1,721,046 research outputs found

    Effect of continuous and intermittent forces on human fibroblasts in vitro

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    Orthodontics is based upon the cellular response to biomechanical forces. However, little is known about the way cells respond to such forces. An experimental model has been designed to study the morphological and metabolic behaviour of human cells, subjected to cyclical or static mechanical loads. The model involves attaching human fibroblasts to silicone collagen-coated membranes, which are subjected to either continuous or cyclical stretching by a motor coupled with a movable supporting frame. The effect of continuous or cyclical stretching on the secretion of collagenase, an enzyme thought to play an important role in the process of tooth movement, was measured. Cyclical stretching of fibroblasts over a 4-day period, approximately doubled collagenase production as compared with the control. Continuous stretching, on the other hand, was only 50 per cent as effective in enhancing enzyme release. In contrast, the secretion of the collagenase inhibitor was unaffected by either form of ..

    Functional anterior limits of the dentition

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    The Authors propose a further evaluation, during diagnosis which can allow us to label the subject not only from static point of view but also from the functional one. They think that it would be very helpful to conduct a study for evaluation the eminence angle or better, the condylar guide

    Rescuing teeth from dentigerous cyst: a case report.

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    The goal of this treatment was the surgical- orthodontic rescue of the impacted teeth in a large dentigerous cyst, in a growing patient, by fixed orthodontic appliances. Initial and final records and progress in treatment are shown. The Authors demonstrate that a good result my be reached in this cases even if initial position of the cyst-associated teeth is critical and translocation of an adjacent tooth in the arch occurs

    Dental occlusion and temporomandibular disorders

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    Data sources Medline, Scopus and Google Scholar. Study selection Two reviewers selected studies independently. English language clinical studies assessing the association between temporomandibular disorders (TMD) and features of dental occlusion were considered. Data extraction and synthesis Study quality was assessed based on the Newcastle-Ottawa Scale (NOS) and a narrative synthesis was presented. Results In all 25 studies (17 case-control, eight comparative) were included. Overall there was a high variability between occlusal features and TMD diagnosis. Findings were consistent with a lack of clinically relevant association between TMD and dental occlusion. Only two studies were associated with TMD in the majority (=50%) of single variable analyses in patient populations. Only mediotrusive interferences are associated with TMD in the majority of multiple variable analyses. Conclusions The findings support the absence of a disease-specific association, there is no ground to hypothesise a major role for dental occlusion in the pathophysiology of TMDs. Dental clinicians are thus encouraged to move forward and abandon the old-fashioned gnathological paradig
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