1,722,477 research outputs found
Control of muscle differentiation in normal and pathological condition: the role of dystrophin and non coding RNAs
No full textMuscle differentiation is an excellent system to study the
mechanisms of transcriptional and post-transcriptional gene regulation in vertebrates. A regulatory circuitry in which competing endogenous RNAs (ceRNAs) act as a sponges to micro-RNAs was first demonstrated in in-vitro mouse myoblast differentiation for the muscle specific pro-myogenic long non coding RNA, linc-MD1. Here we characterized linc-hMD1, the human homologue of murine linc-MD1. We demonstrated that linc-hMD1 is down regulated in Dunchenne Muscular Dystrophy
(DMD) myoblast and it is rescued towards wild type levels in exon skipping treated cells. We showed that it can act as a sponge for miR-133. One of the interesting features of linc-hMD1 is that it is also the host transcript for miR-133b and the biogenesis of these two non-coding RNAs is mutually exclusive. Towards this we showed that the alternative biogenesis of linc-hMD1 and miR-133b
is regulated post transcriptionally through binding of HuR protein to pri-linc-hMD1 transcript. We studied the physiological relevance of this regulatory circuitry in human myoblast differentiation and showed that sponging activity of linc-hMD1 occurs during early stages of differentiation while at later stages,linc-hMD1 acts as a precursor for miR-133b.Sapienza-University of Rom
sj-docx-1-nms-10.1177_14614448221103534 – Supplemental material for Does distrust in humans predict greater trust in AI? Role of individual differences in user responses to content moderation
No full textSupplemental material, sj-docx-1-nms-10.1177_14614448221103534 for Does distrust in humans predict greater trust in AI? Role of individual differences in user responses to content moderation by Maria D. Molina and S. Shyam Sundar in New Media & Society</p
sj-docx-1-crx-10.1177_00936502211073398 – Supplemental material for Reading, Commenting and Sharing of Fake News: How Online Bandwagons and Bots Dictate User Engagement
No full textSupplemental material, sj-docx-1-crx-10.1177_00936502211073398 for Reading, Commenting and Sharing of Fake News: How Online Bandwagons and Bots Dictate User Engagement by Maria D. Molina, Jinping Wang, S. Shyam Sundar, Thai Le and Carlina DiRusso in Communication Research</p
sj-pdf-1-crx-10.1177_00936502211062778 – Supplemental material for Screenertia: Understanding “Stickiness” of Media Through Temporal Changes in Screen Use
No full textSupplemental material, sj-pdf-1-crx-10.1177_00936502211062778 for Screenertia: Understanding “Stickiness” of Media Through Temporal Changes in Screen Use by Miriam Brinberg, Nilam Ram, Jinping Wang, S. Shyam Sundar, James J. Cummings, Leo Yeykelis and Byron Reeves in Communication Research</p
Biogenesis and function of non-coding RNAs in muscle differentiation and in Duchenne muscular dystrophy
No full textIt is now becoming largely accepted that the non-coding portion of the genome, rather than its coding counterpart, is likely to account for the greater complexity of higher eukaryotes. Moreover, non-coding RNAs have been demonstrated to participate in regulatory circuitries that are crucial for development and differentiation. Whereas the biogenesis and function of small non-coding RNAs, particularly miRNAs (microRNAs), has been extensively clarified in many eukaryotic systems, very little is known about the long non-coding counterpart of the transcriptome. In the present review, we revise the current knowledge of how small non-coding RNAs and IncRNAs (long non-coding RNAs) impinge on circuitries controlling proper muscle differentiation and homoeostasis and how their biogenesis is regulated. Moreover, we provide new insights into an additional mechanism of post-transcriptional regulation mediated by IncRNAs, which, acting as miRNA 'sponges', have an impact on the distribution of miRNA molecules on their targets with features similar to those described for ceRNAs (competing endogenous RNAs).It is now becoming largely accepted that the non-coding portion of the genome, rather than its coding counterpart, is likely to account for the greater complexity of higher eukaryotes. Moreover, non-coding RNAs have been demonstrated to participate in regulatory circuitries that are crucial for development and differentiation. Whereas the biogenesis and function of small non-coding RNAs, particularly miRNAs (microRNAs), has been extensively clarified in many eukaryotic systems, very little is known about the long non-coding counterpart of the transcriptome. In the present review, we revise the current knowledge of how small non-coding RNAs and lncRNAs (long non-coding RNAs) impinge on circuitries controlling proper muscle differentiation and homoeostasis and how their biogenesis is regulated. Moreover, we provide new insights into an additional mechanism of post-transcriptional regulation mediated by lncRNAs, which, acting as miRNA 'sponges', have an impact on the distribution of miRN
Implementation of clean coal technologies to comply with "New Emission Norms" for thermal power plants - way forward for the Southern region. Summary Report of NITI Aayog-DST-NIAS Workshop, 17th September 2019 (NIAS/NSE/EEP/U/WR/13/2019)
Full text linkCoal based Thermal Power Plants (TPP) are the backbone of the power generation utilities in the country. Coal based TPPs constitute to around 56.1% of the total installed capacity and generates around 74.2% of the electricity generated in India. Considering the high pollution and resource impacts, of TPPs the Ministry of Environment, Forest and Climate Change (MoEF&CC) notified the Environment Protection (Amendment) Rules (EPAR) on December 5, 2015 with a two-year window for TPPs to meet these standards. When implemented, these norms are expected to have positive environmental and health benefits by leading to lower pollution levels from TPPs. However, compliance with the new emission norms would require retrofitting existing thermal power plants with various Pollution Control Technologies (PCT) in the form of auxiliary systems to control SO2, NOX and PM emissions. In order to ensure 24x7 supply of electricity, CPCB (in consultation with CEA) finalized the revised timelines for all TPPs to comply with the new emission norms by December 2022.
The team at Energy and Environment Programme (EEP) in NIAS, Bangalore interacted with various Power Plant Generation companies (GENCOs) in Southern Region to understand their challenges and way forward with respect to the huge capital investment and schedules for implementation. This team developed and a “Concept Paper” for a workshop with the theme, “Strategies and Action Plans needed for transition to an environment friendly and sustainable Electricity Source mix for the Southern Region”. This Workshop was held at NIAS on 17th September 2019 to enable key stakeholders - Power Plant Owners (Central & Southern States), Pollution Control Equipment Suppliers, Regulators and Policymakers to share their experience and deliberate on the challenges to develop a road map for implementation. This report presents the gist of each talk by the invited participants, and also consolidates the key findings and recommendations of the Workshop. This summary report will form the basis for further research as well as for policy advocacy with GOI through NITI Aayog. A.V. Krishnan, Shyam Sundar R, Shilpa Srivastava and R. Srikant
Balloon mitral valvotomy in pregnancy long term maternal and fetal outcomes(1)LV dyssynchrony: quantification by speckle tracking and tissue velocity derived strain in indices and comparison between subjects with or without systolic dysfunction and with or without left bundle-branch block(2)
No full textReplication Data for: Dicke superradiance requires interactions beyond nearest-neighbors
No full textPhoton-mediated interactions within an excited ensemble of emitters can result in Dicke superradiance, where the emission rate is greatly enhanced, manifesting as a high-intensity burst at short times. The superradiant burst is most commonly observed in systems with long-range interactions between the emitters, although the minimal interaction range remains unknown. Here, we put forward a new theoretical method to bound the maximum emission rate by upper bounding the spectral radius of an auxiliary Hamiltonian. We harness this tool to prove that for an arbitrary ordered array with only nearest-neighbor interactions in all dimensions, a superradiant burst is not physically observable. We show that Dicke superradiance requires minimally the inclusion of next-nearest-neighbor interactions. For exponentially decaying interactions, the critical coupling is found to be asymptotically independent of the number of emitters in all dimensions, thereby defining the threshold interaction range where the collective enhancement balances out the decoherence effects. Our findings provide key physical insights to the understanding of collective decay in many-body quantum systems, and the designing of superradiant emission in physical systems for applications such as energy harvesting and quantum sensing
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