5,758 research outputs found
Personal Papers (MS 80-0002)
No full textLetter from Isaac H. Kempner to A. C. Simmonds, Jr. discussing not hearing back about life insurance stocks and plans to visit New York
Personal Papers (MS 80-0002)
No full textLetter from A. C. Simmonds, Jr. to I. H. Kempner discussing the address Simmonds is delivering at the upcoming Texas Bankers Association Convention
Personal Papers (MS 80-0002)
No full textLetter from Albert C. Simmonds, Jr. to Isaac H. Kempner informing the latter that he passed his life insurance questions to an associate more familiar with it
Personal Papers (MS 80-0002)
No full textLetter from Albert C. Simmonds, Jr. to Daniel W. Kempner thanking him for the kind offer to let him stay at his house while in Galveston for the Texas Bankers Association convention, but explaining that he has prior commitments
Personal Papers (MS 80-0002)
No full textLetter from Isaac H. Kempner to A. C. Simmonds, Jr. discussing his interest in the stock market and requesting an opinion on what life insurance companies would make good investments
Personal Papers (MS 80-0002)
No full textLetter from Isaac H. Kempner to A. C. Simmonds, Jr. thanking for the tribute to the Alexander Hamilton bank
Personal Papers (MS 80-0002)
No full textLetter from Isaac H. Kempner to A. C. Simmonds, Jr. informing that he had received the paper weight regarding the 100th anniversary of the firm
Personal Papers (MS 80-0002)
No full textLetter from Isaac H. Kempner to Albert C. Simmonds, Jr. informing that Lyda Ann Thomas sent a clipping from the New York Times
26th Annual African American Living Legends Series - Etta James, Clinton Tatum, Jr., and [unknown]
No full textSinger, author, and event honoree Etta James (seated) with Deputy Supervisor Clinton Tatum, Jr. (right) and [unknown] (rear)
Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses:Implications for virus evolution and host persistence
No full textDiscrete RNA secondary and higher-order structures, typically local in extent, play a fundamental role in RNA virus replication. Using new bioinformatics analysis methods, we have identified genome-scale ordered RNA structure (GORS) in many genera and families of positive-strand animal and plant RNA viruses. There was remarkably variability between genera that possess this characteristic; for example, hepaciviruses in the family Flaviviridae show evidence for extensive internal base-pairing throughout their coding sequences that was absent in both the related pestivirus and flavivirus genera. Similar genus-associated variability was observed in the Picornaviridae, the Caliciviridae, and many plant virus families. The similarity in replication strategies between genera in each of these families rules out a role for GORS in a fundamentally conserved aspect of this aspect of the virus life cycle. However, in the Picornaviridae, Flaviviridae, and Caliciviridae, the existence of GORS correlated strongly with the ability of each genus to persist in their natural hosts. This raises the intriguing possibility of a role for GORS in the modulation of innate intracellular defense mechanisms (and secondarily, the acquired immune system) triggered by double-stranded RNA, analogous in function to the expression of structured RNA transcripts by large DNA viruses. Irrespective of function, the observed evolutionary conservation of GORS in many viruses imposes a considerable constraint on genome plasticity and the consequent narrowing of sequence space in which neutral drift can occur. These findings potentially reconcile the rapid evolution of RNA viruses over short periods with the documented examples of extreme conservatism evident from their intimate coevolution with their hosts
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