177 research outputs found
"Isozyme variation in ""helminthosporium-type"" species pathogenic on maize"
No full textThe population structure of three species of fungi pathogenic on Zea mays L.; Cochliobolus carbonum, C. heterostrophus, and Septosphaeria turcica were studied using isozyme analysis. Forty isolates of S. turcica were evaluated using nineteen enzyme stains. Polymorphisms were identified with aspartate aminotransferase (EC 2.6.1.1), fumarase (EC 4.2.1.2), glucose-6-phosphate dehydrogenase (EC 1.1.1.49), and mannose-6-phosphate isomerase (EC 5.3.1.8). Associated electrophoretic and virulence phenotypes were found, indicating that populations exist in S. turcica as asexually propagated clonal groups. Use of the UPGMA method to calculate overall similarity between isolates found that isolates of race 1 were more similar to race 2 than isolates of race 3.Isolates of C. carbonum were found to be polymorphic for aspartate aminotransferase, esterase (EC 3.1.1), glucose phosphate isomerase (EC 5.3.1.9), leucine aminopeptidase (EC 3.4.11), and mannitol dehydrogenase. Races of C. carbonum were found to be associated with specific electrophoretic phenotypes. Phenograms generated by the UPGMA method showed similarity between races 1 and 3, which are highly virulent on maize. Both races were less similar to isolates of race 2, a weak pathogen of maize. No isozyme polymorphisms were detected in isolates of race 0 of C. heterostrophus. One race T isolate showed polymorphisms with esterase and hexokinase.Made available in DSpace on 2011-05-07T12:12:09Z (GMT). No. of bitstreams: 2
license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5)
8924943.pdf: 1906453 bytes, checksum: a4305176ce990b4d9fe28b957275598b (MD5)
Previous issue date: 1989Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding ([email protected]) on 2011-05-07T14:38:01Z
Item is restricted indefinitely.Restriction data tranferred 2014-07-01T11:15:45-05:00
Original Data
Group with Access UIUC Users [automated]
Release Date: none
Reason: ETDs are only available to UIUC Users without author permissionETDs are only available to UIUC Users without author permissionU of I Onl
Functional Data Analysis Applied to Modeling of Severe Acute Mucositis and Dysphagia Resulting From Head and Neck Radiation Therapy
No full textPurposeCurrent normal tissue complication probability modeling using logistic regression suffers from bias and high uncertainty in the presence of highly correlated radiation therapy (RT) dose data. This hinders robust estimates of dose-response associations and, hence, optimal normal tissue–sparing strategies from being elucidated. Using functional data analysis (FDA) to reduce the dimensionality of the dose data could overcome this limitation.Methods and MaterialsFDA was applied to modeling of severe acute mucositis and dysphagia resulting from head and neck RT. Functional partial least squares regression (FPLS) and functional principal component analysis were used for dimensionality reduction of the dose-volume histogram data. The reduced dose data were input into functional logistic regression models (functional partial least squares–logistic regression [FPLS-LR] and functional principal component–logistic regression [FPC-LR]) along with clinical data. This approach was compared with penalized logistic regression (PLR) in terms of predictive performance and the significance of treatment covariate–response associations, assessed using bootstrapping.ResultsThe area under the receiver operating characteristic curve for the PLR, FPC-LR, and FPLS-LR models was 0.65, 0.69, and 0.67, respectively, for mucositis (internal validation) and 0.81, 0.83, and 0.83, respectively, for dysphagia (external validation). The calibration slopes/intercepts for the PLR, FPC-LR, and FPLS-LR models were 1.6/−0.67, 0.45/0.47, and 0.40/0.49, respectively, for mucositis (internal validation) and 2.5/−0.96, 0.79/−0.04, and 0.79/0.00, respectively, for dysphagia (external validation). The bootstrapped odds ratios indicated significant associations between RT dose and severe toxicity in the mucositis and dysphagia FDA models. Cisplatin was significantly associated with severe dysphagia in the FDA models. None of the covariates was significantly associated with severe toxicity in the PLR models. Dose levels greater than approximately 1.0 Gy/fraction were most strongly associated with severe acute mucositis and dysphagia in the FDA models.ConclusionsFPLS and functional principal component analysis marginally improved predictive performance compared with PLR and provided robust dose-response associations. FDA is recommended for use in normal tissue complication probability modeling
Continuous metadata flows for distributed multimedia
No full textThe practical use of temporal multimedia has increased markedly in recent years as enabling technologies for the distribution and streaming of media have become available. As a part of this trend, hypermedia systems and models have adapted accordingly to incorporate such distributed multimedia for presentation. Structured interpretation of information has long been a fundamental feature of both open hypermedia systems and knowledge systems. Metadata, in its many forms, has become the cornerstone for providing this structured knowledge above and beyond basic data and information. This thesis presents the rationale and requirements for continuous metadata, which supports the metadata accompanying distributed multimedia throughout the lifecycle of streamed media, from generation, through distribution, to presentation. Throughout this process it is the temporal and continuous nature of the metadata which is paramount. A conceptual framework for continuous metadata is proposed to encapsulate these principles and ideas. Continuous metadata and the associated framework enable the development, in particular, of real-time, collaborative, semantically enriched distributed multimedia applications. Experience building one such system using continuous metadata is evaluated within the framework. An ontology is developed for the system to enable the collation, distribution, and presentation of structure aiding navigation of multimedia, and it is shown how continuous metadata utilising the ontology can be distributed using multicas
097. Meet the Professor: Dr. Ryan Tinetti
No full textConcordia Seminary Dean of Theological Research and Publication Dr. Kevin Golden takes some time to introduce new faculty member Dr. Ryan Tinetti, who recently joined the Seminary as assistant professor of Practical Theology.
Tinetti previously served as pastor at Trinity Lutheran Church in Arcadia, Mich. (2018-24); Beautiful Savior Lutheran Church in Spokane, Wash. (2014-18); and Faith Lutheran Church in Seaside, Calif. (2010-14). He was a guest lecturer at Lutheran Theological Seminary in Praetoria, South Africa (2024), and Concordia Theological Seminary, Fort Wayne, Ind. (2024), and he is the author of the book “Preaching by Heart” (Cascade Press). Tinetti earned a Doctor of Ministry (D.Min.) (2019) from Duke University in Durham, N.C., and a Master of Divinity (M.Div.) (2010) from Concordia Seminary. In 2005, Tinetti received a Bachelor of Arts from Michigan State University in East Lansing, Mich. Learn more about Tinetti.https://scholar.csl.edu/cjc/1098/thumbnail.jp
Research on land markets in South Asia : what have we learned?
Get PDFThe authors review the literature on land markets in South Asia to clarify what's known and to highlight unresolved issues. They report that: (1) We have a good understanding of why sharecropping persists and why it can be superior to other standard agricultural contracts. We have less understanding of what determines the relative efficiency of sharecropping in different environments and why other apparently superior contractual relationships are rare. (2) Insecure rights to land adversely affect production and investment incentives in areas outside of South Asia, but in South Asia strong evidence linking investment and rights to production is scarce. (3) An inverse relationship between farm size and output per unit area is a recurrent feature in data from South Asia, apparently related to land-labor interactions. (4) Although small farms seem to be more efficient than large ones, small farmers have trouble raising their profitability and enlarging their holding, largely because of credit constraints, but also because of poverty and policy that discriminates against them. (5) Misguided land reform in the past has made tenancy unattractive to landowners, so large capital-intensive farms have developed. Political economic analysis is needed to explain the failure of past land reform, as well as distortions in agricultural input and output markets in (6) South Asia. Land fragmentation (as distinguished from farm size) has caused productivity losses. Those losses have not been quantified and the reasons fragmentation persists are poorly understood. (7) Transaction costs are a significant impediment to functioning land markets. In South Asia, transfers of land rights are complicated by lack of explicit title to land, and by informal and customary rights. (8) One pressing research problem is gender discrimination, an important factor in land market imperfections -especially (within the household) the separation of land management and its control. Research needs include more systematic regional comparisons, the use of more panel data, and an investigation of how agricultural productivity is affected by gender problems and land fragmentation.Banks&Banking Reform,Environmental Economics&Policies,Agricultural Knowledge&Information Systems,Land Use and Policies,Public Sector Economics&Finance,Environmental Economics&Policies,Banks&Banking Reform,Agricultural Knowledge&Information Systems,Rural Land Policies for Poverty Reduction,Land Use and Policies
Open Access Monographs - Current Initiatives and Progress on Sustainable Models for Making Monographs Openly Accessible (webinar screening)
No full textThe open access monograph is now definitely an important component of the scholarly communications landscape. However, with a growing number of initiatives, publishers, and economic models, the question is sustainability. There are a number of different models, including Open Book Publishers, Open Humanities Press, and numerous university and commercial publishers who have open monograph publications, thus more initiatives than we could include for this one-hour webinar. We have invited a selected number of representatives from various open monograph publishing initiatives to participate in a panel discussion about their current economic models and future of open access monographs. Each panelist will give a brief statement about their initiative, their editorial review process, their funding model, and their perspectives on the future of open access monographs. Following their brief statements, we will have a question and answer period moderated by Kevin Smith, the Dean of Libraries at the University of Kansas. We encourage academic libraries to invite members of their faculty to join in viewing the presentation and for the live presentation as questions from the audience will be addressed during the Q & A session. Participants for the panel include: AAUP Open Access Monograph Publishing Initiative - Wendy Pradt Lougee, University Librarian and McKnight Presidential Professor, University of Minnesota, Twin Cities. The Association of American Universities (AAU), Association of Research Libraries (ARL), and Association of American University Presses (AAUP) are implementing a new initiative with 13 universities and 60 university presses participating. Universities will provide subventions for open digital monographs, to be published by university presses. Lever Press and Knowledge Unlatched - Charles Watkinson, Associate University Librarian for Publishing, University of Michigan Library, and Director, University of Michigan Press. University of Michigan Press and Amherst Press are partners in the Lever Press which is supported by pledging institutions. University of Michigan Press has also been an active participant in Knowledge Unlatched, which uses a crowd -source funding model to make previously published works openly available. Charles is also a Board Member of Knowledge Unlatched Research and will compare Lever Press with KU. Luminos - Erich van Rijn, Assistant Director, Director of Publishing Operations at University of California Press. The financial model is shared costs between author, institution, publisher, and libraries. University of Ottawa Press - Lara Mainville, Director of University of Ottawa Press. OA publications are funded by the University of Ottawa libraries. Moderator: Kevin Smith, Dean of Libraries at the University of Kansas. Prior to joining the University of Kansas, Kevin served as Director of Copyright and Scholarly Communications at the Duke University Librarie
00-03 "Trade Liberalization and Pollution Intensive Industries in Developing Countries: A Partial Equilibrium Approach."
Get PDFEconomic theory suggests that liberalization of trade between countries with differing levels of environmental protection could lead pollution-intensive industry to concentrate in the nations where regulations are lax. This effect, often referred to as the "pollution haven" hypothesis, is much discussed in theory, but finds only ambiguous support in empirical research to date. Methodologies used for research on trade and environment differ widely; many are difficult to apply to practical policy questions. We develop a simple, partial equilibrium model explicitly designed to analyze the effects of a change in trade policy. Our model analyzes the relative concentrations of "clean" and "dirty" industries in two nations or regions, before and after the policy change. While lacking the theoretical rigor and mathematical intricacy of other modeling methods, our approach has the advantages of transparency and accessibility to a broad range of analysts and policy makers.
The Value of Time and the Transactions Demand for Money.
No full textThis paper reexamines the hypothesis of Dean S. Dutton and William P. Gramm, and Edi Karni that the wage rate influences the demand for money as a proxy for the value of transactions time. It develops "value of time" transactions models, which yield demand for money equations that have a real wage rate argument, and compares it to a "non value of time" alternative that does not. The author finds that the "value of time" models perform well and that the "value of time" effect is empirically significant. Copyright 1990 by Ohio State University Press.
Post-Foucauldian governmentality: what does it offer critical social policy analysis?
Get PDFThis article considers the theoretical perspective of post-Foucauldian governmentality, especially the insights and challenges it poses for applied researchers within the critical social policy tradition. The article firstly examines the analytical strengths of this approach to understanding power and rule in contemporary society, before moving on to consider its limitations for social policy. It concludes by arguing that these insights can be retained, and some of the weaknesses overcome, by adopting a ‘realist governmentality’ approach (Stenson 2005, 2008). This advocates combining traditional discursive analysis with more ethnographic methods in order to render visible the concrete activity of governing, and unravel the messiness, complexity and unintended consequences involved in the struggles around subjectivity
Lamellipodia as Proliferation Machines: How Branched Actin Based Feedback Loops Allow Melanoma to Evade Growth Inhibition
No full textThe general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.Spatial regulation of Rac1 activity is well-characterized and important for several cellular functions, including building and sustaining protrusive branched actin networks at the cell edge. High Rac1 activity sits atop a dense cytoskeletal scaffold that drives the extension of a flat lamellipodium, whose tightly packed volume forms a microdomain of enhanced signaling activity with elevated transduction efficiency. Cancer cells can coopt this mechanism to drive proliferation and survival signaling. For example, the hyperactive Rac1P29S mutation found in 10% of melanoma patients is associated with advanced disease, increased resistance to MAPK pathway inhibitors, and decreased patient survival. Previous work demonstrated that these clinical phenotypes correlate at a cellular level with sustained proliferation under drug challenge and is linked to a cell's ability to build extended lamellipodia. Using FRET- and localization-based biosensors for Rac1 activity, we observe larger and more potent microdomains in melanoma cells expressing Rac1P29S. The resultant branched actin network provides abundant binding sites for the tumor suppressor NF2/merlin. Superimposition of heightened Rac1 activity poises the Rac1 effector kinase PAK to inactivate merlin through phosphorylation. Displacement of merlin from the lamellipodia by a competitive actin-binding peptide interrupts this phospho-inactivation, re- sensitizing melanoma cells to MAPK inhibition. However, merlin plays an additional role upstream of the Rac1 signaling domain. Merlin recruitment to the cell edge limits protrusion formation. Knockout of merlin recapitulates the Rac1P29S-induced phenotype, producing enhanced lamellipodia with elevated wildtype Rac1 activity upon MAPK-inhibition. Breaking merlin's inhibition of the branched actin network similarly allows for enhanced lamellipodia formation, and ultimately merlin phospho-inactivation. Together these data support a double-negative feedback--Rac1 microdomains inactivate merlin localized to the dense branched-actin networks; active merlin, in turn, attenuates microdomain formation through inhibition of branched actin polymerization. This localized signaling feedback is thus prone, when perturbed, to produce self-sustaining patterns of signaling activity, allowing for MAPK-inhibited melanoma to escape merlin-mediated growth control
- …
