1,720,980 research outputs found
Pregnancy and periodontal disease: Does exist a two-way relationship?
No full textPeriodontal disease (PD) is an inflammatory disease of the tissues supporting the teeth. PD affects 65 million adults over the age of 30 years in the USA, and worldwide 5 to 70% of adults. Women who develop PD during pregnancy, itâs estimated 1 woman in 5, may have a higher risk of adverse pregnancy outcomes. PD during pregnancy starts by dental plaque and is increased by the action of pregnancy hormones. In order to study the effect of PD on adverse pregnancy outcomes, we have performed this narrative review summarising the current studies about the influence of PD on pregnancy. Periodontal pockets are a reservoir of oral microbiota. Modifications in oral microbiota may be considered as a potential mechanism for developing PD during pregnancy. PD is surely caused by bacteria, but the progression and worsening are due to a host immune response. The inflammation caused by PD is not limited to the oral cavity. It is hypothesized that episodes of bacteraemia and dissemination of endotoxins from periodontal pockets can induce the activation of the systemic immune response. In conclusion our narrative review shows that thereâs no relationship between PD and adverse pregnancy outcomes, and PD treatment during pregnancy does not confer a general protection against adverse pregnancy outcomes
Delayed expansion of atrophic mandible (deam): a case report
Full text linkThe present case report presents the clinical results of delayed expansion of mandibles by ultrasonic surgery in case of mono edentulous. The patients with a residual alveolar ridge thickness between 2,3 and 4,1 mm in the coronal area of posterior mandible was threated. In the first stage, four linear corticotomies were carried out by ultrasonic surgical device; bone expansion was not performed. After 4 weeks, in the second stage, adequate bone expansion, without compromising cortical vascularisation, by utilising a combination of scalpel, thin chisels and threaded osteotomes was achieved and one implant was placement, after filling the gaps with a cortico bovine biomaterial. The postoperative course was uneventful and final width ridge was 6,17±0,26mm. The present case report showed that mandibular ridge expansion using a delayed split-crest technique by means of ultrasonic surgery and association with biomaterial clinically lead to a good horizontal bone gain with no fractures of the buccal plate and high implant success rate
Salivary flow and xerostomia in patients with type 2 diabetes
No full textSaliva is secreted by the major and minor salivary glands. There are a number of physiological factors that can reduce this secretion such as age, sex, body weight, number of teeth present in the mouth or time of day. This decrease may also be caused by the use of certain drugs, radiotherapy for head and neck cancer, chronic rheumatic diseases such as Sjögren's syndrome and other systemic disorders such as diabetes mellitus (DM). Objective of this study was to investigate the effect of type 2 DM on salivary secretion and its relation to the sensation of xerostomia
Immediate loading implants: Review of the critical aspects
No full textPurpose. Modern dentistry have witnessed, a rapid and continuing evolution. Concerning the implant-rehabilitation protocols, they have beenEdizioniredefined in order to satisfy patientâs increasing expectations in terms of comfort, aesthetic and shorter treatment period. The purpose of this review is to explore the concept of implant immediate loading and the indications for clinical practice. All the critical aspects that could influence the outcomes of this treatment will also be considered. Materials and methods. Three protocols for implant load timing have been classified: immediate loading implants (ILI); early loading implants (ELI); and conventional loading implants (CLI). Two subclassifications point out the different loading modality: 1) Occlusal loading or Non-Occlusal loading, 2) Direct loading or Progressive loading. Mi-cromovements have been considered, since the start of implant dentistry, one of the main risk for the success of osseointegration. The determinant and most accessible parameter to assess the primary stability is the implant insertion torque value. To achieve the necessary torque value to perform immediate loading, it is therefore important to evaluate the bone density at the implant site. Computerized tomography (CT) has been regarded as the best radiographic method to evaluate the residual bone. Results. The clinical success of this technique is highly dependent on many factors: patient selection, bone quality and quantity, implant number and design, implant primary stability, occlusal loading and clinicianâs surgical ability. Among these, implant primary stability is undoubtedly the most important. Conclusion. Studies on ILI show that successful outcome can be expected, if the previous criteria are fulfilled. It seems that ILI demonstrate a greater risk for implant failure when compared to CLI, although the survival rates were high for both the procedures. The use of different surgical procedures, type of prostheses, loading times and have very different study designs. This lack of homogeneity limits the relevance of the conclusions that can be drawn
Neuroinflammation, Alzheimer's disease and periodontal disease: is there an association between the two processes?
No full textAlzheimers disease (AD) is a very common cause of dementia in developed countries and increases its prevalence progressively with age. AD etiopathogenesis is not yet understood. However, it is recognized that neuroinflammation plays a key role in its pathogenesis with the activation of microglia and the secretion of proinflammatory cytokines triggering irreversible neurodegenerative deterioration. This paper is a short review of the relationship between AD and periodontal disease (PD). Both processes may have common causes: both are inflammatory diseases and the prevalence and progression increases with ageing. However, we must consider that AD begins to develop many years before its clinical diagnosis. It is thought that in this prodromal period a connection could be established between both processes, both sustained by low intensity inflammation. There are several studies that relate both processes such as the possible systemic exposure to certain periodontopathogenic bacteria or the proinflammatory cytokines and other elements. It is argued that there are no modifiable factors such as age, or genetic factors, but that there are other factors that could be avoided, modified or controlled such as periodontal peripheral inflammation
Cleft palate only: Current concepts
No full textCleft palate only (CPO) is one of the most common congenital malformations worldwide. The etiopathogenesis of CPO is not completely understood. Environmental factors, such as smoking, alcohol consumption, intake of drugs during pregnancy, advanced paternal age, have been demonstrated to be a risk of CPO, but conflicting results have also been published. Insufficient intake of folic acid during the pregnancy has been suggested to increase the risk for CPO. The demonstrated risk for siblings and the higher risk for monozygotic twins suggest a genetic etiopathogenesis for CPO. In some cases of CPO a prevalent mode of inheritance has been reported, but oligogenic models with reduced penetrance, and the risk related to environmental factors have also been proved. One of the first manifestations associated with CPO is difficulty with feeding. Aerophagia is a problem in these infants with CPO and requires more frequent burping and slower feeding. The inability to generate intraoral breath pressure due to nasal air emission in CPO children frequently manifests as articulation difficulties, particularly consonant weakness, and unintelligible speech. Hearing disorders are prevalent among individuals with CPO, as a result of chronic otitis media with effusion due to eustachian tube dysfunction. A multidisciplinary team is essential to manage the many aspects of CPO. In treating CPO, the reconstructive surgeon works in cooperation with otolaryngologists, dentists and orthodontists, speech pathologists, audiologists, geneticists, psychiatrists, maxillofacial surgeons, social workers, and prosthodontists. CPO can be considered a genetically complex disease, but new knowledge and new therapeutic approaches have greatly improved the quality of life of these children. Prenatal diagnosis is an important step in the treatment of this disease
Post extractive implant: Evaluation of the critical aspects
No full textPurpose. Nowadays, implant supported prosthetic rehabilitation is a reliable procedure to replace compromised or un-treatable teeth. The purpose of this review is to explore the concept of post extractive implant and the indications for clinical practice through an analysis of recent studies in the literature. All the main factors that could influence the outcome of this treatment will also be considered. Materials and methods. Focusing on the extraction-socket healing time, three different implant insertion protocols have been defined: Immediate implant placement (IIP), Early implant placement (EIP), Delayed implant placement (DIP). The entity of bone remodeling can be associated with different factors: three dimensional implant position, presence/absence of platform switching, absence of facial bony wall, inter implant/tooth distance. Results. All the studies in literature agreed that implant primary stability is the main condition for a successful osseointegration of dental implants. Primary implant stability is influenced by many factors including local bone quality and quantity, implant macro-design, soft tissue conditions and rehabilitation, surgical technique, prosthetic load timing, oral hygiene. Conclusions. There is insufficient evidence in literature to determine possible advantages or disadvantages of IIP, EIP or DIP. Studies suggest that IIP and EIP may be at higher risks of implant failures and complications than delayed implants; on the other hand the aesthetic outcome might be better when placing implants just after teeth extraction
A new implant-abutment connection for bacterial microleakage prevention: An in vitro study
No full textPurpose. The aim of our study is to evaluate the ability of a new type of implant (Konus Implant System®, Industrie biomediche e farmaceutiche, Italy) to isolate the internal of an implant-abutment connection from the external environment. Materials and methods. To identify the capability of the implant to protect the internal space from the external environment, the passage of genetically modified Escherichia coli across implant-abutment interface was evaluated. Implants were immerged in a bacterial culture for twenty-four hours and then bacteria amount was measured inside implant-abutment interface with Real-time PCR. Results. Bacteria were detected inside all studied implants, with a median percentage of 18% for Porphiromonas Gingivalis and 19% for Tannerella Forsythia. Conclusion. The reported results are similar to previous work. Konus Implant System® showed bacterial leakage similar respect others implant systems (18% Porphiromonas Gingivalis, 19% Tannerella Forsitya versus 20% of Bicon© and Anky-los® systems). In spite of the limits of our study, none two-piece implant system has been demonstrated to perfectly close the gap between implant and abutment
Periodontitis and cerebrovascular disease: A new novel in medicine
No full textThe aim of this review is to determine if there is a relationship between periodontal disease and
stroke. The included case-control and cohort studies mediate the incidence of stroke and periodontal
disease by analyzing different parameters. A literature review was carried out in PubMed, Scopus and
Embase databases using the key word “stroke” AND “periodontal disease”. An amount of 932 articles
came out from our research on these three databases. These articles were selected according to PRISMA
criteria. The following inclusion criteria were established: studies conducted in humans, articles
published in English and published in the last ten years. Exclusion criteria were: experimental studies
on animals, articles published more than 10 years ago, non-English language articles, articles of nonindexed
journals, and articles not directly related to the association between stroke and periodontitis.
These criteria reduced the number of articles from 932 to 399. At the end, articles that appeared to be
repeated in different databases have been eliminated: 254 articles remained. All these articles titles
were reviewed by the authors, who decided whether or not to include them in the review. We selected
an amount of 43 articles. These studies were reviewed by reading the titles and abstracts, and by finally
selecting the ones with the same topic of this review. When titles or abstracts were not clear, the complete
article was read. At the end 7 articles were selected. In addition, 2 systematic reviews and 1 article, cited
in the discussion, and regarding the protocol used in patients suffering from cardiovascular diseases and
periodontitis, were selected. The quality of these articles was evaluated through the JADAD system. In
conclusion, patients with stroke have a higher prevalence of periodontitis
Human β2-defensin in oral lichen planus expresses the degree of inflammation
No full textIn this work, it was decided to study the role of HBD-2, an inducible and not constitutionally expressed defensin, in the pathogenesis of Oral Lichen Planus (OLP) and of Burning Mouth Syndrome (BMS). Seventeen OLP patients, with a positive histopathologic diagnosis of the disease, were recruited into this study in order to measure the relative quantity of HBD-2 in their saliva and crevicular fluid. The values were compared with those collected from a group of 9 patients affected by the Burning Mouth Syndrome (BMS) and with a control group (CTRL) of 9 patients. There was no statistically significant difference between the groups (p=0.523; p=0.897). However, patients affected by OLP showed a dycotomic distribution of values: While 10 of them showed similar values to those found out in the other two groups, 7 patients expressed high levels of HBD-2, and 3500 pg/ml was the threshold to distinguish the subgroups. During the dental visit the clinician classified OLP patients into two groups according to the clinical presentation of the disease: Reticular and hyperplastic (white OLP), atrophic and erosive forms (red OLP). There was a statistical significant correlation between the clinical and numeric classification of the patients (p=0.004; p=0.001), and the expression of HBD-2 was higher in the red OLP group than in the white OLP group (p=0.000; p=0.000). In conclusion, this study shows that HBD-2 represents an index to assess active inflammation and it is probably linked to the presence of the typical band-like CD8+ infiltrate in Oral Lichen Planus
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