784 research outputs found
Characterization of Ketoprofen/Methyl-β-Cyclodextrin Complexes Prepared Using Supercritical Carbon Dioxide
No full textComplexes of methyl-β-cyclodextrin and ketoprofen, a crystalline anti-inflammatory drug with poor water solubility, have been prepared for the first time in the presence of supercritical CO2 at 40°C and 20 MPa. The supercritical treatment allows these pharmaceutical formulations to be prepared without the use of any auxiliary agents or organic solvents. The treated samples were characterized through differential scanning calorimetry, X-ray diffractometry, and the Fourier transform infrared spectroscopy to exclude the presence of crystalline drug and check the formation of the complexes. The increase of the drug dissolution rate was investigated performing in vitro release tests in aqueous solutions. The results showed that the supercritical treatment can be an efficient method to obtain inclusion complexes with enhanced release kinetics. The operating methods of the release tests, that is, the “tablet method” or the “dispersed amount method,” affected both the dissolution rate and its dependence on the drug amount in the samples. On the contrary, the variation of the pH of the dissolution medium did not show any effect on the release rate of the supercritical complexes
Materiali nanocompositi intercalati e/o esfoliati ed argille organofile modificate, utili per la produzione di tali nanocompositi
No full textGene specific therapy for arrhythmogenic disorders.
No full textReview article summarizing our latest work in the field of gene specific therapy of inherited arrhythmogenic disease
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No full textCellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome Laura Bianchi, Zhijun Shen, Adrienne T. Dennis, Silvia G. Priori, Carlo Napolitano, Elena Ronchetti, Robert Bryskin, Peter J. Schwartz and Arthur M. Brown Human Molecular Genetics 8, 1499–1507 (1999) The authors would like to amend the order of the author list as follows: Laura Bianchi, Silvia G. Priori, Zhijun Shen, Adrienne T. Dennis, Carlo Napolitano, Elena Ronchetti, Robert Bryskin, Peter J. Schwartz and Arthur M. Brown. Silvia G. Priori and Zhijun Shen contributed equally to the work
Powder diffraction study of arsenic-substituted nasicon structures MeZr2As(3-x)PxO12 (Me = Na+, K+).
No full textThe impregnation of mesoporous silica with diaminohexane by means of supercritical CO2: A possible CO2 solid sorbent
No full textAmong solid sorbents, silica is particularly interesting thanks to its stability and versatility. With this in mind, we developed a silica sorbent impregnated with amino groups to increase its ability to capture CO2. A commercial mesoporous silica (type SBA-15) was impregnated with a diamine (diaminohexane) by using supercritical CO2 as a green solvent. The so obtained sorbent was physico-chemically characterized and its adsorption behavior was investigated by means of volumetric isotherms at room temperature (and data were fitted by Langmuir models) and in situ Fourier Infrared Spectroscopy. The results prove that the impregnation with supercritical CO2 is effective and the resulting material is able to capture CO2. Although the CO2 capture capacity value of the impregnated material is comparable to that of the pristine one (0.89 mmol/g and 0.94 mmol/g, respectively, at 25 °C), the impregnated sorbent is significantly more efficient in capturing CO2 at low pressure. Chemisorption and, secondary, physisorption are observed. Both phenomena are reversible at room temperature, allowing an easy regeneration of the sorbent. The material, moreover, is stable also at higher temperature, proving to be compatible with thermal regeneration processes. Finally, Langmuir modeling indicates a dual-site behavior, with stronger adsorptions sites attributed to amines, and weaker sites attributed to silica
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