88,738 research outputs found
The San On map of Mgr. [i.e. Monsigneur] Volonteri [cartographic material] : map of the San-On District (Kwangtung Province) : drawn from actual observations made by an Italian Missionary of the Propaganda in the course of his professional labors during a period of four years : being the first and only map hitherto published, May 1866 /
No full textMap of the San-On district within the Kwangtung Province and featuring the city of Hong Kong following British occupation in 1841. Place names are given in both Roman and Chinese scripts.; In 1860 Monsigneur Simeone Volonteri joined the Mission of the Propaganda in the Roman Catholic Diocese of Hong Kong and while there produced this map.; "The uncertain pronunciation of the Chinese characters is fixed according to Williams's Dictionary".; Originally published anonymously in 1866 as: Map of the San-On District (Kwangtung Province).; Reproduction of the original held by the National Library of Australia at call number: Map RM 279.; Also available online: http://nla.gov.au/nla.map-vn3426318.Map of the San-On District (Kwangtung Province
Aspirin in primary prevention: the triumph of clinical judgement over complex equations
No full textAspirin, in 2017, has celebrated its 120th birthday. The efficacy and safety of low-dose aspirin in secondary prevention of cardiovascular disease is well supported by many studies, instead in primary prevention it remains controversial, especially in the aftermath of the publication in 2018 of three novel primary prevention randomized clinical trials, showing that the benefit of low-dose aspirin, although additive to that of statin, is counterbalanced by an excess of (mainly gastrointestinal) bleeding events. The signal for a net benefit seems to be even more controversial in the elderly starting aspirin after the age of 70 years. While international guidelines have promptly downgraded their recommendations to more conservative indications, the practicing clinician is called to make the effort to individualize the treatment, after careful evaluation of the haemorrhagic risk vis-a-vis the risk to develop, in the mid-term and long-term follow-up, major cardiovascular events or cancer. This is a particularly complex task, given the different immediate and long-term impact of diverse outcomes on health, the dynamic nature over time of the benefit/risk balance, prompting periodic re-assessments of its indication, and the interindividual variability in aspirin response. The chemopreventive properties of aspirin, anticipated by a large body of epidemiological and mechanistic evidence, are awaiting their final confirmation by the long-term follow-up of the latest trials specifically designed to assess this endpoint, with the expectation to subvert the delicate benefit/risk balance of aspirin in primary prevention. This review is intended to provide an interpretation of past and current evidence to guide clinical decision making on the contemporary patient
Community-acquired pneumonia therapy: The beta-lactam and macrolide combination has no advantages over the use of beta-lactam alone
No full textIl risultato delle studio esaminato, rispetto
all’obiettivo principale, conferma che l’uso combinato
della terapia con macrolide e beta-lattamico in tutti i casi
di CAP non ha portato alcun vantaggio rispetto all’uso in
monoterapia del solo beta-lattamico1. Pertanto al fine di
un uso giudizioso degli antibiotici anche nella gestione
della broncopolmonite ci si dovrebbe attenere alle LG del
la British Thoracic Society e della Infectious Diseases So
ciety of America2,3, che prevedono l’utilizzo del macrolidi
solo in casi ben definiti. In sostanza, i macrolidi non do
vrebbero essere utilizzati come antibiotici di prima scelta
nei casi di CAP, ma possono essere considerati a qualsiasi
età se non c’è una chiara risposta alla terapia empirica di
prima linea con amoxicillina o quando si ha una ragione
vole certezza (per età, caratteristiche epidemiologiche o
cliniche) che si tratti di una infezione da Mycoplasma,
come la LG americana sembra suggerire. Il macrolide an
drebbe considerato da subito in aggiunta al beta-lattamico
nei casi di bambini ricoverati con polmonite severa
Spazio endodontico e contaminazione batterica: il successo clinico tra chimica e meccanica
No full textOn the use of a visco-plastic sliding-law for prevailing longitudinal dimension slow landslides
No full textThis paper presents and discusses the use of a mechanical model based on a visco-plastic sliding law for the study of the kinematic features of prevailing longitudinal dimension slow landslides. The model correlates sliding velocity and effective stress along the shear surface. An application to a case history is also presente
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