4,395 research outputs found
John Stuart Mill’s projected science of society: 1827-1848
No full textThe purpose of the thesis is to examine John Stuart Mill’s political thought from
about 1827 to 1848 as an exercise in intellectual history. It focuses, first, on Mill’s view,
formulated by the late 1830s, that contemporary society was ‘civilized’, and second, on
his project of a science of society, which he aspired to develop in the late 1830s and
early 1840s.
By the late 1830s, Mill came to the view that his contemporary society was a
‘commercial society or civilization’, dominated by the middle, commercial class. The
first part of my thesis, constituted by Chapters 2-4, discusses the way in which Mill
formed his notion of civilization, and what he meant by the term ‘civilization’. Mill paid
attention to the implications of the rise of the middle class, and regarded such
phenomena of contemporary society as the corruption of the commercial spirit and
excessive social conformity as an inevitable consequence of the rise of the middle class.
The second part of the thesis, constituted by Chapters 5-9, examines Mill’s
projected science of society. In the late 1830s and early 1840s, Mill attempted to
develop a new science of society whose subject-matter was the nature and prospects of
commercial, civilized society. This aspiration culminated in A System of Logic,
published in 1843. In examining Mill’s projected science, I pay particular attention to
the fact that he conceived new sciences of history and of the formation of character,
both of which were indispensable in his project, although he failed to give a complete
account of these sciences. My thesis shows that the implications of his interest both in
history and in the formation of character are more significant than Mill scholars have
assumed
Stuart S. Miller. Studies in the History and Traditions of Sepphoris
No full textSchwarzfuchs Simon. Stuart S. Miller. Studies in the History and Traditions of Sepphoris. In: Revue de l'histoire des religions, tome 206, n°2, 1989. pp. 202-204
Fine-grained traffic state estimation and visualisation
No full textTools for visualising the current traffic state are used by local authorities for strategic monitoring of the traffic network and by everyday users for planning their journey. Popular visualisations include those provided by Google Maps and by Inrix. Both employ a traffic lights colour-coding system, where roads on a map are coloured green if traffic is flowing normally and red or black if there is congestion. New sensor technology, especially from wireless sources, is allowing resolution down to lane level. A case study is reported in which a traffic micro-simulation test bed is used to generate high-resolution estimates. An interactive visualisation of the fine-grained traffic state is presented. The visualisation is demonstrated using Google Earth and affords the user a detailed three-dimensional view of the traffic state down to lane level in real time
Welcoming Remarks
No full textStuart Rabinowitz President Andrew M. Boas and Mark L. Claster Distinguished Professor of Law Hofstra University
David Yellen Dean and Max Schmertz Distinguished Professor of Law Hofstra University School of Law
Roy D. Simon Professor of Law Director of the Institute for the Study of Legal Ethics Hofstra University School of Law Conference Co-Director Monroe H. Freedman Howard Lichtenstein Distinguished Professor of Legal Ethics Hofstra University School of Law Conference Co-Directo
Welcoming Remarks
No full textStuart Rabinowitz President Andrew M. Boas and Mark L. Claster Distinguished Professor of Law Hofstra University
David Yellen Dean and Max Schmertz Distinguished Professor of Law Hofstra University School of Law
Roy D. Simon Professor of Law Director of the Institute for the Study of Legal Ethics Hofstra University School of Law Conference Co-Director Monroe H. Freedman Howard Lichtenstein Distinguished Professor of Legal Ethics Hofstra University School of Law Conference Co-Directo
Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits
No full textThe transporter associated with antigen processing (TAP) supplies peptides into the lumen of the endoplasmic reticulum (ER) for binding by major histocompatibility complex (MHC) class I molecules. TAP comprises two polypeptides, TAP1 and TAP2, each a 'half-transporter' encoding a transmembrane domain and a nucleotide-binding domain. Immunoprecipitation of rat TAP1 and TAP2 expressed individually in the human TAP-deficient cell line, T2, revealed that both bound the endogenously expressed HLA-A2 and -B51 class I molecules. Using HLA-encoding recombinant vaccinia viruses HLA-A*2501, -B*2704, -B*3501 and -B*4402, alleles also associated with both TAP1 and TAP2. Thus, TAP1 and TAP2 do not appear to differ in their ability to interact with MHC class I alleles. Single TAP polypeptide subunits also formed MHC class I peptide-loading complexes, and their nucleotide-binding domains retained the ability to interact with ATP, and may permit the release of peptide-loaded MHC class I molecules in the absence of a peptide transport cycle. It is also demonstrated by chemical cross-linking that TAP2, but not TAP1, has the ability to form a homodimer complex both in whole cells and in detergent lysates. Together these data indicate that single TAP polypeptide subunits possess many of the features of the TAP heterodimer, demonstrating them to be useful models in the study of ATP-binding cassette (ABC) transporters
The oxidoreductase ERp57 efficiently reduces partially folded in preference to fully folded MHC class I molecules
No full textThe oxidoreductase ERp57 is an integral component of the peptide loading complex of major histocompatibility complex (MHC) class I molecules, formed during their chaperone-assisted assembly in the endoplasmic reticulum. Misfolded MHC class I molecules or those denied suitable peptides are retrotranslocated and degraded in the cytosol. The presence of ERp57 during class I assembly suggests it may be involved in the reduction of intrachain disulfides prior to retrotranslocation. We have studied the ability of ERp57 to reduce MHC class I molecules in vitro. Recombinant ERp57 specifically reduced partially folded MHC class I molecules, whereas it had little or no effect on folded and peptide-loaded MHC class I molecules. Reductase activity was associated with cysteines at positions 56 and 405 of ERp57, the N-terminal residues of the active CXXC motifs. Our data suggest that the reductase activity of ERp57 may be involved during the unfolding of MHC class I molecules, leading to targeting for degradation
Corrigendum: Pneumococcal vaccine impacts on the population genomics of non-typeable haemophilus influenzae: (Microbial Genomics 2021; 9, 10.1099/mgen.0.000209)
No full textThere was a change in the author names in the published article. The new list should read: David W. Cleary1,2, Vanessa T. Devine3, Denise E. Morris1, Karen L. Osman1, Rebecca A. Gladstone4, Stephen D. Bentley4, Saul N. Faust1,5, Stuart C. Clarke1,2,6 1Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK. 2NIHR Southampton Biomedical Research Centre, University Hospital Southampton Foundation NHS Trust, Southampton, UK. 3Northern Ireland Centre for Stratified Medicine and Clinical Translational Research Innovation Centre, Londonderry, UK. 4Pathogen Genomics, Wellcome Trust Sanger Institute, UK. 5NIHR Southampton Clinical Research Facility, University Hospital Southampton Foundation NHS Trust, Southampton, UK. 6Global Health Research Institute, University of Southampton, Southampton, UK.</p
The Life and Letters of the Lady Arbella Stuart
No full textLady Arbella Stuart, a woman nearly forgotten in history and literature and yet a woman who lived a full and exciting life which is well documented in her letters to her family, friends and royalty (both Queen Elizabeth I and James VI and I). Arbella Stuart was born in 1575 to Elizabeth Cavendish and Charles Darnley and was brought up by her maternal grandmother, Bess of Hardwick. She was educated from birth about her proximity to the throne (there was a chance she could have been queen when Elizabeth died) and the important role she had in life. There have been several biographies written about Stuart over the years and most recently an excellent text of her existing letters by Sara Jayne Steen which is the primary source of information for this thesis. This thesis examines Stuart’s tone, rhetoric and style in a selection of letters written over the course of her life, where possible using manuscripts viewed in the British Library and Hardwick Hall, as well as the published text. Part of what makes Stuart such an interesting subject is her ability to manipulate her reader and assume different personae, depending on whom she was writing to. The young Stuart writes passionately and often without thinking first, putting her thoughts on paper and then quickly sending them off to the Queen and her advisers. An older and wiser Stuart writes from James VI and I’s court and is very formal in her letters to the King. She is more relaxed when writing to her Aunt and Uncle and depicts court life in a lively informal fashion giving us a valuable insight into what life as a courtier would have been like at this time. Finally the thesis examines Stuart’s last letters written from imprisonment, the work of a desperate woman, fighting for her freedom. Stuart, like most of us, had a multi-faceted personality. She was at times an apparently submissive and subservient subject of the King; a well read and educated woman who adopted the guise of humility and deference to those in authority, the patriarchal order in place. This thesis will depict the many different sides to Stuart and give a brief overview of her exciting and turbulent life, told through her letters
Formation of HLA-B27 homodimers and their relationship to assembly kinetics
No full textThe human HLA-B27 class I molecule exhibits a strong association with the inflammatory arthritic disorder ankylosing spondylitis and other related arthropathies. Major histocompatibility complex class I heavy chains normally associate with 2-microglobulin and peptide in the endoplasmic reticulum before transit to the cell surface. However, an unusual characteristic of HLA-B27 is its ability to form heavy chain homodimers through an unpaired cysteine at position 67 in the peptide groove. Homodimers have previously been detected within the ER and at the cell surface, but their mechanism of formation and role in disease remain undefined. Here we demonstrate, in the rat C58 thymoma cell line and in human HeLa cells transfected with HLA-B27, that homodimer formation involves not only cysteine at position 67 but also the conserved structural cysteine at position 164. We also show that homodimer formation can be induced in the non-disease-associated HLA class I allele HLA-A2 by slowing its assembly rate by incubation of cells at 26 °C, suggesting that homodimer formation in the endoplasmic reticulum may occur as a result of the slower folding kinetics of HLA-B27. Finally, we report an association between unfolded HLA-B27 molecules and immunoglobulin-binding protein at the cell surface
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