17 research outputs found
Causes and predictors of death in South Africans with systemic lupus erythematosus
No full textFaculty of Health
School of Medicine
9101327d
[email protected] is known about the epidemiological and mortality patterns of systemic
lupus erythematosus (SLE) in Africa. Aims of this study- to determine the
demographics, clinical features and causes and predictors death in patients
attending the Lupus clinic at the Chris Hani Baragwanath hospital in
Soweto. Methods- the records of 226 patients who fulfilled American
College of Rheumatism criteria for the diagnosis of SLE were reviewed.
The mean (± SD) age at presentation was 34 (± 12.5) years. The female to
male ratio was 18:1. The commonest clinical feature found was arthritis in
70.4% of patients. Nephritis was present in 43.8% and CNS lupus in 15.9%
of patients. 55 patients in this group had died and 64 were lost to follow up.
The 5-year survival was 57% uncensored and 72% if censored for loss to
follow up. Infection (32.7%) was the commonest cause of death followed
by renal failure (16.4%). Nephritis, CNS lupus and hypocomplementaemia
were associated with mortality on univariate analysis. Lupus nephritis was
the only independant predictor of mortality on multivariate analysis.
Conclusion- this study confirms the poor outcome of SLE in the developing
world and demonstrates that renal disease is a factor commonly implicated
in mortality. The 5-year survival and pattern of mortality is similar to that
reported elsewhere in the developing worl
Maximising the efficiency of surveillance for COVID-19 in dialysis units in South Africa : the case for pooled testing
No full textThe COVID-19 epidemic in South Africa (SA) is currently in a growth phase with high incidences in most major cities. Patients who are dependent on chronic renal dialysis care, including peritoneal dialysis and haemodialysis, are chronically unwell and usually have multiple comorbidities including hypertension, diabetes and cardiovascular disease. These comorbidities are known to increase the risk of adverse outcomes for COVID-19, including hospitalisation with high care or intensive care admission, and/ or death. Haemodialysis patients throughout the country require facility-based support three times a week, and a typical dialysis visit is ~4 hours.The National Research Foundation of South Africahttp://www.samj.org.zaam2021Medical Microbiolog
Correction: Guidelines for the prevention, detection and management of the renal complications of COVID-19 in Africa
No full textThe authors of the article ‘Guidelines for the prevention, detection and management of the renal complications of COVID-19 in Africa’ [1] wish to acknowledge the contribution of Professor Hussein El Fishawy. Our guidelines drew on various sources, including the Egyptian Ministry of Health guidelines, portions of which were adapted and reproduced with permission from the Egyptian Ministry of Health. Two of the authors of those guidelines, Professors Elsayed and Zaki, are also coauthors of our paper. Professor El Fishawy was the third author of the Egyptian guidelines and we would like to acknowledge his contribution to our review through this source, especially with respect to the treatment algorithms for patients with kidney transplants and those with acute kidney injury. Reference1. Elsayed HM, Wadee S, Zaki MS, Were AJO, Ashuntantang GE, Bamgboye EL, et al. Guidelines for the prevention, detection and management of the renal complications of COVID-19 in Africa. Afr J Nephrol. 2020; 23(1):109-126
A call to action: Temporal trends of COVID-19 deaths in the South African Muslim community
No full textNo abstract
Asymptomatic papules and nodules on forehead and limbs: CPD • Clinicopathological case
No full text[No abstract available]CAPUTO R, 1995, ARCH DERMATOL, V131, P459, DOI 10.1001-archderm.131.4.459; Carder KR, 2003, PEDIATR DERMATOL, V20, P35, DOI 10.1046-j.1525-1470.2003.03008.x; Colomb D, 1973, LYON MED, V230, P470; Cowen EW, 2004, J AM ACAD DERMATOL, V50, pS97; Nagaraj LV, 2006, J AM ACAD DERMATOL, V55, P1036, DOI 10.1016-j.jaad.2006.06.024; WADEE S, 1994, CLIN EXP DERMATOL, V19, P90, DOI 10.1111-j.1365-2230.1994.tb01129.x12
Vitalistic information systems in the South African public health system : a transactional analysis perspective
No full textIncludes bibliographical references
Behaviour and design of prestressed columns
No full textThe load-carrying capacity of slender columns is limited by global instability. However,
through the addition of strategically placed cross-arms and external prestressed cables,
buckling displacements can be inhibited and the load-carrying capacity considerably enhanced.
Such systems, known as prestressed stayed columns offer efficient and lightweight
structural solutions.
Previous research on prestressed stayed columns has been largely analytical and numerical
studies. To the knowledge of the author, experimental investigations into the antisymmetric
and interactive modes of buckling in stayed columns have not been attempted hitherto.
In addition, although some previous studies have attempted to investigate the optimum
prestressing configuration of stayed columns for design purposes, generic design guidance
for this type of structural component has been lacking. Therefore, the primary aim of the
current study is to conduct experimental and numerical investigations into the possible
buckling and post-buckling behaviour and to develop an efficient design method for these
structural components.
A full scale experimental investigation has been conducted with a total of 18 test specimens
to demonstrate the critical modes of buckling (symmetric and antisymmetric) with
interactive post-buckling. This has also investigated the imperfection sensitivity of the
stayed columns. Nonlinear finite element (FE) modelling was conducted in parallel with
the experiments. These models were utilized, after successful validation against the experimental
results, to investigate the sensitivity of the stayed system to the variation of key
parameters.
Subsequently, an efficient design method for prestressed stayed columns has been developed,
including design charts and equations relating the resistance of the stayed column
system to the level of the initial prestress in the cables for varying cross-arm lengths and
global imperfection levels. Structural reliability analysis, using the procedures in Annex
D of EN 1990, was conducted to evaluate the design safety factor. Worked examples of
the proposed design method are also presented to demonstrate the developed procedure
for diiferent key cases. It is shown that a straightforward yet rational design method has
been formulated
On the interaction of uni-directional and bi-directional buckling of a plate supported by an elastic foundation
No full textThis is the author accepted manuscript. The final version is available from the Royal Society via the DOI in this record.A thin flat rectangular plate supported on its edges and subjected to in-plane loading exhibits stable post-buckling behaviour. However, the introduction of a nonlinear (softening) elastic foundation may cause the response to become unstable. Here the post-buckling of such a structure is investigated and several important phenomena are identified, including the transition of patterns from stripes to spots and back again. The interaction between these forms is of importance for understanding the possible post-buckling behaviours of this structural system. In addition, both periodic and some localized responses are found to exist as the dimensions of the plate are increased and this becomes relevant when the characteristic wavelengths of the buckle pattern are small compared to the size of the plate. Potential application of the model range from macroscopic industrial manufacturing of structural elements to the understanding of micro- and nano-scale deformations in materials
Uniquely South African: Time to Consider Offering HIV-Positive Donor Kidneys to HIV-Infected Renal Failure Patients?
No full text
