3,694 research outputs found

    Episode 35: Alexis Castellanos, Author of “Isla to Island”, and Her Panel Presentation during the Operación Pedro Pan Two-Day Event

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    In Part 1 of “Operación Pedro Pan: The Voices and Stories of Cuba’s Child Exodus—A Knights HistoryCast Mini-Series,” the Department of History’s Sebastian Garcia talked with Alexis Castellanos, an author, illustrator, graphic novelist, and a panelist at the esteemed, conspicuous, and powerful “Operación Pedro Pan: Honoring the Cultural, Historical Legacy of Cuba’s Child Exodus” Two-Day Program that Florida Humanities, UCF’s Department of English and Department of Modern Languages and Literatures sponsored (see https://cah.ucf.edu/pedro-pan/ for more details on sponsors and the program in general). Sebastian structured this specific episode on Alexis Castellanos’ Isla to Island, a wordless graphic novel grounded by her personal family history and the history of Operación Pedro Pan (Operation Peter Pan). By analyzing such a historic event through the medium of fiction, Sebastian argued that this is one of the most unique Knights HistoryCast episodes of all time. Naturally, their conversation expanded to what she talked about during her panel presentation in Panel One, Day 1 of the event that featured “internationally renowned scholars that discussed the political, historical, and cultural legacy of Operación Pedro Pan (1960-1962).” (https://cah.ucf.edu/pedro-pan/) To purchase Isla to Island (strongly recommend), check out: https://islatoisland.com/. To find out more about Alexis and her professional work, check out her website at https://alexiscastellanos.com/https://stars.library.ucf.edu/knightshistorycast/1034/thumbnail.jp

    Concentration-dependent effects of the esterase inhibitor BNPP on macrophage migration and myelin phagocytosis

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    Wallerian degeneration of a peripheral nerve is mainly characterized by axon and myelin degradation and is paralleled by a massive invasion of peripheral macrophages into the nerve. These cells enter the nerve attracted by a cascade of chemokines and cytokines but require proteolytic and enzymatic factors which enables them to cross the blood-nerve barrier. Here we investigated whether U-naphthyl (alpha -NA) esterases - which have been shown to be exclusively expressed in human monocytes - play a role during Wallerian degeneration. These enzymes were blocked by the specific inhibitor bis(4-nitrophenyl)-phosphate (BNPP) in an established in vitro model of Wallerian degeneration. Sciatic nerve segments of mice were co-cultured with peritoneal macrophages and BNPP was added to the cultures in various concentrations and at different timepoints. The macrophage numbers and myelin density in the nerve segments and the myelin load of macrophages were evaluated. After BNPP treatment the macrophage number within the nerve was significantly diminished and the myelin load within the macrophages was decreased, resulting in elevated levels of preserved myelin within the nerves. These experiments clearly showed a double effect of the UNA esterase inhibitor BNPP on macrophages, First, it suggests a role for UNA esterases on the migratory potential of macrophages since their invasion into the nerves was diminished. Second, the reduced myelin uptake is due to the inhibition of phagocytic capacity of these cells by BNPP. The therapeutical use of this inhibitor for treatment of autoimmune diseases such as multiple sclerosis or Guillain-Barre syndrome remains to be investigated. (C) 2001 Elsevier Science B.V. All rights reserved

    "Cronica der Turckey" Sebastian Franck's Translation of the "Tractatus de Moribus, Condicionibus et Nequitia Turcorum" by Georgius de Hungaria

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    The Tractatus de moribus, condicionibus et nequitia Turcorum is one of the most important first-hand accounts of life in fifteenth-century Turkey known to modern scholarship. It is the work of a Christian former slave of the Turks, writing after his return to the West. Although the author does not name himself, he can be identified as a Dominican priest, Georgius de Hungaria, who died in Rome in 1502. His Tractatus is conceived as a work of anti-Islamic polemic, yet it contains a surprisingly unbiased appraisal of Turkish customs. First printed c.1480 when European apprehension in the face of Ottoman expansion was at its height, the Tractatus was reprinted in numerous editions, and was widely used as a source by other authors. Luther edited the text in 1530, using the positive account of Turkish customs and religious observance as a weapon in his polemic against the Roman Catholic Church: if heathens could perform such exemplary works, who could fail to doubt the efficacy of works as a means of salvation? Sebastian Franck in his German translation of the Tractatus went further: replacing Georgius' commentary with his own, he used the text to attack institutional religion as a whole and to promote his concept of a non-dogmatic, spiritual Church of individuals united with each other only through their union with God -a Church which was not closed to Moslems or members of any other creed. This translation or adaptation, the Cronica der Türckey, marks Franck's decisive break with the Lutheran cause and the beginning of his lonely path as a 'spiritual individualist'. Franck reworked his translation of the Tractatus for his major geographical work, the Weltbuch of 1534. This thesis concerns itself primarily with Franck's Cronica, providing the first modern critical edition of this text, in a near-diplomatic transcription with an extensive glossary. The thesis also includes transcriptions of the Tractatus; of Türckei, an anonymous translation of the Tractatus, and of relevant additional material from Franck's Weltbuch. None of these texts has been published in full in a modern edition. In the Introduction Franck's Cronica is compared in detail with the Tractatus, highlighting the changes that occur in translation; the character and the significance of these changes are then discussed. It is established that Franck, whilst being unwilling to reverse any of Georgius' value judgements on Islam and Turkish culture, is highly selective in his choice of material for translation, and frequently gives the text new nuances and adds his own comment. The question of the Tractatus' influence on Franck's further development as a writer and thinker is also raised. The investigation then turns to Franck's use of the Tractatus material in his Weltbuch. His eclecticism becomes apparent in this text, in which Georgius' account is juxtaposed - but not synthesised - with material from other sources, often of lesser veracity and greater anti-Islamic bias. Franck's distortion of the Tractatus material to suit his own line of argument is clearly discernible: from the unique phenomenon presented in the Tractatus the Turks become one more example of the general human tendency to externalise and dogmatise faith. In addition, the transmission of Cronica and Türckei is examined, and the relationship between these two translations is clarified: Franck certainly used Türckei in writing his Cronica, but is unlikely to be the author of the anonymous work

    Towards mapping the extent of irrigation in the last century : time series of irrigated area per country

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    A data set of annual values of area equipped for irrigation for all 236 countries in the world during the time period 1900 - 2003 was generated. The basis for this data product was information available through various online data bases and from other published materials. The complete time series were then constructed around the reported data applying six statistical methods. The methods are discussed in terms of reliability and data uncertainties. The total area equipped for irrigation in the world in 1900 was 53.2 million hectares. Irrigation was mainly practiced in all the arid regions of the globe and in paddy rice areas of South and East Asia. In some temperate countries in Western Europe irrigation was practiced widely on pastures and meadows. The time series suggest a modest rate of increase of irrigated areas in the first half of the 20th century followed by a more dynamic development in the second half. The turn of the century is characterized by an overall consolidating trend resulting at a total of 285.8 million hectares in 2003. The major contributing countries have changed little throughout the century. This data product is regarded as a preliminary result toward an ongoing effort to develop a detailed data set and map of areas equipped for irrigation in the world over the 20th century using sub-national statistics and historical irrigation maps

    Essays on Industrial Organization and Health Economics

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    This dissertation consists of three essays examining the nature of pricing in the pharmaceutical industry and the behavior of physicians prescribing drugs. I use a combination of structural modeling and reduced-form econometric techniques to illuminate how factors such as bargaining, competition, and network membership can affect prices and prescribing behavior. Ultimately, these insights can be used to influence public policy goals such as reducing prescription drug costs for patients or limiting unnecessary prescribing.In Chapter One, which is joint work with Sebastian Linde and Ralph Siebert, I focus on the determinants and effects of bargaining power on wholesale pharmaceutical drug prices. We estimate a structural bargaining model and find that large differences in bargaining power explain drug price heterogeneities across buyers, drug classes, and time periods. Our results show that transaction-specific determinants between buyers and sellers (such as transaction volume, buyer’s loyalty, multiple drug purchases from the same seller, etc.) exert strong effects on buyer bargaining power and drug prices. Our counterfactuals show that group purchasing organizations achieve price reductions that vary across drug classes and that these price reductions primarily depend on buyer price sensitivity.In the second chapter, joint with Günter Hitsch, Sebastian Linde, and Ralph Siebert, I turn to the retail prescription drug market. Here, we show that there is a significant amount of price variation for prescription drugs in the retail pharmaceutical market. Both negotiated prices (price between retail pharmacies and third-party insurers) and out of pocket prices (prices between retail pharmacies and insured patients) for a drug exhibit a high degree of price variation even when controlling for drug manufacturer, geographic location, pharmacy chain, etc. Furthermore, the nature of this price variation changes depending on if a drug is branded or generic.In the third chapter, joint with Svetlana Beilfuss and Sebastian Linde, I examine the problem of antimicrobial resistance and how physician membership in Accountable Care Organizations (ACOs) can influence antibiotic prescribing behavior. We use a two-part structural model that accounts for selection into treatment (the ACO group), and non-treatment (control group). We then compare physician antibiotic prescribing across these groups with adjustment for volume, patient, physician, and institutional characteristics. We find that ACO affiliation reduces antibiotic prescribing by about 23% per year. Furthermore, we show that failure to account for selection into treatment results in an understating of the average treatment effect

    2. A Human Being to Be Remembered | The 2024 UCF VLP Podcast Series

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    In Episode Two, Andrew Carroll’s herculean efforts to seek and collect over 210,000 war letters—that span since the American Revolution—demonstrate how others are as seriously committed to preserving the legacies of the men and women who served and fought for their country. Andrew shares several letters from his impressive collection, allowing us to be as close as possible to the Veterans—engaging with their own words, thoughts, and emotions. Indeed, themes central to UCF VLP are often exemplified in the 210,000 war letters Andrew has preserved for over twenty-five years. Andrew Carroll is an award-winning historian and author and is the founder and director of the Center for American War Letters at Chapman University. Andrew was the second keynote speaker invited to share his extraordinary work during the 2024 UCF VLP Institute. This episode was directed, produced, written, edited, and hosted by Sebastian Garcia and featured Andrew Carroll. Executive Producers: Sebastian Garcia and Dr. Amelia Lyons. Music: “Honor and Glory” and “Real Heroes” by SergePavkinMusic (Pixabay) Podcast Cover Artwork: Sebastian Garcia The 2024 UCF VLP Podcast Series is brought to you by the UCF History Department Podcast Network and UCF’s Veterans Legacy Program—a partnership with the U.S. Department of Veterans Affairs’ National Cemetery Administration.https://stars.library.ucf.edu/knightshistorycast/1051/thumbnail.jp

    Wang Tao’s Diary: excerpts Translated by Sebastian Eicher

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    In a little regarded episode from Wang Tao’s diaries, the author tells us about a two-week long journey from Shanghai to Hangzhou and to the West Lake. Wang Tao undertook this journey together with the missionary Griffith John, who at that time was trying to find ways to preach the gospel outside the treaty port of Shanghai. We know the rough outline of this journey from Griffith John’s writings, as it was the second half of a longer journey along the Grand Canal. But Wang Tao’s presence and his notes on it have so far been neglected. This is a loss, as the diary Wang Tao kept offers not only a personal and lively account of the journey, it also gives us some insight in the Chinese perception of the missionaries’ activities and a description of the Hangzhou era before the Taiping would ravage it only a bit more than a year later

    Episode 31: Professor Paul W. Wehr Day at the Pioneer Days Pine Castle Historical Society History Tent Event

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    The Department of History’s Sebastian Garcia talked with Mr. Richard Lee Cronin, author, historian, and event coordinator of the Pine Castle Historical Society HISTORY TENT, at the Annual Pine Castle Pioneer Days Event. This episode is dedicated to and is in honor of Professor Paul W. Wehr. A Professor of History at UCF since the Department’s inception in 1969, Professor Wehr retired in 1995 after 25 years of teaching his passion for history—inspiring countless students and faculty. Professor Wehr devoted much of his time to documenting the history of Orange County, specifically Pine Castle. This naturally led to a close relationship with the Pine Castle Historical Society, which dedicated Day 1 of the 2-day event at Pioneer Days to Professor Wehr for the first time this year. Sebastian decided to pay tribute to one of UCF’s original history professors by going to the Pine Castle Pioneer Days HISTORY TENT event dedicated to him and produced a podcast on location with Mr. Richard Lee Cronin, who knew Professor Wehr personally. Below are links to an Orlando Memory interview featuring Professor Wehr himself that Sebastian mentioned in the introduction of this podcast, the page to know more about his books and association with Pine Castle, and a UCF CAH article written about Professor Wehr shortly after his passing in 2021. https://orlandomemory.info/topics/oral-history-interview-with-dr-paul-w-wehr/ https://www.pinecastlehistory.org/publications-books-pamphlets/ https://news.cah.ucf.edu/news/remembering-paul-w-wehr/https://stars.library.ucf.edu/knightshistorycast/1030/thumbnail.jp

    Legalizing recreational marijuana: comparing ballot outcomes in four states

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    Medical marijuana is now available in 23 states, and its growing acceptance has paved the way for the legalization of recreational marijuana. This article examines four recent campaigns to legalize recreational marijuana–two failures and two successes. Using data from newspaper sources, interviews with key players, and other sources, we examine the factors that influence whether a ballot initiative succeeds or fails. We identify similarities and differences between the four measures, the social forces shaping the debate, their claims and counterclaims, and a set of factors that appear to increase the odds that a recreational marijuana ballot measure will be successful.Peer reviewe
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