4,720 research outputs found
Physical function in patients with cancer: psychometric characteristics and clinical usefulness of a physical performance test battery
No full textThis study investigated the psychometric properties of a battery of physical performance tests, characterized physical function in patients with cancer referred for rehabilitation, and provided normative standards against which to compare disease progression and/or future treatment effectiveness. A total of 109 patients with cancer (55 women and 54 men) and 105 control subjects (66 women and 39 men) participated. Subjects completed self-report questionnaires regarding pain, physical function, and fatigue, and also performed nine physical performance tests: the time taken to complete various tasks (picking up coins, tying a belt, reaching up, putting on a sock, standing from sitting, a 50-foot fast walk, a 50-foot walk at preferred speed), the distance walked in 6 minutes, and the distance reached forward while standing were measured. Inter-tester and test-retest reliability was good to excellent for all tests (ICC(11) 0.69 to 0.99). Known group analyses controlling for age were significant (P < 0.001) for all physical performance tests. Control subjects significantly and systematically outperformed those with cancer by a factor of two or three. Examination of the correlation matrices showed relatively low correlations between performance and external measures (r = 0.01 to 0.45). In contrast, correlations among performance measures were generally in the range of r = 0.25 to 0.85. Correlations between self-report of function and performance of functional tests were moderate, suggesting that the two methods of measuring function are complementary and both should be used for assessment and as outcome measure
Children experiencing happiness in the city
No full textThis chapter highlights the key role of the local urban space as part of children and adolescent´s everyday experiences of happiness. By identifying the meaningful places where children locate their everyday experiences, it examines how children and young people experiences of happiness relate to their urban surroundings. By using an experiential approach, it discusses the role of the city in terms of both the evidence of the physical environment as well as the emotional attachment to it in terms of sociability, safety, accessibility and quality of the built environment. In doing so, it argues the happiness experience is not universal, but rather context dependent. The findings are based on a robust research programme conducted in Lima, Peru, comprising a qualitative stage with 200 children followed by a quantitative in-school survey with 700 respondents, in both cases aged 8-16 and sampled from different social economic groups and geographical areas of the city. Fundamentally, the chapter provides relevant insights into how young people experience happiness and the city within the particular, social complexities of Latin America
Vacuum Insulation Panels Applied in Building Constructions
No full textDue to sustainability and due to international treaties, it is desired and required to reduce greenhouse gas emissions drastically. One contributor to these emissions is the burning of fossil fuels for generating power and electricity to be used in and for buildings. Buildings and building-related processes are responsible for about 40% of the primary energy consumption in the European Union. More than half of this energy is applied for heating systems in dwellings and commercial buildings. The European Union therefore has laid down new energy performance requirements for buildings in the European Directive on the Energy Performance of Buildings. Moreover, a reduction of energy losses of buildings during their occupational phase is important for facilitating the implementation of sustainable energy sources in the built environment. Increasing the insulation value of the envelope of buildings may contribute to this reduction of primary energy use. Two strategies can be followed. The first strategy is to increase the thickness of the thermal insulation layer. Until recently, this strategy has primarily been adopted. If, however, German or Swiss Passivhaus standard is applied, the thickness of this insulation layer would increase to beyond 30 cm, resulting in very thick building enclosures. The second, more innovative, strategy for reducing energy losses through the building skin would be the application of more effective thermal insulators. One such more effective thermal insulator is a vacuum insulation panel, abbreviated as VIP. A VIP consists of an open-celled core material which is evacuated and then tightly sealed into a barrier envelope to maintain this vacuum. The vacuum inside the pores of the core material reduces the thermal conductivity of the product significantly, as a result of which the thickness of the insulation layer can be reduced to obtain a certain performance. This reduction of thickness is among the most promising features for large-scale application of VIPs in the building industry. However, integration of VIPs into buildings must be performed very meticulously for several reasons; first, due to its nature a VIP cannot be processed on site and needs careful planning in advance; second, it is very sensitive to mechanical damage thus requiring careful handling; third, thermal bridges along the panel’s edges reduce its performance; fourth, the composite system is highly subjected to aging. This dissertation therefore looks into many of these aspects, presents several calculation tools and shows how VIPs can be applied in façade panels, EPS insulation boards and as under-floor insulation. With the wide-spread proliferation of VIPs in buildings a more sustainable and healthy environment can then be achieved.Building TechnologyArchitectur
Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses:Implications for virus evolution and host persistence
No full textDiscrete RNA secondary and higher-order structures, typically local in extent, play a fundamental role in RNA virus replication. Using new bioinformatics analysis methods, we have identified genome-scale ordered RNA structure (GORS) in many genera and families of positive-strand animal and plant RNA viruses. There was remarkably variability between genera that possess this characteristic; for example, hepaciviruses in the family Flaviviridae show evidence for extensive internal base-pairing throughout their coding sequences that was absent in both the related pestivirus and flavivirus genera. Similar genus-associated variability was observed in the Picornaviridae, the Caliciviridae, and many plant virus families. The similarity in replication strategies between genera in each of these families rules out a role for GORS in a fundamentally conserved aspect of this aspect of the virus life cycle. However, in the Picornaviridae, Flaviviridae, and Caliciviridae, the existence of GORS correlated strongly with the ability of each genus to persist in their natural hosts. This raises the intriguing possibility of a role for GORS in the modulation of innate intracellular defense mechanisms (and secondarily, the acquired immune system) triggered by double-stranded RNA, analogous in function to the expression of structured RNA transcripts by large DNA viruses. Irrespective of function, the observed evolutionary conservation of GORS in many viruses imposes a considerable constraint on genome plasticity and the consequent narrowing of sequence space in which neutral drift can occur. These findings potentially reconcile the rapid evolution of RNA viruses over short periods with the documented examples of extreme conservatism evident from their intimate coevolution with their hosts
Book Review: Reginald M.J. Oduor’s Introduction to Ethics
No full textTITLE OF BOOK: Introduction to Ethics
AUTHOR: Reginald M.J. Oduor
Nairobi: Sophia Publications Ltd., 2009, 116 pages
COVER: Paperback
ISBN: 9966-7457-0-X
This book is a product of more than a decade of Oduor’s experience in teaching ethics (moral philosophy) at the University of Nairobi. In the course of this introduction, the reader gets to see the techniques of philosophic reflection in action, as they are employed to scrutinise various pertinent moral questions
Comments on “Precipitation kinetics of Al–1.12Mg2Si–0.35Si and Al–1.07Mg2Si–0.33Cu alloys”
No full textIt is shown that in analysing DSC data of precipitation reactions in Al–1.12Mg2Si–0.35Si, Al–1.07Mg2Si–0.33Cu and Al–1.0Mg2Si–0.5Ag alloys in work by Gaber et al., accurate values for the activation energies are obtained by applying the method derived by the present author (the Type B-1.92 method). Values obtained from other analysis methods reported by Gaber et al. are less accurate. Averaging activation energies obtained by different methods introduces inaccuracies and obscures these inaccuracies, especially if the set of methods applied includes highly inaccurate ones, such as the Ozawa and Takhor methods
Treadmill interface for virtual reality vs. overground walking: a comparison of gait in individuals with and without pain
No full textOptical Flow Based State Estimation for an Indoor Micro Aerial Vehicle
No full textThis work addresses the problem of indoor state estimation for autonomous flying vehicles with an optic flow approach. The paper discusses a sensor configuration using six optic flow sensors of the computer mouse type augmented by a three-axis accelerometer to estimate velocity, rotation, attitude and viewing distances. It is shown that the problem is locally observable for a moving vehicle. A Kalman filter is used to extract these states from the sensor data. The resulting approach is tested in a simulation environment evaluating the performance of three Kalman filter algorithms under various noise conditions. Finally, a prototype of the sensor hardware has been built and tested in a laboratory setup. Paper published: Verveld, M.J., Chu, Q.P., De Wagter, C. and Mulder, J.A. “Optic Flow Based State Estimation for an Indoor Micro Air Vehicle” AIAA Guidance, Navigation, and Control Conference, August 2010, Toronto, Canada AIAA 2010-8209, DOI: 10.2514/6.2010-8209Aerospace EngineeringControl & Simulatio
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