1,388 research outputs found
Hierarchical Representations of Freebase Topics
No full textThe dataset contains more than 21M hierarchical relationships about ≈10M topics extracted from Freebase knowledgebase. The topics span the various categories of Freebase including Science & Technology, Arts & Entertainment, Sports, Society, Products & Services, Transportation, Time & Space, Special Interests, and Commons. The relationships describe the hierarchies of topics in terms of Types, Domains, and Categories. For example, ‘Albert Einstein’ can be found as a topic that is a sub-class of ‘Person’, belonging to the ‘People’ domain and ‘Society’ category. Another entity named as ‘Albert Einstein’ can also be found as a sub-class of ‘Book’, belonging to the ‘Books’ domain and ‘Arts & Entertainment’ category. The dataset is published in JSON and CSV formats, sample files are provided to help explore how the dataset is structured. The dataset is believed to be useful for studying the inter-related connections among topics in different domains of knowledge. The first author may be contacted at ([email protected]) for more information. The following paper may kindly be cited in case of using the dataset. Mahmoud Elbattah, Mohamed Roushdy, Mostafa Aref, Abdel-Badeeh M. Salem. “Large-Scale Entity Clustering Using Graph-Based Structural Similarity within Knowledge Graphs”, Big Data Analytics: Tools, Technology for Effective Planning, CRC Press. https://www.researchgate.net/publication/321716589_Large-Scale_Entity_Clustering_Based_on_Structural_Similarity_within_Knowledge_Graph
Hierarchical Representations of Freebase Topics
No full textThe dataset contains more than 21M hierarchical relationships about ≈10M topics extracted from Freebase knowledgebase. The topics span the various categories of Freebase including Science & Technology, Arts & Entertainment, Sports, Society, Products & Services, Transportation, Time & Space, Special Interests, and Commons. The relationships describe the hierarchies of topics in terms of Types, Domains, and Categories. For example, ‘Albert Einstein’ can be found as a topic that is a sub-class of ‘Person’, belonging to the ‘People’ domain and ‘Society’ category. Another entity named as ‘Albert Einstein’ can also be found as a sub-class of ‘Book’, belonging to the ‘Books’ domain and ‘Arts & Entertainment’ category. The dataset is published in JSON and CSV formats, sample files are provided to help explore how the dataset is structured. The dataset is believed to be useful for studying the inter-related connections among topics in different domains of knowledge. The first author may be contacted at ([email protected]) for more information. The following paper may kindly be cited in case of using the dataset. Mahmoud Elbattah, Mohamed Roushdy, Mostafa Aref, Abdel-Badeeh M. Salem. “Large-Scale Entity Clustering Using Graph-Based Structural Similarity within Knowledge Graphs”, Big Data Analytics: Tools, Technology for Effective Planning, CRC Press. https://www.researchgate.net/publication/321716589_Large-Scale_Entity_Clustering_Based_on_Structural_Similarity_within_Knowledge_Graph
Benefits of Chlorella vulgaris against Cadmium Chloride-Induced Hepatic and Renal Toxicities via Restoring the Cellular Redox Homeostasis and Modulating Nrf2 and NF-KB Pathways in Male Rats
No full textIn our life scenarios, we are involuntarily exposed to many heavy metals that are well-distributed in water, food, and air and have adverse health effects on animals and humans. Cadmium (Cd) is one of the most toxic 10 chemicals reported by The World Health Organization (WHO), affecting organ structure and function. In our present study, we use one of the green microalga Chlorella vulgaris (ChV, 500 mg/kg body weight) to investigate the beneficial effects against CdCl2-induced hepato-renal toxicity (Cd, 2 mg/kg body weight for 10 days) on adult male Sprague-Dawley rats. In brief, 40 adult male rats were divided into four groups (n = 10); Control, ChV, Cd, and Cd + ChV. Cadmium alters liver and kidney architecture and disturbs the cellular signaling cascade, resulting in loss of body weight, alteration of the hematological picture, and increased ALT, AST, ALP, and urea in the blood serum. Moreover, cadmium puts hepatic and renal cells under oxidative stress due to the up-regulation of lipid peroxidation resulting in a significant increase in the IgG level as an innate immunity protection and induction of the pro-inflammatory cytokines (IL-1β and TNF-α) that causes hepatic hemorrhage, irregular hepatocytes in the liver and focal glomeruli swelling and proximal tubular degeneration in the kidney. ChV additive to CdCl2, could organize the protein translation process via NF-kB/Nrf2 pathways to prevent oxidative damage by maintaining cellular redox homeostasis and improving the survival of and tolerance of cells against oxidative damage caused by cadmium. The present study shed light on the anti-inflammatory and antioxidative properties of Chlorella vulgaris that suppress the toxicity influence of CdCl2
Dunaliella salina Microalga Restores the Metabolic Equilibrium and Ameliorates the Hepatic Inflammatory Response Induced by Zinc Oxide Nanoparticles (ZnO-NPs) in Male Zebrafish
No full textMicroalgae are rich in bioactive compounds including pigments, proteins, lipids, polyunsaturated fatty acids, carbohydrates, and vitamins. Due to their non-toxic and nutritious characteristics, these are suggested as important food for many aquatic animals. Dunaliella salina is a well-known microalga that accumulates valuable amounts of carotenoids. We investigated whether it could restore the metabolic equilibrium and mitigate the hepatic inflammation induced by zinc oxide nanoparticles (ZnO-NPs) using male zebrafish which were exposed to 1/5th 96 h-LC50 for 4 weeks, followed by dietary supplementation with D. salina at two concentrations (15% and 30%) for 2 weeks. Collectively, ZnO-NPs affected fish appetite, whole body composition, hepatic glycogen and lipid contents, intestinal bacterial and Aeromonas counts, as well as hepatic tumor necrosis factor- α (TNF-α). In addition, the mRNA expression of genes related to gluconeogenesis (pck1, gys2, and g6pc3), lipogenesis (srepf1, acaca, fasn, and cd36), and inflammatory response (tnf-α, tnf-β, nf-kb2) were modulated. D. salina reduced the body burden of zinc residues, restored the fish appetite and normal liver architecture, and mitigated the toxic impacts of ZnO-NPs on whole-body composition, intestinal bacteria, energy metabolism, and hepatic inflammatory markers. Our results revealed that the administration of D. salina might be effective in neutralizing the hepatotoxic effects of ZnO-NPs in the zebrafish model
Origanum vulgare Essential Oil Modulates the AFB1-Induced Oxidative Damages, Nephropathy, and Altered Inflammatory Responses in Growing Rabbits
No full textThe current study was performed to investigate the toxic effects of aflatoxin B1 (AFB1) through the evaluation of kidney function tests and histopathological examination of renal tissues, targeting the therapeutic role of Marjoram (Origanum vulgare essential oil-OEO) in improving health status. Forty-eight New Zealand Whites growing rabbits (four weeks old) weighing on average 660.5 ± 2.33 g were randomly and equally distributed into four groups, each of which had four replicas of three animals as the following: Control group (only basal diet), AFB1 group (0.3 mg AFB1/kg diet), OEO group (1 g OEO/kg diet) and co-exposed group (1 g OEO/kg + 0.3 mg AF/kg diet). Our study lasted eight weeks and was completed at 12 weeks of age. The results revealed that OEO decreased the toxic effects of AFB1 in rabbit kidneys by substantially reducing the cystatin C levels in the AFB1 group. Additionally, OEO decreased oxidative stress and lipid peroxidation levels in the co-exposed group. Moreover, OEO reduced DNA damage and inflammatory response in addition to the down-regulation of stress and inflammatory cytokines-encoding genes. Besides, OEO preserved the cytoarchitecture of rabbits’ kidneys treated with AFB1. In conclusion, O. vulgare essential oil supplementation ameliorated the deleterious effects of AFB1 on the rabbits’ kidneys by raising antioxidant levels, decreasing inflammation, and reversing oxidative DNA damage
Modulatory effect of thymol on the immune response and susceptibility to Aeromonas hydrophila infection in Nile tilapia fish exposed to zinc oxide nanoparticles
No full textZinc oxide nanoparticles (ZnO-NPs) have many exciting properties that make their use in a continuous increase in various biomedical, industrial, and agricultural applications. This is associated with accumulation in the aquatic ecosystems and fish exposure with consequent deleterious effects. To determine the potential of thymol to counteract the immunotoxic effects of ZnO-NPs, Oreochromis niloticus was exposed to ZnO-NPs (1⁄5 LC50 =1.14 mg/L, for 28 days) with or without feeding a thymol-incorporated diet (1 or 2 g/kg diet). Our data demonstrated a reduction of aquaria water quality, leukopenia, and lymphopenia with a decrease in serum total protein, albumin, and globulin levels in exposed fish. At the same time, the stress indices (cortisol and glucose) were elevated in response to ZnO-NPs exposure. The exposed fish also revealed a decline in serum immunoglobulins, nitric oxide, and the activities of lysozyme and myeloperoxidase, in addition to reduced resistance to the Aeromonas hydrophila challenge. The RT-PCR analysis showed downregulation of antioxidant (SOD) superoxide dismutase and (CAT) catalase gene expression in the liver tissue with overexpression of the immune-related genes (TNF-α and IL-1β). Importantly, we found that thymol markedly protected against ZnO-NPs-induced immunotoxicity in fish co-supplemented with thymol (1 or 2 g/kg diet) in a dose-dependent manner. Our data confirm the immunoprotective and antibacterial effects of thymol in ZnO-NPs exposed fish, supporting the potential utility of thymol as a possible immunostimulant agent
Astaxanthin Mitigates Thiacloprid-Induced Liver Injury and Immunotoxicity in Male Rats
No full textThiacloprid (TCP) is a widely used neonicotinoid insecticide with a probable toxic hazard to animals and human beings. This hazard has intensified the demand for natural compounds to alleviate the expected toxic insults. This study aimed at determining whether astaxanthin (ASX) could mitigate the hepatotoxic effect of TCP and diminish its suppressive effect on immune responses in rats. Animals received TCP by gavage at 62.1 mg/kg (1/10th LD50) with or without ASX at 40 mg/kg for 60 days. Intoxicated rats showed modulation of serum transaminases and protein profiles. The hemagglutination antibody titer to sheep red blood cells (SRBC) and the number of plaque-forming cells in the spleen were reduced. The cell-mediated immunity and phagocytosis were suppressed, while serum interleukins IL-1β, IL-6, and IL-10 were elevated. Additionally, malondialdehyde, nitric oxide, and 8-hydroxy-2′-deoxyguanosine levels were increased in the liver, spleen, and thymus, with depletion of glutathione and suppression of superoxide dismutase and catalase activities. The expressions of inducible nitric oxide synthase and the high mobility group box protein 1 genes were upregulated with histomorphological alterations in the aforementioned organs. Cotreatment with ASX markedly ameliorated the toxic effects of TCP, and all markers showed a regression trend towards control values. Collectively, our data suggest that the protective effects of ASX on the liver and immune system of TCP-treated animals depend upon improving the antioxidant status and relieving the inflammatory response, and thus it may be used as a promising therapeutic agent to provide superior hepato- and immunoprotection
Dunaliella salina Microalga Restores the Metabolic Equilibrium and Ameliorates the Hepatic Inflammatory Response Induced by Zinc Oxide Nanoparticles (ZnO-NPs) in Male Zebrafish
No full textMicroalgae are rich in bioactive compounds including pigments, proteins, lipids, polyunsaturated
fatty acids, carbohydrates, and vitamins. Due to their non-toxic and nutritious characteristics,
these are suggested as important food for many aquatic animals. Dunaliella salina is a well-known microalga that accumulates valuable amounts of carotenoids. We investigated whether it could restore the metabolic equilibrium and mitigate the hepatic inflammation induced by zinc oxide nanoparticles (ZnO-NPs) using male zebrafish which were exposed to 1/5th 96 h-LC50 for 4 weeks, followed by dietary supplementation with D. salina at two concentrations (15% and 30%) for 2 weeks. Collectively, ZnO-NPs affected fish appetite, whole body composition, hepatic glycogen and lipid contents, intestinal bacterial and Aeromonas counts, as well as hepatic tumor necrosis factor-a (TNF-a). In addition, the mRNA expression of genes related to gluconeogenesis (pck1, gys2, and g6pc3), lipogenesis (srepf1, acaca, fasn, and cd36), and inflammatory response (tnf-a, tnf-b, nf-kb2) were modulated. D. salina reduced the body burden of zinc residues, restored the fish appetite and normal liver architecture, and mitigated the toxic impacts of ZnO-NPs on whole-body composition, intestinal bacteria, energy metabolism, and hepatic inflammatory markers. Our results revealed that the administration of D. salina might be effective in neutralizing the hepatotoxic effects of ZnO-NPs in the zebrafish model
Implementation in Altran for Rational Function Integration and Polynomial Factorization
No full textTitle: Implementation in Altran for Rational Function Integration and Polynomial Factorization , Author: Mahmoud M. Makhlouf, Location: ThodeThis project is a study involving the application of the ALTRAN system to rational function integration. A discussion and the implementation of two methods are given, one by Hermite [HER 12] and a second by Horowitz [HOR 70]. Included is a brief discussion of the integration of the transcendental part over the rational field using polynomial factorization over the integers. Furthermore, an extension for multivariate rational function integration and
multivariate polynomial factorization is included.ThesisMaster of Science (MS
Gaya Bahasa dalam Puisi Aḥinnu ilá Khubzi Ummī Karya Mahmoud Darwish
No full textLiterature is an art mediated by language, while literary works are a product of imagination with the medium of language. A poem is a literary work that has a dense language of figures and symbols. Therefore, research is needed to analyse the meaning of a poem. One of the analyses of poem research is using stylistic analysis. The poem that is the object of this study is the poem Aḥinnu ilá Khubzi Ummī by Mahmoud Darwish. This poem describes the poet's longing for his mother, which is full of figurative language. This study aims to describe the various styles of language in the poem Aḥinnu ilá Khubzi Ummī by Mahmoud Darwish. The method used is a content analysis by describing the form of language style in Mahmoud Darwish’s poem. The results of this study indicate that the author uses several language styles in the poem, which include (1) hyperbole, (2) paradox, and (3) personification
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