin Stout. Prior to joining the staff at the University in 1968, he served from 1964-1966 in the United States Peace Corps.This collection consists of books authored by Jim Eggert as well as the early drafts and completed book "Wonder of the Tao.
The Hidden Role of Non-Canonical Amyloid β Isoforms in Alzheimer’s Disease
No full textRecent advances have placed the pro-inflammatory activity of amyloid β (Aβ) on microglia cells as the focus of research on Alzheimer’s Disease (AD). Researchers are confronted with an astonishing spectrum of over 100 different Aβ variants with variable length and chemical modifications. With the exception of Aβ1-42 and Aβ1-40, the biological significance of most peptides for AD is as yet insufficiently understood. We therefore aim to provide a comprehensive overview of the contributions of these neglected Aβ variants to microglia activation. First, the impact of Aβ receptors, signaling cascades, scavenger mechanisms, and genetic variations on the physiological responses towards various Aβ species is described. Furthermore, we discuss the importance of different types of amyloid precursor protein processing for the generation of these Aβ variants in microglia, astrocytes, oligodendrocytes, and neurons, and highlight how alterations in secondary structures and oligomerization affect Aβ neurotoxicity. In sum, the data indicate that gene polymorphisms in Aβ-driven signaling pathways in combination with the production and activity of different Aβ variants might be crucial factors for the initiation and progression of different forms of AD. A deeper assessment of their interplay with glial cells may pave the way towards novel therapeutic strategies for individualized medicine
On the Sherlocks, Jane Coleman and County Kildare in the Eighteen Forties
No full textIn the late 1980s and early 1990s the author acquired about 30,000 letters written mainly in the 1840s. These pertained to estates throughout Ireland managed by the firm of James Robert Stewart and Joseph Kincaid, hereafter denoted SK. Until the letters – called the SK correspondence in what follows – became the author’s property, they had not seen light of day since the 1840s. Addressed mainly to the firm’s office in Dublin, they were written by landlords, tenants, the partners in SK, local agents, etc. After about 200 years in operation as a land agency, the firm in which members of the Stewart family were the principal partners – Messrs J. R. Stewart & Son(s) from the mid- 1880s onwards – ceased operations in the mid-1980s. Since 1994 the author has been researching the SK correspondence of the 1840s. It gives many new insights into economic and social conditions in Ireland during the decade of the great famine, and into the operation of Ireland’s most important land agency during those years. It is intended ultimately to publish details on several of the estates managed by SK in a study more comprehensive than the present article, in book form. The proposed title is Landlords, tenants, famine: business of an Irish land agency in the 1840s, a draft of which has now been completed. A majority of the letters in that study are on themes some of which one might expect - rents, distraint (seizure of assets in lieu of rent); ‘voluntary’ surrender of land in return for ‘compensation’ upon quitting quietly; formal ejectment (a matter of last resort on estates managed by SK); landlordassisted emigration (on a scale much more extensive than most historians of Ireland in the 1840s appear to believe); petitions from tenants; complaints by tenants, both about other tenants and about local agents; landlord-financed and other relief of distress both before and during the great famine; major works of improvement (on almost all of the estates managed by SK which have been investigated in detail in the draft book); applications by SK, on behalf of landlords, for government loans to finance improvements; recommendations of agricultural advisers hired by SK, etc. Thus, most of the SK correspondence is about aspects of estate management. But the firm of SK was not only a manager of land. The correspondence reveals only two estates in Kildare, each of them relatively small, managed by SK in the 1840s. These were the lands of the Sherlocks near Naas and of Jane Coleman in the Kilcullen district. The correspondence on these properties differs substantively from most of those discussed in detail in the draft of Landlords, tenants, famine: first, it is relatively small in quantity, and secondly, it contains relatively little on the core aspects of estate management indicated above. Much of that on the Sherlocks focuses on misfortunes among family members, while the correspondence on Jane Coleman highlights the benevolence of that proprietor.
Split Mountain to Green River, Utah. [Cid Sumner on boat "Brontosaur," Green River, Utah]
No full textPhoto of author Cid Sumner, passenger on a raft at Green River, Utah, during the Eggert-Hatch expedition in 195
On the River, Cid Ricketts Sumner on boat.
No full textPhoto of author Cid Ricketts Sumner on a boat with the Eggert-Hatch river expedition down the Green and Colorado Rivers in 195
Analysis of watersheds and river systems: short course
No full textShort course: Analysis of Watersheds and River Systems, Session I and II, held on May 28-June 1, 1979 and June 4-June 8, 1979 at Colorado State University, Fort Collins, Colorado.Speakers: Dr. E. V. Richardson, Dr. David Duttweiller, Mr. Lee Mulkey, Dr. Stanley A. Schumm, Dr. Daryl B. Simons, Dr. Ross Carder.Includes bibliographical references.This short course is designed for individuals dealing with the analysis of watersheds and rivers. Practical applications concerning physical processes will be emphasized.Chapter 1. General introduction / Daryl B. Simons and Ruh-Ming Li -- Chapter 2. Introduction to watershed and river analysis / Daryl B. Simons and Ruh-Ming Li -- Chapter 3. Physical processes governing response of watersheds and rivers / Daryl B. Simons, Timothy J. Ward and Ruh-Ming Li -- Chapter 4. Sediment transport / H. W. Shen -- Chapter 5. Alluvial bed roughness / H. W. Shen -- Chapter 6. Overview of flood routing methods / Ruh-Ming Li and V. Miguel Ponce -- Chapter 7. Water routing and yield from watersheds, Part I and II / Ruh-Ming Li, Daryl B. Simons, and Kenneth G. Eggert -- Chapter 8. Water routing in rivers / Yung-Hai Chen -- Chapter 9. Stage discharge relations / Robert K. Simons, Ruh-Ming Li, and Daryl B. Simons -- Chapter 10. Watershed sediment yield / Ruh-Ming Li, Daryl B. Simons, and Timothy J. Ward -- Chapter 11. Unsteady sediment routing models in rivers / Yung-Hai Chen and Daryl B. Simons -- Chapter 12. Known discharge sediment routing / Glenn O. Brown and Ruh-Ming Li -- Chapter 13. Landslide potential delineation / Timothy J. Ward, Ruh-Ming Li, and Daryl B. Simons -- Chapter 14. Application of Kalman filtering in watershed and river analysis / Nguyen Duong -- Chapter 15. Handheld calculator programs for analysis / Kenneth G. Eggert, Ruh-Ming Li, and Daryl B. Simons -- Chapter 16. Overview of case studies and data management / Daryl B. Simons, Ruh-Ming Li, and Nguyen Duong -- Chapter 17. Canal and channel design and river response analysis / Daryl B. Simons, Ruh-Ming Li, and Yung-Hai Chen -- Chapter 18. Degradation and aggradation analysis / Ruh-Ming Li and Daryl B. Simons -- Chapter 19. Watershed best management analysis / Ruh-Ming Li, Timothy J. Ward, and Daryl B. Simons -- Chapter 20. Large river basin analysis: Yazoo River Sedimentation Study / Daryl B. Simons and Ruh-Ming Li
From print to digital: A web edition of Giacomo Leopardi’s Idilli
No full textAlthough most would agree that the future of the scholarly edition lies in the digital
medium, it is the print scholarly edition that is still more often cited and read. The
production of digital scholarly editions (DSEs) is still seen as an experimental field whose
methodology has not yet settled to the extent that a digital editing project can be
approached with the same confidence as the making of a print edition. This article
describes an experimental conversion of a print scholarly edition—Giacomo
Leopardi’s Idilli by Paola Italia (2008)—into a DSE. This posed a challenge due to the
the complexity of its internal evidence, but was also relatively short and suitable for an
experimental edition. Our objective was to assimilate into a web-based DSE all the information contained in the text and apparatus of the print edition. We also sought to
discover whether the making of a DSE today that could fully utilize the affordances of the
web, would necessarily place a significant technical load on editors who are more accustomed to solving textual problems. We review briefly a number of generic tools for
making DSEs and describe two attempts at making our own DSE of Leopardi’s Idilli: a
wiki edition whose primary purpose was pedagogical and a DSE based on the software
used to make the Charles Harpur Critical Archive (Eggert, 2019, Charles Harpur Critical
Archive. http://charles-harpur.org). We compare these experiences and draw conclusions about the prospects of making DSEs today
Professoras negras e suas autorias: um estudo sobre a produção acadêmica de doutoras negras atuantes em universidades públicas do sul do Rio Grande do Sul
No full textEsta tese está inserida na linha de pesquisa Teorias e Culturas em Educação, do Programa de Pós-Graduação em Educação da Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), e teve como objetivo geral analisar como a produção científica das professoras doutoras negras, atuantes em cursos das áreas humanas, apresenta indícios da consciência da negritude por meio de elementos autobiográficos nos seus escritos. A metodologia adotada foi a autobiográfica que, aliada a escrevivência, permitiu que minha narrativa de vida também estivesse presente na pesquisa. Como uma mulher negra e professora, essas escolhas metodológicas também atuam como uma tentativa de rompimento com paradigmas universalizantes, androcêntricos, racistas e sexistas. Assim como a decisão de priorizar autoras mulheres, especialmente as negras, para a construção do referencial teórico utilizado neste trabalho — uma vez que esse estudo surgiu a partir da constatação da invisibilidade das mulheres negras no meio acadêmico. Foram consideradas para a investigação as categorias: gênero, raça, fator geográfico, habilitação e docência em instituições públicas, na área das ciências humanas.Para a análise da produção científica pude contar com a colaboração de três professoras doutoras, sendo elas: Giane Vargas Escobar, Sátira Pereira Machado e Simone Silva Alves. E a partir da investigação da produção acadêmica das três participantes (disponível de forma pública no Currículo Lattes) foi possível a construção das categorias: consciência da negritude, feminismo negro, dororidade, invisibilidade, fala/voz, resistência e combate ao racismo, que foram analisadas de acordo com o pensamento de intelectuais negras/os. Como resultado, os achados incluíram a indissociabilidade da negritude na produção acadêmica, a resistência e o combate ao racismo e a misoginia, assim como qualquer outra forma de preconceito ou discriminação.This thesis has the general objective of analyzing how the scientific production of black doctoral professors working in courses in the humanities áreas, presentes evidence of the consciousness of blackness through autobiographical elements in his writings. The methodology adopted was autobiographical allied to writing and a black woman teacher my life narrative is also related to this research it was a choice that signals the break with universalizing paradigms androcentric, racists and sexists, and for that, women authors, especially black women, were prioritized in the theoretical framework, since this study emerged from the observation of the invisibility of black women in the academic environment. Taking into account the categories of gender, race, geographic factor, qualification and teaching in public institutions in the area of human sciences, we had the collaboration of the doctors professors: Giane Vargas Escobar, Sátira Pereira Machado e Simone Silva Alves.The analysis of their academic productions publicity available in the Lattes Curriculum gave rise to the categories consciousness of blackness black feminism dorority, invisibility speaks resistance and combating racism that were analyzed according to the thinking of black intellectuals. The findings included the inseparability of blackness in academic production, resistance and the fight against racism and misogyny as well as any other form of prejudice or discrimination
APP family member dimeric complexes are formed predominantly in synaptic compartments
No full textAbstract Background The amyloid precursor protein (APP), a key player in Alzheimer’s disease (AD), is part of a larger gene family, including the APP like proteins APLP1 and APLP2. They share similar structures, form homo- and heterotypic dimers and exhibit overlapping functions. Results We investigated complex formation of the APP family members via two inducible dimerization systems, the FKBP-rapamycin based dimerization as well as cysteine induced dimerization, combined with co-immunoprecipitations and Blue Native (BN) gel analyses. Within the APP family, APLP1 shows the highest degree of dimerization and high molecular weight (HMW) complex formation. Interestingly, only about 20% of APP is dimerized in cultured cells whereas up to 50% of APP is dimerized in mouse brains, independent of age and splice forms. Furthermore, we could show that dimerized APP originates mostly from neurons and is enriched in synaptosomes. Finally, BN gel analysis of human cortex samples shows a significant decrease of APP dimers in AD patients compared to controls. Conclusions Together, we suggest that loss of full-length APP dimers might correlate with loss of synapses in the process of AD
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