21 research outputs found
STUDIES ON THE SEPARATION OF VARIOUS HORMONES BY THE HIGH VOLTAGE PAPER-ELECTROPHORESIS I. ON THE PREGNANDIOL GLUCURONIDE IN URINE (PRELIMINARY REPORT)
No full text日本近世の亀趺碑 : 中国および朝鮮半島の歴代亀趺碑との比較を通して
No full textIn this paper, author first investigates tortoisebased Stelae from the Eastern Han Dynasty in China and from the Unified Silla Dynasty in Korea, via achievenents in research since SEKINO Tadashi 関野貞, and positions those stelae within those prescriptions which succed the ideas of tomb regulation, from the Wei dynasty. Since the Sui-Tang dynasties, these regulations had been made severely by status, in the Ming dynasty, tor-toisebased stelae such as Shen-dao-bei 神道碑, which was built alongside the spirit road, were permitted to those above the third rank of peerage. Generally memorial monuments, were permitted to those above the fifth rank, other than Gods whose rank no one could deny, to whom they were permitted in any case. Secondly, upon recognizing that no study on tortoisebased stelae had been undertaken on a nationwide scale, the author investigates many reports which were made about several stelae, and surveyed every stele to investi-gate its relation to tombs. He induces that regulations of stelae in the Edo Period, When these stelae were begun to be made in Japan, fundamentally followed those of the Ming dynasty. They probably made much of the third rank of ‘samurai\u27peerage, as those stelae including Shen-dao-bei which were built in front of tombs, and made much of fifth rank, as the other memorial monuments of literary or military men did. But, as a Japanese style, they only very rarely featured stele crowns decorated with tow dragons, which were permitted to higher ranks, but often used facestones with square pillars, which were permitted to lower ranks. As a formative style, they often used those of the latter Silla and Koryo period in Korea, whose characteristic was erect neck and wild beast\u27s head in body-frame, not the usual tortoise\u27s, and which were used as stupa monuments for highly ranked priests. later than these, stelae appeared in part Chinese style. These were parallel with the phenomenon that those stelae in Japan were often related with Buddhism. The Tokugawa shogunate gave tacit warnings against ‘DaimyO\u27erecting tortoisebased stelae for tombs. Adding this to above induction, the author concludes; this was resulted from the shogunate resented ‘Tenno\u27being regarded as the external representative of Japan, through tortoisedbased stelae, which pointed out concretely and historically the political system of East Asia, rather than the regulation of stelae raising ‘Tenno\u27\u27s dignity through the rank of ‘samurai\u27peerage. With the ‘Taiknn\u27title, which was independent of ‘samurai\u27peerage, the Tokugawa ‘Shogun\u27had to be the sole external representative of Japan. Therefore, it was considered wise to build tortoisebased stelae of tombs by interposing Buddhism and making vague the regulation of ‘samurai\u27peerage
人胎盤中に含有する特異蛋白の血清免疫学的研究
No full textRabbits were immunized repeatedly (ten times) with the extract of human placenta, and with these rabbits' anti-sera the precipitin reaction was investigated, the following are the results: 1) These anti-sera contained the precipitins reacting on human, fetal and umbilical cord blood sera as well as human placental extract, fetal hemoglobin and amnion water. 2) After absorption of these anti-sera with human, they contained yet some precipitins reacting on human placental extract, fetal, umbilical cord blood sera, amnion water and fetal hemoglobin. They reacted on some pregnant women's sera, and did not on the others. 3) After the absorption of the anti-sera, which were already absobed anti-human sera precipitin, with fetal blood sera or fetal hemoglobin, they did not react on the above mentioned reaction antigens in the former case, but they reacted on them in the latter, though it was weak. 4) It was considered from these data that some specific protein fractions, which were not contained in the adult human sera, were contained in the human placental extract. As J. HIRASE in our laboratory confirmed that the fetal blood sera contained some specific protein fractions, it was also considered that these two fractions were the same. It was suggested by this author that the specific antibody was not the same with the reacting antigen of fetal hemoglobin
Sero-immunological studies of the specific protein contained in human placenta
No full textRabbits were immunized repeatedly (ten times) with the extract of human placenta, and with these rabbits' anti-sera the precipitin reaction was investigated, the following are the results: 1) These anti-sera contained the precipitins reacting on human, fetal and umbilical cord blood sera as well as human placental extract, fetal hemoglobin and amnion water. 2) After absorption of these anti-sera with human, they contained yet some precipitins reacting on human placental extract, fetal, umbilical cord blood sera, amnion water and fetal hemoglobin. They reacted on some pregnant women's sera, and did not on the others. 3) After the absorption of the anti-sera, which were already absobed anti-human sera precipitin, with fetal blood sera or fetal hemoglobin, they did not react on the above mentioned reaction antigens in the former case, but they reacted on them in the latter, though it was weak. 4) It was considered from these data that some specific protein fractions, which were not contained in the adult human sera, were contained in the human placental extract. As J. HIRASE in our laboratory confirmed that the fetal blood sera contained some specific protein fractions, it was also considered that these two fractions were the same. It was suggested by this author that the specific antibody was not the same with the reacting antigen of fetal hemoglobin
Author Correction: Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance
No full textAuthor Correction: Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance
No full textAn amendment to this paper has been published and can be accessed via a link at the top of the paper
Empagliflozin Induces Transient Diuresis without Changing Long-term Overall Fluid Balance in Japanese Patients with Type 2 Diabetes
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be found here. https://link.springer.com/article/10.1007/s13300-018-0385-5Provide enhanced content for this
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Long-Term Safety and Effectiveness of Linagliptin in Japanese Patients with Type 2 Diabetes and Renal Dysfunction: A Post-Marketing Surveillance Study
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This Figshare page contains a Summary Slide. If you are an author of this publication and
would like to provide additional enhanced digital features for your article
then please contact [email protected].
The journal offers a range of additional features designed to increase
visibility and readership. All features will be thoroughly peer reviewed to
ensure the content is of the highest scientific standard and all features are
marked as ‘peer reviewed’ to ensure readers are aware that the content has been
reviewed to the same level as the articles they are being presented alongside.
Moreover, all sponsorship and disclosure information is included to provide
complete transparency and adherence to good publication practices. This ensures
that however the content is reached the reader has a full understanding of its
origin. No fees are charged for hosting additional open access content.
Other enhanced features include, but are not limited to:
• Slide decks
• Videos and animations
• Audio abstracts
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Prognostic factors of functional outcome in acute ischemic stroke
No full textTrombolyse is een behandeling waarbij een stolsel in een bloedvat wordt opgelost door het gebruik van anti-bloedstollingsmiddelen. Irene Miedema deed onderzoek naar veiligheidsaspecten van trombolyse.
Door de ontwikkeling van trombolyse is de zorg aan patiënten met een acuut herseninfarct de afgelopen decennia sterk verbeterd. De behandeling is echter alleen voor een selecte groep beschikbaar en is niet zonder risico’s.
Miedema bestudeerde een groep van ruim 700 patiënten. Zij vond dat trombolyse na drie maanden geen verbeterde klinische uitkomst gaf, wanneer deze patiënten voor het herseninfarct een bepaald soort antidepressivum (SSRI), een cholesterolverlagend middel (statine) of urinezuur gebruikten. De promovenda constateert dat dat ook het geval was wanneer de bloedsuikerspiegel bij aanvang van de behandeling te hoog was. Tot slot ontdekte ze dat behandeling met een vitamine K antagonist (een anti-bloedstollingsmiddel) bij patiënten met een normale of licht verhoogde bloedstollingswaarde leidde tot een verhoogd risico op het ontwikkelen van een hersenbloeding.
Omdat trombolyse nog steeds de eerste keus behandeling is, is het voor de veiligheid van patiënten extra van belang dat artsen daarvoor de juiste patiënten selecteren. Deze uitkomsten kunnen daarbij helpen.
In the last decades, the development of revascularisation therapy with intravenous recombinant tissue plasminogen antigen (tPA) has greatly improved the outcome of acute ischemic stroke patients, but this therapy is only available for a selected group of patients and has safety concerns. In this thesis several possible neuroprotective agents in acute ischemic stroke and some safety aspects of tPA-treatment are discussed. In a cohort of patients with acute ischemic stroke treated with intravenous tPA no improvement of functional outcome at 3 months after the event was found in patients using selective serotonin re-uptake inhibitor (SSRI) or statin. Serum uric acid levels were also unrelated to improvement outcomes in patients with acute ischemic stroke. Concerning safety, for all stroke subtypes, hyperglycemia during admission was associated with a poor functional outcome in patients treated with tPA. Using vitamin-K-antagonist in patients with normal or slightly elevated International Normalized Ratio (INR) who are treated with tPA, is associated with the risk of symptomatic intracranial hemorrhage (SICH), but not with the actual functional outcome at 3 months after ischemic stroke. In conclusion, the studies in this thesis do not support a neuroprotective effect of SSRIs, statins and serum uric acid levels in patients with acute ischemic stroke. Treatment with tPA is still the most effective therapy for acute ischemic stroke and selection of patients to reduce treatment risks is important. Use of vitamin-K-antagonist with elevated INR and admission hyperglycemia are associated with the occurrence of SICH and poor functional outcome respectively.
