100 research outputs found
Synthesis conjugation, and immunological evaluation of phosphonoester analogues of serogroup A Neisseria Meningitidis a capsular polysaccharide.
No full textSynthesis of di- and tri-saccharide fragments of Salmonella typhi Vi capsular polysaccharide and their zwitterionic analogues
No full textZwitterionic polysaccharides (ZPS) behave like traditional T cell-dependent antigens, suggesting the design of new classes of vaccines alternative to currently used glycoconjugates and based on the artificial introduction of a zwitterionic charge motif onto the carbohydrate structure of pathogen antigens. Here we report the new synthesis and antigenic evaluation of di-/tri-saccharide fragments of Salmonella typhi Vi polysaccharide, as well as of their corresponding zwitterionic analogues. Our strategy is based on versatile intermediates enabling chain elongation either by iterative single monomer attachment or by faster and more flexible approach using disaccharide donors. The effect of structural modifications of the synthetic compounds on antigenic properties was evaluated by competitive ELISA. All the oligosaccharides were recognized by specific anti-Vi polyclonal antibodies in a concentration-dependent manner, and the introduction of a zwitterionic motif into the synthetic molecules did not prevent the binding
A new fully synthetic analogo f type A Neisseria Meningitidis capsular polysaccharide is immunoactive
No full textSynthesis of fragments of Salmonella typhi capsular polysaccharide and their zwitterionic analogues
No full textA new fully synthetic analogo f type A Neisseria Meningitidis capsular polysaccharide is immunoactive.
No full textModulation of the biological function of a synthetic carbohydrate antigen related to Streptococcus pneumoniae infections.
No full textAlpha-galactosylceramide modulates the induction of indoleamine 2,3-dioxygenasein antigen presenting cells
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