5,639 research outputs found
Boulton and Fothergill silver.
No full textPhDThis thesis is about the silver business of Matthew Boulton and John
Fothergill at their Soho Manufactory near Birmingham. Their
partnership lasted from 1762 until 1782.
A rounded discussion of the topic is attempted. Within the contexts
of industry elsewhere and Soho's other activities, successive chapters
cover the early development, marketing, production, design, and later
decline of the partners' silver.
Silver plate was prestigious and, untypically for Boulton, he
concentrated on sales to the public rather than trade customers. To
attract orders he made modest charges. This was viable where mainly
machinery was used to make plate, even though sales were not high,
since the expense of machinery was substantially covered by the larger
sales of non-silver items. However, where Boulton relied to a
greater degree upon hand methods, he lacked technical means to
compensate for low profit-margins. Moreover, inefficiency and the
firm's lack of capital which led to substantial bankers' interest
charges on payment for bullion, particularly when customers paid late,
caused losses. These problems applied particularly to silver plate
and were mainly responsible for the decision to reduce production
drastically; however, the manufacture of a large range of small items
remained relatively consistent.
The thesis includes appendices. Some contain new information about
annual totals for the following aspects of the business: the volume of
assay silver; each type of article; pieces sold on commission; and
sterling silver supplies. Other appendices provide details about the
partners' silversmiths and extracts from a Soho inventory.
This thesis involves a more detailed use of sources than previous
studies of the topic. Apart from the silver itself (which is
selectively illustrated), the Matthew Boulton Papers and statistics
derived from The Birmingham Assay office provide the main sources.
Manuscripts covering silver production elsewhere provide contextual
material for understanding the partners' silver business
Silver Springs
No full textSilver Springs, FL. The largest flowing springs in the world, over 750 million gallon daily. There are electric driven glass bottom boats where you can see to the greatest depth of 80 feet. Water temperature is 72 degrees both winter and summer. The spring is shown from sunrise to sunset, in all weather, every day of the year
Does inhibiting Sur1 complement rtPA in cerebral ischemia?
No full textHemorrhagic transformation (HT) associated with recombinant tissue plasminogen activator (rt-PA) complicates and limits its use in stroke. Here, we provide a focused review on the involvement of matrix metalloproteinase 9 (MMP-9) in rt-PA-associated HT in cerebral ischemia, and we review emerging evidence that the selective inhibitor of the sulfonylurea receptor 1 (Sur1), glibenclamide (U.S. adopted name, glyburide), may provide protection against rt-PA-associated HT in cerebral ischemia. Glyburide inhibits activation of MMP-9, ameliorates edema formation, swelling, and symptomatic hemorrhagic transformation, and improves preclinical outcomes in several clinically relevant models of stroke, both without and with rt-PA treatment. A retrospective clinical study comparing outcomes in diabetic patients with stroke treated with rt-PA showed that those who were previously on and were maintained on a sulfonylurea fared significantly better than those whose diabetes was managed without sulfonylureas. Inhibition of Sur1 with injectable glyburide holds promise for ameliorating rt-PA-associated HT in stroke
Sun Plaza Motel sign Silver Springs, FL
No full textSun Plaza Motel sign located in Silver Springs, Florida. Built in 1950, it is at 5461 East Silver Springs Boulevard.https://digitalcommons.unf.edu/historical_architecture_main/6273/thumbnail.jp
Analysis of unspliced (FL) and singly spliced mRNAs in wt and mutant HIV-1 particles
No full text<p><b>Copyright information:</b></p><p>Taken from "HIV controls the selective packaging of genomic, spliced viral and cellular RNAs into virions through different mechanisms"</p><p></p><p>Nucleic Acids Research 2007;35(8):2695-2704.</p><p>Published online 10 Apr 2007</p><p>PMCID:PMC1885669.</p><p>© 2007 The Author(s)</p> Singly spliced () and FL () RNAs were detected in RNA samples extracted from wt (lanes 1 and 4), ΔSL1SL3 (lanes 2 and 5) and mock (lanes 3 and 6) transfected cells and in corresponding viral particles (lanes 4–6) using standard RT-PCR. As a control, amplification was also performed using pNL4.3 plasmid as a template (lane 8). Bands corresponding to vif-2, vpr-3 and env-1 mRNAs are indicated by arrows. In the mutant virus, all amplicons were shortened by 34 nt, due to the SL1 deletion. This result is representative of at least three independent experiments
Surface ligand controls silver ion release of nanosilver and its antibacterial activity against Escherichia coli
No full textYan-Min Long,1,2 Li-Gang Hu,1,3 Xue-Ting Yan,1,3 Xing-Chen Zhao,1,3 Qun-Fang Zhou,1,3 Yong Cai,2,4 Gui-Bin Jiang1,3 1State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Beijing, China; 2Institute of Environment and Health, Jianghan University, Wuhan, Hubei, China; 3College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, China; 4Department of Chemistry and Biochemistry, Southeast Environmental Research Center, Florida International University, Miami, FL, USA Abstract: Understanding the mechanism of nanosilver-dependent antibacterial activity against microorganisms helps optimize the design and usage of the related nanomaterials. In this study, we prepared four kinds of 10 nm-sized silver nanoparticles (AgNPs) with dictated surface chemistry by capping different ligands, including citrate, mercaptopropionic acid, mercaptohexanoic acid, and mercaptopropionic sulfonic acid. Their surface-dependent chemistry and antibacterial activities were investigated. Owing to the weak bond to surface Ag, short carbon chain, and low silver ion attraction, citrate-coated AgNPs caused the highest silver ion release and the strongest antibacterial activity against Escherichia coli, when compared to the other tested AgNPs. The study on the underlying antibacterial mechanisms indicated that cellular membrane uptake of Ag, NAD+/NADH ratio increase, and intracellular reactive oxygen species (ROS) generation were significantly induced in both AgNP and silver ion exposure groups. The released silver ions from AgNPs inside cells through a Trojan-horse-type mechanism were suggested to interact with respiratory chain proteins on the membrane, interrupt intracellular O2 reduction, and induce ROS production. The further oxidative damages of lipid peroxidation and membrane breakdown caused the lethal effect on E. coli. Altogether, this study demonstrated that AgNPs exerted antibacterial activity through the release of silver ions and the subsequent induction of intracellular ROS generation by interacting with the cell membrane. The findings are helpful in guiding the controllable synthesis through the regulation of surface coating for medical care purpose. Keywords: silver nanoparticles, surface chemistry, silver ion release, Trojan-horse-type mechanism, respiratory chain, oxidative stres
Silver Princess Motel neon sign Ocala, FL
No full textSilver Princess Motel neon sign located in Ocala, Florida. It is at 3041 South Pine Avenue.https://digitalcommons.unf.edu/historical_architecture_main/6259/thumbnail.jp
Post Office (34488) Silver Springs, FL
No full textUnired States Post Office located in Silver Springs, Florida. It is at 3050 Northeast 55th Avenue.https://digitalcommons.unf.edu/historical_architecture_main/4878/thumbnail.jp
Silver Springs Visitor Survey: Season 1 (August 84)
No full textThis is a study of visitors to Silver Springs, FL, in August 1984
Silver Springs Visitor Survey: Season 2 (September 84)
No full textThis is a study of visitors to Silver Springs, FL, in September, 1984
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