1,720,993 research outputs found
Protocol of outcome evaluation for surgical release of carpal tunnel syndrome
No full textOBJECTIVE:
To propose and apply a protocol for assessing the outcome of surgery for carpal tunnel syndrome.
METHODS:
The protocol included a patient questionnaire that was self-administered before and 1 and 6 months after the operation to assess severity of symptoms (Boston questionnaire) and staging according to clinical (Giannini) and electrophysiological (Padua) severity scales.
RESULTS:
The results of a prospective series of 323 hands undergoing surgery for carpal tunnel syndrome by the mini-incision of the palm technique are reported.
CONCLUSION:
The method was found to be valid, precise, reliable, and straightforward, enabling a comparison of the results from different patient series and different operating techniques
Neuromyotonia as paraneoplastic manifestation of bladder carcinoma
No full textNeuromyotonia(NMT) or Isaacs syndrome is a rare syndrome characterized by continuous spontaneous muscle fiber contraction resulting from hyperexcitability of peripheral nerves often associated with autoimmune disorders and tumours. Here we report an unpublished association of NMT and bladder canc
Clinical Findings and Electrodiagnostic Testing in Ulnar Neuropathy at the Elbow and Differences According to Site and Type of Nerve Damage
No full textObjective The aim of the study was to evaluate the clinical and electrodiagnostic testing in ulnar neuropathy at the elbow and differences according to site (humeroulnar arcade vs. retroepicondylar groove) and injury physiopathology (axonal vs. demyelinating), through prospective multicenter case-control study. Design Cases and controls were matched by age and sex. Ulnar neuropathy at the elbow diagnosis was made on symptoms. Statistical analysis was performed using Mann-Whitney, χ2, and analysis of variance tests. Results One hundred forty-four cases and 144 controls were enrolled. Sensory loss in the fifth finger had the highest sensitivity (70.8%) compared with clinical findings. Motor conduction velocity across elbow reached the highest sensitivity (84.7%) in localizing ulnar neuropathy at the elbow recording from at least one of the two hand muscles (first dorsal interosseous and abductor digiti minimi). Abnormal sensory action potential amplitude from the fifth finger occurred more frequently in axonal than in demyelinating forms. Differences between retroepicondylar groove and humeroulnar arcade regarded conduction block and job type. Conclusions Clinical findings have less usefulness than electrodiagnostic testing in ulnar neuropathy at the elbow diagnosis. Motor conduction velocity across elbow recorded from both abductor digiti minimi and first dorsal interosseous increases diagnostic accuracy. Axonal forms have greater clinical and electrodiagnostic testing severity than demyelinating forms, which are more frequent in retroepicondylar groove. Manual workers prevailed in humeroulnar arcade. These findings may be helpful in prognostic and therapeutic approaches
Primrose sindrome (mental deficiency, ataxic spastic sindrome, muscle wasting, bone abnormalities with ossificationof pinnae, cataracts): report of the fourth case in the literature
No full textThe Primrose syndrome with progressive neurological involvement and cerebral calcification.
No full text
Peripheral neuropathy in CADASIL
No full textBACKGROUND:
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is a hereditary cerebral microangiopathy associated with mutations in the Notch 3 gene. The clinical phenotype is characterized by cerebral impairment even though typical microvascular changes are diffuse.
OBJECTIVE:
To assess peripheral neuropathy in patients with CADASIL.
PATIENTS AND METHODS:
We enrolled eleven CADASIL patients with variable phenotype including clinical signs of peripheral nerve involvement. In all patients electromyography and nerve conduction velocities were performed. Peripheral nerve biopsy was performed in three cases.
RESULTS:
We found sensory motor neuropathy in 7/11 patients. Nerve biopsy revealed axonal and demyelinated findings.
CONCLUSION:
Our findings suggest that peripheral neuropathy may be part of the CADASIL phenotype
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