7 research outputs found
Polylithic Integration of SAW Devices using Quartz-on-Silicon Process for True Single Chip Radio
No full textThe author would like to thanks LG Innotek Company for the fabrication of high Q SAW resonator. This work is supported by MICROS (Micro Information and Communication Remote Object-oriented System) Research Center
Inference of time series regression models with weakly dependent errors
No full textIn this thesis we develop inferential methods for time series models with weakly dependent errors in the following three aspects. The first aspect concerns the issue of the size-distortion in the presence of strong temporal dependence, which is well-known in the literature. There are recently proposed bandwidth-free methods, which generally reduces the size-distortion compared to the traditional method. However, these methods still suffer from severe size distortion when the temporal dependence in the error process is strong. We propose to use the prewhitening to handle the strong temporal dependence so that the size distortion is greatly reduced in the presence of strong temporal dependence in the error. This work is presented as Chapter 2, in the context of time series regression with dynamic regressors and stationary and weakly dependent errors. The second and third aspects are motivated by the recent surge of awareness that the stationarity assumption for the error is often too restrictive for real data. Some macroeconomic series are often observed to have heteroscedastic behavior. In Chapter 3, we introduce short-memory nonstationary error framework that can accommodate a wide range of nonstationary linear processes or modulated stationary processes in the context of trend assessment setting. We propose a method that can handle both heteroscedastic behavior and the temporal dependence in the error process. In Chapter 4, we further introduce a piecewise locally stationary framework for the error process that can cover a wide range of linear and nonlinear processes that are short-memory nonstationary
in the unit root setting. A bootstrap-based method is proposed and its consistency is proved.Item withdrawn by Laura Spradlin ([email protected]) on 2014-07-10T19:26:22Z
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University of Illinois Theses & Dissertations (ID: 1)
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Public Management of Health Expenditures in Response to COVID‐19 and Traditional Infectious Diseases: The Korean Experience
No full textABSTRACT This study investigates the effectiveness, allocative efficiency, and crowding‐out effects of health expenditures in response to traditional infectious diseases and the COVID‐19 pandemic. Through theoretical analysis and empirical data from Korean local governments, employing a two‐way fixed effects model, we derive several key findings. First, social insurance health expenditures were significantly effective in controlling both traditional infectious diseases and COVID‐19, whereas general government health expenditures were not. Second, allocative efficiency, the principle of allocating more resources where needed, was not observed in the response to traditional infectious diseases but was significant in the COVID‐19 response. Third, we identified a crowding‐out effect where increased health expenditures for COVID‐19 reduced funds for traditional infectious disease responses. These findings offer strategic insights for Asia‐Pacific countries in optimising health resource allocation and budget management amidst evolving health crises
Intra-accumbens Microinfusion of the Dopamine D3 Receptor Partial Agonist (±)VK4-40 Does Not Affect Basal Locomotion in Mice
No full textThe opioid epidemic remains a pressing public health crisis, prompting the search for alternative pharmacotherapies for Opioid Use Disorder (OUD). This study explores the potential of the dopamine D3 receptor (D3R) partial agonist, (±)VK4-40, as a novel treatment option. We investigated the impact of intra-nucleus accumbens (NAc) microinfusion of VK4-40 on basal locomotion in mice. Results indicate that VK4-40 did not significantly alter basal locomotion, suggesting that its therapeutic effects may not be mediated through disruptions in generalized motor function. Future research will focus on elucidating the neuropharmacological mechanisms underlying VK4-40\u27s therapeutic actions and exploring its effects on psychostimulant-induced hyperlocomotion. These findings provide valuable insights into potential D3R-targeted pharmacotherapies for managing OUD
Author Correction: The Mobility Enhancement of Indium Gallium Zinc Oxide Transistors via Low-temperature Crystallization using a Tantalum Catalytic Layer
No full textA correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.</jats:p
Optimizing Preventive Care: The Impact of a Student-Led Initiative to Improve Cancer Screenings in Primary Care
No full textContext:
Preventative health measures, including routine cancer screenings, are essential for early detection, timely treatment, and reduction of cancer mortality rates.
Colorectal, breast, and cervical cancer are among the most routinely screened cancers due to advancements in screening technologies1. However, despite the well-established importance of early detection, patient adherence and compliance with national guidelines remain suboptimal, limiting the effectiveness of these screening efforts and delaying possible treatment.2
Objective:
To address this issue, we initiated a medical student-led project focused on improving adherence to national cancer screening guidelines across Rowan-Virtua Family Medicine (FM) practices. This poster outlines the overall efficacy of this project, including penetration rate into the patient population, closure of care gaps, and outcomes of screening and detection.
Methods:
The study is a prospective interventional cohort study. Rowan-Virtua Family Medicine patients between the ages of 21-80 (n=911) were identified between January 1, 2023 to February 1, 2025 as overdue on cancer screenings based on chart review. Participants were excluded (n=3) if they were deceased or were no longer patients of Rowan-Virtua FM. Student volunteers contacted patients to discuss options for overdue screenings and inform patients of current national cancer screening guidelines. Patients were given the option to make their screening appointment, obtain a referral from the clinic, or decline screening. Patient demographics including sex, age, race/ethnicity, and insurance type were collected. Outcomes included patient eligibility, number and rates of patients reached, up-to-date patients, referrals placed, completion rates for referrals, and abnormal screening findings occurrence.
Results:
Among the 908 patients included in this analysis, the average age was 60.96 (SD: 9.52), 74.01% were female, 63.33% were white, 15.75% were Black, 3.19% were Hispanic, 2.97% were Asian and 14.76% did not specify their race/ethnicity. Per chart review, 822 (90.53%) patients were identified as being due for at least one cancer screening. Of those patients, 386 (46.96%) patients reached via telephone, 28.5% received at least one referral for cancer screening, 13.73% reported being up-to-date on screenings, 19.17% reported they already had a referral and would make an appointment, and 38.6% declined screening. A total of 47 colonoscopy, 39 Cologuard® test, 48 mammogram, and 22 pap smear referrals were placed among 110 patients. 41.81% (46 out of 110) received referrals for more than one screening. Of the patients who received referrals, 54.55% of patients went on to receive at least one of their recommended screenings. The completion rates for referrals were as follows: 40.43% for colonoscopies, 41.03% for Cologuard, 56.25% for mammograms, and 45.45% for pap smears. Of the patients who completed their screenings, the rate of positive findings was as follows: 63.16% for colonoscopies, 18.75% for Cologuard, 33.33% for mammograms, and 0% for pap smears.
Conclusion: This project emphasizes the crucial role of primary care in promoting adherence to preventive health screening guidelines and highlights the importance of patient outreach in improving compliance. Notably, among the patients who completed their screenings, abnormal results were detected, necessitating further management or increased future surveillance. These findings underscore the critical role of routine screenings in early detection and intervention. Moving forward, continued efforts to educate patients on the importance of cancer screenings, increasing awareness of guidelines, and addressing barriers to screening access will be essential to further improve patient adherence and promote holistic care. This study also demonstrates the crucial impact that trained and engaged medical students can have in the closure of care gaps and improvement of preventive screening outcomes in the primary care setting
PROKR1 delivery by cell-derived vesicles restores the myogenic potential of Prokr1-deficient C2C12 myoblasts'''
No full textCell-derived vesicles (CDVs) have been investigated as an alternative to exosomes. Here, we generated CDVs from Prokineticin receptor 1 (PROKR1) overexpressing HEK293T cells using micro-extrusion. More than 60 billion PROKR1-enriched CDV (PROKR1(Tg) CDVs) particles with canonical exosome properties were recovered from 10(7) cells. With 25 mu g/mL of PROKR1(Tg) CDVs, we observed delivery of PROKR1, significant reduction of apoptosis, and myotube formation in C2C12(Prokr1-/-) myoblasts that have lost their myogenic potential but underwent apoptosis following myogenic commitment. Expression levels of early and late myogenic marker genes and glucose uptake capacity were restored to equivalent levels with wild-type control. Furthermore, PROKR1(Tg) CDVs were accumulated in soleus muscle comparable to the liver without significant differences. Therefore, CDVs obtained from genetically engineered cells appear to be an effective method of PROKR1 protein delivery and offer promise as an alternative therapy for muscular dystrophy. (C) 2021 The Author(s). Published by Elsevier Inc.Y
