2,311 research outputs found
[News Clip: Edith Deen]
No full textVideo footage from the WBAP-TV television station in Fort Worth, Texas, to accompany a news story about author, columnist, and lecturer Edith Alderman Deen receiving an honorary Doctor of Letters degree from Texas Women's University
Conversations with authors: Edith Pearlman
No full textA 2011 conversation with the author Edith Pearlman about her life and the inspiration for her work
Interview with Major Edith Vowell Part 2
No full textAnna Maria Island author included Major Edith Vowell in his book, Combat Nurses of World War II. Here she tells her story, with adventures in Brisbane, Australia, on ships and a GI troop train. She also lists her postwar nursing postings
Studies of genetic influences on nicotine dependence utilising functional neuroimaging
No full textA major contributor to relapse following smoking cessation is nicotine craving triggered by environmental cues, such as the sight of a lighted cigarette. Therefore, three integrated functional neuroimaging studies were conducted to examine the biological mechanisms underling cue-elicited craving for cigarettes.(1) First, I examined the effect of smoking-related pictorial cues on neural activation hi brain regions of interest (ROI) associated with reward signalling using functional magnetic resonance imaging (fMRI). Voxel-wise analysis demonstrated that smokers, but not nonsmokers, demonstrated significant activation associated with smoking-related pictorial cues in the anterior cingulate cortex, orbitofrontal cortex, and ventral striatum. Upon ROI analysis of the ventral striatum including the nucleus accumbens (VS/NAc), smokers exhibited significantly greater VS/NAc activation than non-smokers.(2) Next, I examined whether pre-specifled serotonergic polymorphisms would affect binding potential (BP) to a serotonin (5-HT) receptor implicated in the behavioural sensitisation process to nicotine (5-HTiA receptor). Healthy volunteers who had undergone positron emission tomography (PET) with a 5-HTiA-specific ligand [ U C]WAY-100635 were genotyped for the 5-HT1 A -1018 G>C and 5-HT transporter (5-HTT) 5-HTT gene-linked polymorphic region (5-HTTLPR) polymorphisms. Participants carrying the 5-HTTLPR S allele (SS or SL genotypes) demonstrated significantly lower global presynaptic and postsynaptic BP compared to subjects with LL genotypes.(3) Finally, I triangulated the two initial studies to examine whether pre-specified trait (5- HTTLPR genotype) and/or state (smoking vs. abstinence) variables would influence cueelicited activation of the VS/NAc. There was greater activation to smoking-related cues in the VS/NAc of smokers during the smoking condition than the abstinent condition and a significant correlation between tobacco craving and VS/NAc activation in the smoking condition. The 5-HTTLPR polymorphism was not associated with VS/NAc activation. Power calculations are presented as the basis for future examination of genetic hypotheses. These data have implications for the ultimate goal of enhancing the efficacy of smoking cessation pharmacotherapy
Bob Sim, Memories from Oxford and Grenoble
No full textI initially met Bob and Edith Sim when they moved to Grenoble in 1976 for a two-year fellowship at the Centre d’Etudes Nucléaires [...
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