60 research outputs found
Efficient Microwave and Phosphane-Free Synthesis of Trisubstituted Olefins via Heck Coupling
No full textEfficient Microwave and Phosphane-free Synthesis of Trisubstituted Olefins via Heck Coupling
No full textAR and VR in cultural institutions
No full textThe use of augmented, virtual and mixed reality (AR/VR/MR) to experience and perceive cultural heritage is less adopted by museums, libraries, archives and cultural institutions than other fields. There may be concerns that AR/VR have the potential to stop visitors from attending in person (Coates, 2020). However, in 2020, many museums have started to offer virtual tours of their collections during the global COVID-19 pandemic. This, in fact, has forced in different moments the closure of most museums and institutions. In the following reading, the difference between those digital technologies and why cultural institutions are using them now will be described.Heritage & Value
Nutritional Status and Potentially Inappropriate Medications in Elderly
No full text(1) Background: The association between polypharmacy and malnutrition has been investigated in several studies; however, few of these specifically deepened the relationship between potentially inappropriate medication and malnutrition. With a descriptive approach, the primary aim of our study was to evaluate the impact of the nutritional status, assessed with the Mini Nutritional Assessment (MNA), on potentially inappropriate medications (PIM), estimated 10-year survival, and the risk of adverse drug reactions in elderly patients; the secondary aim was to evaluate how the Screening Tool of Older People’s Prescriptions (STOPP), Screening Tool to Alert to Right Treatment (START), and BEERS 2019 criteria identify PIM compared to nutritional status. (2) Methods: In this study, 3091 subjects were enrolled, of whom 2748 (71.7%) were women; the median age was 80 years, with an interquartile range between 75 and 85 years of age. The subjects were assessed at the outpatient service for frail older people of the University Hospital of Cagliari. The study population was evaluated for their: MNA, Charlson Comorbidity Index, 10-year survival estimation, BEERS 2019, STOPP and START criteria, and ADR Risk scores. (3) Results: We divided the study population into three groups: MNA1 (MNA score ≥ 24), MNA2 (23.5–17), and MNA3 (<17): the severity of comorbidities, STOPP and START alerts, and BEERS 2019 criteria were significantly worse in both MNA2 and MNA3 compared to MNA1—with the exception of BEERS “non-anti-infective medications that should be avoided or have their dosage reduced with varying levels of kidney function in older adults”. Moreover, the estimated 10-year survival was significantly higher in MNA1 than in MNA2 and MNA3, and also in MNA2 compared to MNA3. Finally, the ADR risk scores were significantly lower in MNA1 than in MNA2 and MNA3. (4) Conclusions: Our study demonstrated the association between nutritional status and PIM checked with the BEERS 2019 criteria, and, for the first time, with the STOPP and START criteria
Microwave assisted synthesis of chiral pyrrolines with biological activity
No full textA new, high yield regioselective reaction affording racemic and enantiomeric 1,2-dimethyl-3-[2-(6-substituted naphthyl)]-2H,5H-pyrrolines is reported. Compounds were provided by dehydration of the corresponding 1,2-dimethyl-3-[2-(6-substitutednaphthyl)]-3-hydroxypyrrolidines under microwave irradiation and solvent-free conditions. Pharmacological properties of enantiomeric compounds are also described; the analgesic activity was investigated by the hot plate test. A conformational analysis of the compounds was carried out by molecular modeling techniques with the aim to get information about the fitting to known analgesic pharmacophore models
Evoluzione pedogenetica di una toposequenza di suoli sul plateau basaltico di Sedilo (Sardegna centrale)
No full textRisoluzione di ligandi selettivi sigma1 a struttura alchilamminoalchilarilica mediante HPLC chirale e studio configurazionale
No full textMicrowave Assisted Synthesis of Chiral Pyrrolinyl-Naphthalenes and evaluation of their Antinociceptive Activity
No full textDiastereoselective synthesis of chiral nonracemic naphthylaminoalcohols with analgesic activity
No full textAbstract—The diastereoselective synthesis of chiral nonracemic naphthylaminoalcohols has been accomplished. The diastereoisomers, obtained in high enantiomeric excesses, were investigated by 1H NMR and HPLC analyses. The configurational assignment was performed by NOESY 1H NMR spectroscopy. Pharmacological evaluation of the analgesic activity by means of the hot plate test is describe
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