97 research outputs found
sj-docx-1-eso-10.1177_23969873221094705 – Supplemental material for One-year healthcare costs of patients with spontaneous intracerebral hemorrhage treated in the intensive care unit
No full textSupplemental material, sj-docx-1-eso-10.1177_23969873221094705 for One-year healthcare costs of patients with spontaneous intracerebral hemorrhage treated in the intensive care unit by Marika Smeds, Markus B Skrifvars, Matti Reinikainen, Stepani Bendel, Sanna Hoppu, Ruut Laitio, Tero Ala-Kokko, Sami Curtze, Gerli Sibolt, Nicolas Martinez-Majander and Rahul Raj in European Stroke Journal</p
Supplemental material for Targets for improving dispatcher identification of acute stroke
No full textSupplemental Material for Targets for improving dispatcher identification of acute stroke by Olli S Mattila, Tuukka Puolakka, Juhani Ritvonen, Saana Pihlasviita, Heini Harve, Ari Alanen, Gerli Sibolt, Sami Curtze, Daniel Strbian, Mikko Pystynen, Turgut Tatlisumak, Markku Kuisma and Perttu J Lindsberg in International Journal of Stroke</p
ESO889468 Supplementary material - Supplemental material for Effect of haemoglobin levels on outcome in intravenous thrombolysis-treated stroke patients
No full textSupplemental material, ESO889468 Supplementary material for Effect of haemoglobin levels on outcome in intravenous thrombolysis-treated stroke patients by Valerian L Altersberger, Lars Kellert, Abdulaziz S Al Sultan, Nicolas Martinez-Majander, Christian Hametner, Ashraf Eskandari, Mirjam R Heldner, Sophie A van den Berg, Andrea Zini, Visnja Padjen, Georg Kägi, Alessandro Pezzini, Alexandros Polymeris, Gian M DeMarchis, Marjaana Tiainen, Silja Räty, Stefania Nannoni, Simon Jung, Thomas P Zonneveld, Stefania Maffei, Leo Bonati, Philippe Lyrer, Gerli Sibolt, Peter A Ringleb, Marcel Arnold, Patrik Michel, Sami Curtze, Paul J Nederkoorn, Stefan T Engelter, Henrik Gensicke and for the Thrombolysis in Stroke Patients (TRISP) collaborators in European Stroke Journal</p
Features of cerebral small-vessel disease and their association with long-term outcome in ischaemic stroke patients
No full textCerebral small-vessel disease (CSVD) is a common disease causing slowly progressive disability and earlier death. In CSVD, the destruction of subcortical networks leads to cognitive impairment, mood disorders, gait instability, and motor deficits. All those weaken the ability to be independent of help. Imaging features of CSVD can be visible on brain scans years before the first clinical symptoms. The imaging features are: cerebral white matter lesions (WML), cerebral microbleeds (CMB), perivascular spaces, brain atrophy, and lacunar infarcts.
The aim of this thesis was to investigate the features of cerebral small-vessel disease and their association with long-term outcome in ischaemic stroke patients.
The six publications were sub-studies of the Helsinki Stroke Aging Memory (SAM) study. The SAM cohort consists of 486 consecutive patients aged 55 to 85 years with ischaemic stroke who were admitted to Helsinki University Central Hospital. At 3 months, comprehensive clinical, neuropsychological, psychiatric, and radiological data were acquired. The cohort had a follow-up 21 years later using extensive national registers.
The findings of the six publications can be summarised as follows:
In post-stroke patients, the presence of WMLs was an indicator of ischaemic stroke recurrence up to 5 years after a first-ever ischaemic stroke and indicated a high risk of serious traumatic injuries, especially hip fractures requiring hospital treatment. After ischaemic stroke, patients with severe WMLs spent fewer days at home and became permanently institutionalised earlier, especially within the first 5 years.
In post-stroke patients, depression and especially depression-executive dysfunction syndrome were associated with a shorter interval to ischaemic stroke recurrence. Post-stroke dementia predicted the recurrence of ischaemic stroke at the long-term follow-up. Post-stroke dementia was a robust predictor of institutionalisation. Imaging and clinical features of CSVD were associated with unfavourable outcome events, like earlier recurrent stroke, traumatic injuries, and earlier permanent institutionalisation.Aivojen pienten suonten tauti on yleinen tauti, joka aiheuttaa hitaasti etenevää haittaa ja ennenaikaista kuolemaa. Pienten suonten taudissa subkortikaalisten verkkojen rappeutuminen johtaa kognitiivisiin häiriöihin, mielialahäiriöihin, tasapainovaikeuksiin ja motoorisiin puutosoireisiin. Kaikki nämä heikentävät omatoimisuutta. Pienten suonten taudin kuvantamislöydökset voivat näkyä aivokuvantamisessa jo vuosia ennen ensimmäisiä kliinisiä oireita. Kuvantamislöydökset ovat seuraavat: aivojen valkean aineen muutokset, aivojen mikrovuodot, perivaskulaaritilat, aivojen atrofia ja lakunaariset infarktit.
Tämä väitöskirjatyön tavoitteena oli, tutkia aivoverenkierron sairauksien ominaisuuksia ja niiden yhteyttä pitkäaikaisennusteeseen potilailla, joilla on ollut iskeeminen aivoinfarkti.
Väitöskirjan kuusi osatyöt olivat osa laajaa Helsinki Stroke Aging Memory (SAM)-tutkimusta. SAM-kohortti koostuu 486 perättäisestä 55–85-vuotiaasta Helsingin yliopistolliseen sairaalaan potilaista, joilla oli iskeeminen aivohalvaus. Kolmen kuukauden kohdalla tehtiin kertaalleen kattavia kliinisiä, neuropsykologisia, psykiatrisia ja radiologisia tutkimuksia. Kohorttia seurattiin 21 vuotta käyttäen hoitoilmoitusjärjestelmää, perusterveydenhuollon ja erikoissairaanhoidon potilastietojärjestelmiä, väestörekisterikeskuksen tietoja, ja kaupungin laitoshoitopäätöstietoja.
Kuuden osatöiden tiivistetyt tulokset olivat:
Potilailla, joilla oli aivohalvaus, valkean aineen muutokset ennustivat iskeemisen aivohalvauksen uusiutumisen jopa viiden vuoden ajan ensimmäisen iskeemisen aivohalvauksen jälkeen ja valkean aineen muutoksiin liittyi suurentunut riski saada sairaalahoitoa vaativia vakavia traumaattisia vammoja, erityisesti lonkkamurtumia. Iskeemisen aivohalvauksen jälkeen potilaat, joilla oli runsaasti valkean aineen muutoksia, viettivät vähemmän päiviä kotona ja joutuivat aikaisemmin pysyvään laitoshoitoon, erityisesti viiden ensimmäisen vuoden aikana.
Potilailla, joilla oli aivohalvaus, masennus ja erityisesti syndrooma jossa sekä masennus että heikentynyt toiminnanohjaus masennussyndrooma ennustivat aikaisempaa iskeemisen aivohalvauksen uusiutumista. Aivohalvauksen jälkeinen dementia ennustaa iskeemisen aivohalvauksen toistumista pitkäaikaisessa seurannassa. Aivohalvauksen jälkeinen dementia ennusti pysyvää laitoshoitoa.
Pienten suonten taudin kliiniset ja radiologiset ilmentymät ennustivat epäsuotuisia lopputulemia, kuten aikaisempaa aivohalvauksen uusiutumista, traumaattisia vammoja ja aikaisempaa pysyvään laitoshoitoon joutumista.ei saavutettav
EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients (EVA-TRISP) registry: basis and methodology of a pan-European prospective ischaemic stroke revascularisation treatment registry
No full textPurpose The Thrombolysis in Ischemic Stroke Patients (TRISP) collaboration was a concerted effort initiated in 2010 with the purpose to address relevant research questions about the effectiveness and safety of intravenous thrombolysis (IVT). The collaboration also aims to prospectively collect data on patients undergoing endovascular treatment (EVT) and hence the name of the collaboration was changed from TRISP to EVA-TRISP. The methodology of the former TRISP registry for patients treated with IVT has already been published. This paper focuses on describing the EVT part of the registry. Participants All centres committed to collecting predefined variables on consecutive patients prospectively. We aim for accuracy and completeness of the data and to adapt local databases to investigate novel research questions. Herein, we introduce the methodology of a recently constructed academic investigator-initiated open collaboration EVT registry built as an extension of an existing IVT registry in patients with acute ischaemic stroke (AIS). Findings to date Currently, the EVA-TRISP network includes 20 stroke centres with considerable expertise in EVT and maintenance of high-quality hospital-based registries. Following several successful randomised controlled trials (RCTs), many important clinical questions remain unanswered in the (EVT) field and some of them will unlikely be investigated in future RCTs. Prospective registries with high-quality data on EVT-treated patients may help answering some of these unanswered issues, especially on safety and efficacy of EVT in specific patient subgroups. Future plans This collaborative effort aims at addressing clinically important questions on safety and efficacy of EVT in conditions not covered by RCTs. The TRISP registry generated substantial novel data supporting stroke physicians in their daily decision making considering IVT candidate patients. While providing observational data on EVT in daily clinical practice, our future findings may likewise be hypothesis generating for future research as well as for quality improvement (on EVT). The collaboration welcomes participation of further centres willing to fulfill the commitment and the outlined requirements.Purpose The Thrombolysis in Ischemic Stroke Patients (TRISP) collaboration was a concerted effort initiated in 2010 with the purpose to address relevant research questions about the effectiveness and safety of intravenous thrombolysis (IVT). The collaboration also aims to prospectively collect data on patients undergoing endovascular treatment (EVT) and hence the name of the collaboration was changed from TRISP to EVA-TRISP. The methodology of the former TRISP registry for patients treated with IVT has already been published. This paper focuses on describing the EVT part of the registry. Participants All centres committed to collecting predefined variables on consecutive patients prospectively. We aim for accuracy and completeness of the data and to adapt local databases to investigate novel research questions. Herein, we introduce the methodology of a recently constructed academic investigator-initiated open collaboration EVT registry built as an extension of an existing IVT registry in patients with acute ischaemic stroke (AIS). Findings to date Currently, the EVA-TRISP network includes 20 stroke centres with considerable expertise in EVT and maintenance of high-quality hospital-based registries. Following several successful randomised controlled trials (RCTs), many important clinical questions remain unanswered in the (EVT) field and some of them will unlikely be investigated in future RCTs. Prospective registries with high-quality data on EVT-treated patients may help answering some of these unanswered issues, especially on safety and efficacy of EVT in specific patient subgroups. Future plans This collaborative effort aims at addressing clinically important questions on safety and efficacy of EVT in conditions not covered by RCTs. The TRISP registry generated substantial novel data supporting stroke physicians in their daily decision making considering IVT candidate patients. While providing observational data on EVT in daily clinical practice, our future findings may likewise be hypothesis generating for future research as well as for quality improvement (on EVT). The collaboration welcomes participation of further centres willing to fulfill the commitment and the outlined requirements
Can artificial intelligence help for scientific writing?
No full textShortly after initial publication of this article [1], the authorship and Acknowledgements were updated in line with Springer Nature authorship policies. Large Language Models (LLM), such as ChatGPT, do not currently satisfy our authorship criteria. An attribution of authorship carries with it accountability for the work, which cannot be effectively applied to LLMs [2]. The correct author byline reads: Michele Salvagno, Fabio Silvio Taccone & Alberto Giovanni Gerli The revised Acknowledgements read: For the writing of this article, we have not received funds or support from OpenAI, which is not associated with the entire process that led to the preparation of this article. The text, written with the support of the ChatGPT by OpenAI, has however been modified by the human authors, who assume full responsibility for form and content. The authorship list, Acknowledgements and Author contributions have been updated in the original article.SCOPUS: er.jinfo:eu-repo/semantics/publishe
Cardiovascular disease risk burden in primary Sjögren's syndrome: results of a population-based multicentre cohort study.
No full textCardiovascular disease risk burden in primary Sjögren's syndrome: results of a population-based multicentre cohort study.
Bartoloni E1, Baldini C, Schillaci G, Quartuccio L, Priori R, Carubbi F, Bini V, Alunno A, Bombardieri S, De Vita S, Valesini G, Giacomelli R, Gerli R.
Author information
Abstract
OBJECTIVE:
Systemic autoimmune diseases, in particular systemic lupus erythematosus and rheumatoid arthritis, are characterized by a high risk of premature cardiovascular (CV) events. Disease-related characteristics and traditional CV disease risk factors may contribute to atherosclerotic damage. However, there are limited data on the risk of overt CV events in primary Sjögren's syndrome (pSS).
METHODS:
We retrospectively analysed a cohort of patients with 1343 pSS. Disease-related clinical and laboratory data, traditional CV disease risk factors and overt CV events were recorded. Prevalence of traditional CV disease risk factors and of major CV events was compared between a subgroup of 788 female patients with pSS aged from 35 to 74 years and 4774 age-matched healthy women.
RESULTS:
Hypertension and hypercholesterolaemia were more prevalent, whereas smoking, obesity and diabetes mellitus were less prevalent, in women with pSS than in control subjects. Cerebrovascular events (2.5% vs. 1.4%, P = 0.005) and myocardial infarction (MI) (1.0% vs. 0.4%, P = 0.002) were more common in patients with pSS. In the whole population, central nervous system involvement (odds ratio (OR) 5.6, 95% confidence interval (CI) 1.35-23.7, P = 0.02) and use of immunosuppressive therapy (OR 1.9, 95% CI 1.04-3.70, P = 0.04) were associated with a higher risk of CV events. Patients with leucopenia had a higher risk of angina (P = 0.01).
CONCLUSIONS:
pSS is associated with an increased risk of cerebrovascular events and MI. Disease-related clinical and immunological markers may have a role in promoting CV events.
© 2015 The Association for the Publication of the Journal of Internal Medicine.
KEYWORDS:
Sjögren's syndrome; atherosclerosis; autoimmune disease; cardiovascular disease risk factor
Writing the past, ordering the world: Alfonso the Wise's Estorias within his political and cultural agenda
No full textThe purpose of this chapter is to analize from new perspectives the chronicles produced at King Alfonso X the Wise's scriptorium. After a brief overview of their general characteristics, I frame the composition of historical works within the extensive political and cultural program whose complexity can be better captured through Foucault?s concept of dispositf. Then, I analize several aspects of the singular character of the Alfonsine historiographical enterprise in relation to other contemporary historiographical traditions; the political moment of enunciation and the king?s enunciative position as author/authority of historiographical discourse. In third place, I analyze the manuscript production as it can be appreciated on the preserved royal codices, which helps us understand the original option for a romance language writing willing to order the world in terms of discursive practice as well as in terms of what Wittgenstein called "referential magic." Finally, this work aims at analyzing formally and ideologically the elements that compose the alphonsine historiographical model, through commenting specific passages of Estoria de España, both in its Versión Primitiva and its Versión Crítica, as well as the General Estoria. This work highlights the exceptional nature of the alphonsine cultural moment, which is be confirmed through an analysis of the alphonsine vision of translation and the powes of language and writing in significant passages of blblical history.Fil: Funes, Leonardo Ramon. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto de Investigaciones Bibliográficas y Crítica Textual. IIBICRIT - Subsede "Seminario Orduna"; Argentin
Globalizing Gramsci: The Resuscitation of a Repressed Intellectual
No full textIn the last four decades the name of Gramsci has spread well beyond the boundaries of Italian political theory and Marxist thought where it was originally confined, reaching disciplinary fields as diverse as literary criticism, sociology, communication studies, anthropology, international relations, history, and linguistics, and countries as far from Italy as Korea, India, and South Africa. Why this success and still before how this success has been possible? What social conditions had to be fulfilled to have Gramsci recognized as such a key author in so many intellectual fields and regions of the world? Making use of an exceptional data set, i.e. the Gramscian Bibliography created and managed by the “Gramsci institute” in Rome, which encompasses more than 19 thousands items (books, journal articles, conference proceedings about Gramsci, as well as the whole Gramscian production including translations and different editions), our research aims at tracing the global diffusion of Gramsci’s work in Italy and out of it since the 1940s, identifying patterns, trajectories, timing, agents, and modes of its reception in different national contexts and languages. Focusing on both translations of Gramscian texts and critical writings on and about Gramsci, the chapter will provide quantitative data about the global circulation of a thought whose international success has been certainly favored by Marxist internationalism and the Italian geopolitical location after WWII, but also hampered by the original language and the textual genres (private letters and personal notebooks written while in prison) in which it was embedded, as well as the strong national focus and disarming fragmentation of its content. We suggest that all these seemingly negative conditions exerted indeed a positive effect on the reception process, allowing for highly selective (and idiosyncratic) local appropriations, flexibility in publishing strategies, and the building of context-specific consecration strategies
Higher neutrophil counts before thrombolysis for cerebral ischemia predict worse outcomes
No full textObjective: To determine whether higher neutrophil counts before IV recombinant tissue plasminogen
activator (rtPA) administration in ischemic stroke (IS) patients are associated with symptomatic
intracerebral hemorrhages (sICH) and worse outcomes at 3 months.
Methods: Blood samples for leukocyte, neutrophil, and lymphocyte counts were drawn before IV
rtPA administration in IS patients included in the cohorts of Lille and Helsinki. The primary endpoint
was sICH (European Cooperative Acute Stroke–II definition). Secondary endpoints were
death and excellent (modified Rankin Scale [mRS] score 0–1 or equal to prestroke mRS) and good
(mRS score 0–2 or equal to prestroke mRS) outcomes at 3 months.
Results: We included 846 patients (median age 71 years; 50.8% men). The neutrophil count and
neutrophil to lymphocyte ratio (NLR) were independently associated with the 4 endpoints: sICH
(adjusted odds ratio [adjOR] for an increase of 1,000 neutrophils 5 1.21 and adjOR 1.11, respectively),
death (adjOR 1.16 and adjOR 1.08), and excellent (adjOR 0.87 and adjOR 0.85) and good
(adjOR 0.86 and adjOR 0.91) outcomes. The total leukocyte count was not associated with any of
the 4 endpoints. The best discriminating factor for sICH was NLR 4.80 had a 3.71-fold increased
risk for sICH (95%confidence interval adjOR: 1.97–6.98) compared to patients with NLR ,4.80.
Conclusions: Higher neutrophil counts and NLR are independently associated with sICH and
worse outcome at 3 months. The identification of mediators of this effect could provide new targets
for neuroprotection in patients treated by rtPA
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