382 research outputs found
FIGURES 16–19 in The first Turcolana Argano & Pesce, 1980 (Isopoda: Cirolanidae) from the Greek mainland
No full textFIGURES 16–19. Turcolana lepturoides sp. nov., holotype (♂, 10 mm): 16, uropod. 17, pereopod 1. 18, pereopod 2 with extensive propodial organ. 19, pereopod 6.Published as part of Prevorčnik, Simona, Konec, Marjeta & Sket, Boris, 2016, The first Turcolana Argano & Pesce, 1980 (Isopoda: Cirolanidae) from the Greek mainland, pp. 125-136 in Zootaxa 4170 (1) on page 134, DOI: 10.11646/zootaxa.4170.1.6, http://zenodo.org/record/25730
Uptake of CCR7 by KIR2DS4+ NK Cells Is Induced upon Recognition of Certain HLA-C Alleles
No full textThe KIR2DS4 receptor is the oldest KIR2DS expressed by human NK lymphocytes. The specificity of recognition of this receptor for various HLA class I alleles has been demonstrated; however it remains poorly understood whether these interactions may result in the activation of some specific functions in NK cells. Here, we examined the functional outcome of the KIR2DS4/HLA class I interaction by the use of an alternative functional system based on the ability of KIR2DS4 to regulate the mechanism of trogocytosis by NK cells. We demonstrate that KIR2DS4 can induce the uptake of CCR7 by KIR2DS4+ NKG2A+ NK cell clones after interacting with CCR7+ target cells expressing HLA-Cw4 and HLA-Cw6 alleles. However this interaction is not always sufficient to override the inhibition generated by NKG2A expressed on the same NK cells. The recognition of HLA-Cw4 was confirmed by experiments of cytotoxicity against HLA-C-transfected cells. We also show that, different from resting NK cells, the acquisition of CCR7 in response to IL-18 cannot occur in IL2-activated NK cells because of a marked downregulation in their IL-18Rα expression. As a consequence trogocytosis represents the major mechanism by which KIR2DS4+ activated NK cells acquire the expression of this chemokine receptor
Entrevista a Giovanni Pesce
No full textL�autor ens presenta l�entrevista a Giovanni Pesce, antic vetear italià que participà a la Guerra
d�Espanya amb les Brigades InternacionalsThe author shows in this paper the interview with Giovanni Pesce, old italian veteran that fought in the
Spanish Civil War as a member of the International Brigade
Entrevista a Giovanni Pesce
No full textL’autor ens presenta l’entrevista a Giovanni Pesce, antic vetear italià que participà a la Guerra d’Espanya amb les Brigades Internacionals.The author shows in this paper the interview with Giovanni Pesce, old italian veteran that fought in the Spanish Civil War as a member of the International Brigades
Temporary Office. First Act: il Mercato del Pesce di Genova.
No full textIl volume tratta l'esperienza del workshop intensivo Temporary Office svoltosi a Genova dal 10 al 17 novembre 2016 a cura di Valter Scelsi e Lorenzo Trompetto e sotto la direzione di Simona Malvezzi. Il workshop è dedicato all’ex Mercato del Pesce di piazza Cavour, alla sua storia e alle sue possibilità di riutilizzo e riconversione a nuove destinazioni d’uso. Oltre ai testi dei curatori - Antonio Lavarello, Luigi Mandraccio, Gian Luca Porcile, Valter Scelsi e Lorenzo Trompetto - il libro contiene i contributi di Benedetto Besio (Fondazione degli Architetti di Genova), Andrea Canziani (Soprintendenza Archeologia, Belle Arti e Paesaggio per la città metropolitana di Genova e le province di Imperia, La Spezia e Savona), Francesco Garutti (Canadian Centre for Architecture), Simona Malvezzi (Kuehn Malvezzi), Anna Positano (fotografa)
Celebrity and Vintage. The 1940s Seen Through Size and Style in "Allied"
No full textConstraint and desire for elegance are the contradictory meanings inherent in the apparel of the 1940s in Northern America and Great Britain, where wartime severity was balanced with a renewed feminine independence and an urban pursuit of self-refinement. In that decade sizes were invented, pairing style with industrial needs. A similar confluence of luxuries and restraints appears in contemporary Hollywood productions, perpetuating a well-established practice of integration of media and consumer culture. This is the case of Robert Zemekis’ film Allied, which recomposes a tension not only between voluptuousness and stern rigidity but also between exclusiveness and popularity. The film’s imaginary of the 1940s nostalgically resolves these conflicting motives drawing on a collective memory of the historical Hollywood star that amalgamates the narrative with purchasers’ behaviours reflecting the vintage mood. This allows a domestication of the star’s exuberance and seals Hollywood stars’ preeminence in the face of the inflation of celebrities and the multiplication of celebrity meaning
Double-compartment culture system for conditioning vascular grafts with different trans-wall oxygen levels
No full textRole of alloreactive KIR2DS1+ NK cells in haploidentical hematopoietic stem cell transplantation
No full textABSTRACT
In allo-HSCT, donor-derived, ″alloreactive″ NK cells have been shown to play a crucial role in the treatment of acute leukemia, contributing to eradication of leukemic blasts (GvL effect) and to clearance of residual recipient DCs and T lymphocytes (thus, preventing GvHD and graft rejection, respectively). Such alloreactive NK cells do not express CD94/NKG2A but express inhibitory KIRs, specific for HLA class I allotypes, present in the donor but lacking in the recipient. This review is focused on the role of the activating KIR2DS1 receptor (specific for the C2-epitope of HLA-C) in haplo-HSCT. Recent data indicate that KIR2DS1 expression in HSC donors may represent a remarkable advantage in alloreactive NK responses. This is a result of a substantial increase in the NK-mediated capability to kill, not only recipients' leukemic cells but also DCs and T cell blasts. The beneficial effects mediated by alloreactive KIR2DS1+ NK cells may occur after de novo expression of CCR7 upon interaction with allogeneic, KIR ligand-mismatched CCR7+ cells. As a consequence, they can be redirected to LNs, where they can prevent priming of donor T cells and induction of GvHD. Finally, KIR2DS1 expression may also significantly amplify the size of the alloreactive NK cell subset by switching a subset of “not alloreactive” NK cells into potent alloreactive cells.</jats:p
NK/DC Crosstalk in Anti-viral Response
No full textIn recent years, it has been emphasized the role of the crosstalk between natural killer (NK) cells and monocyte-derived dendritic cells dendritic cells (moDCs) in the regulation of the early phases of innate immunity innate immunity and of the subsequent adaptive immune responses. NK cells and DCs coordinate their response communicating through direct cell-to-cell contact and soluble factors. NK cells appear to contribute to the quality control of immature DCs (iDCs) undergoing maturation. On the other hand, DCs may shape the magnitude of innate immune responses by modulating the NK-mediated cytolytic activity against tumors or infected cells. Recent studies suggest that the cooperation between NK cells and DCs is also critical in several anti-viral responses. In particular, NK cells are capable of effectively counteracting viral immune evasion immune evasion strategies by eliminating infected DCs, that display impaired antigen presenting functions, thus indirectly favoring the development of adaptive immune responses to viral antigens cross-presented by healthy DCs
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