1,909 research outputs found

    Significance of smoking machine toxicant yields to blood-level exposure in water pipe tobacco smokers

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    Background: The global increase in tobacco smoking with a water pipe (hookah, narghile, or shisha) has made understanding its health consequences imperative. One key to developing this understanding is identifying and quantifying carcinogens and other toxicants present in water pipe smoke. To do so, the toxicant yield of machine-generated water pipe smoke has been measured. However, the relevance of toxicant yields of machine-generated smoke to actual human exposure has not been established. Methods: In this study, we examined whether carbon monoxide (CO) and nicotine yields measured with a smoking machine programmed to replicate the puffing behavior of 31 human participants whosmoked a water pipe could reliably predict these participants' blood-level exposure. In addition to CO and nicotine, yields of polyaromatic hydrocarbons, volatile aldehydes, nitric oxide (NO), and tar were measured. Results: We found that when used in this puff-replicating manner, smoking machine yields are highly correlated with blood-level exposure (nicotine: r 0.76, P 0.001; CO: r 0.78, P 0.001). Total drawn smoke volume was the best predictor of toxicant yield and exposure, accounting for approximately 75percent to 100percent of the variability across participants in yields of NO, CO, volatile aldehydes, and tar, as well as blood-level CO and normalized nicotine. Conclusions: Machine-based methods can be devised in which smoke toxicant yields reliably track human exposure. Impact: This finding indicates the basic feasibility of valid analytic laboratory evaluation of tobacco products for regulatory purposes. ©2011 AACR.ALRASHIDI M, 2008, FOOD CHEM TOXICOL, V35, P546; Blank MD, 2011, DRUG ALCOHOL DEPEN, V116, P102, DOI 10.1016-j.drugalcdep.2010.11.026; Djordjevic MV, 2000, J NATL CANCER I, V92, P106, DOI 10.1093-jnci-92.2.106; Hammond D, 2006, CANCER EPIDEM BIOMAR, V15, P1495, DOI 10.1158-1055-9965.EPI-06-0047; HEMING RI, 1983, CLIN PHARMACOL THER, V33, P84; JOHNSTON LD, 2011, MONITOR FUTURE NATL; Katurji M, 2010, INHAL TOXICOL, V22, P1101, DOI 10.3109-08958378.2010.524265; Monzer B, 2008, FOOD CHEM TOXICOL, V46, P2991, DOI 10.1016-j.fct.2008.05.031; NADLER SB, 1962, SURGERY, V51, P224; Sepetdjian E, 2008, FOOD CHEM TOXICOL, V46, P1582, DOI 10.1016-j.fct.2007.12.028; Shihadeh A, 2006, J AEROSOL MED, V19, P137, DOI 10.1089-jam.2006.19.137; Shihadeh A, 2003, FOOD CHEM TOXICOL, V41, P143, DOI 10.1016-S0278-6915(02)00220-X; Shihadeh A, 2005, FOOD CHEM TOXICOL, V43, P655, DOI 10.1016-j.fct.2004.12.01387

    Waterpipe tobacco smoking: An emerging health crisis in the United States

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    Objective: To examine the prevalence and potential health risks of waterpipe tobacco smoking. Methods: A literature review was performed to compile information relating to waterpipe tobacco smoking. Results: Waterpipe tobacco smoking is increasing in prevalence worldwide; in the United States, 10-20percent of some young adult populations are current waterpipe users. Depending on the toxicant measured, a single waterpipe session produces the equivalent of at least 1 and as many as 50 cigarettes. Misconceptions about waterpipe smoke content may lead users to underestimate health risks. Conclusion: Inclusion of waterpipe tobacco smoking in tobacco control activities may help reduce its spread. Copyright © PNG Publications 2011 All Rights Reserved.Al-Arifi M. 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    Nicotine exposure in daily waterpipe smokers and its relation to puff topography

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    Waterpipe tobacco smoking is increasing in popularity worldwide and available evidence point to its addictive and harmful potential. This study is conducted to assess nicotine exposure in daily waterpipe smokers, and its correlation with puff topography parameters. Sixty-one waterpipe tobacco smokers (56 males; mean age ± SD, 30.9 ± 9.5. years; mean number of weekly waterpipe smoking episodes 7.8 ± 5.7) abstained from smoking for at least 24. h, and then smoked tobacco from a waterpipe ad libitum in a laboratory setting. During the session puff topography parameters were monitored continuously, and pre- and post-smoking expired-air CO was measured. Before and after smoking, venous blood was sampled for the assessment of plasma nicotine using Gas Chromatography-Mass Spectrometry. The average pre- and post-smoking expired-air CO was 4 ± 1.7 and 35.5 ± 32.7. ppm, respectively (i.e., a CO boost of 31.5. ppm, p .001). Mean plasma nicotine concentration increased from 3.07 ± 3.05. ng-ml pre-smoking to 15.7 ± 8.7. ng-ml post-smoking (p .001). Plasma nicotine boost was correlated with total session time (Pearson correlation coefficient r = .31, p=.04), cumulative puff duration (r = .37, p = .01), mean puff duration (r = .34, p = .02), and total smoke inhaled in the session (r = .34, p = .02. These data show considerable nicotine exposure in daily waterpipe smokers, and that nicotine exposure is a function of waterpipe smoking patterns. © 2010 Elsevier Ltd.Akl EA, 2010, INT J EPIDEMIOL, V39, P834, DOI 10.1093-ije-dyq002; Asfar T, 2005, BMC PUBLIC HEALTH, V5, DOI 10.1186-1471-2458-5-19; Bacha Zeina Aoun, 2007, Inhal Toxicol, V19, P771, DOI 10.1080-08958370701401699; Cobb C, 2010, AM J HEALTH BEHAV, V34, P275; Eissenberg T, 2009, AM J PREV MED, V37, P518, DOI 10.1016-j.amepre.2009.07.014; Kim I, 2006, J MASS SPECTROM, V41, P815, DOI 10.1002-jms.1039; Maziak W, 2009, NICOTINE TOB RES, V11, P806, DOI 10.1093-ntr-ntp066; Maziak W, 2008, ADDICTION, V103, P1763, DOI 10.1111-j.1360-0443.2008.02327.x; Monzer B, 2008, FOOD CHEM TOXICOL, V46, P2991, DOI 10.1016-j.fct.2008.05.031; Salameh P, 2008, NICOTINE TOB RES, V10, P149, DOI 10.1080-14622200701767753; Shafagoj YA, 2002, INT J CLIN PHARM TH, V40, P249; Shihadeh A, 2004, PHARMACOL BIOCHEM BE, V79, P75, DOI 10.1016-j.pbb.2004.06.005; Shihadeh A, 2005, BEHAV RES METHODS, V37, P186, DOI 10.3758-BF03206414; Smith-Simone S, 2008, NICOTINE TOB RES, V10, P393, DOI 10.1080-14622200701825023; Ward KD, 2006, PREV MED, V43, P92, DOI 10.1016-j.ypmed.2006.03.010; Warren Charles W, 2009, Glob Health Promot, V16, P38, DOI 10.1177-175797590934219214202

    A Review of Some Updates in the 13th Edition of “Sears and Zemansky’s University Physics with Modern Physics” (Authors: Hugh D. Young and Roger A. Freedman; contributing author, A. Lewis Ford; 2012)

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    Young, H.D.; and Freedman, R.A.; Ford, A.L. (contributing author). 2012. Sears and Zemansky’s University Physics with Modern Physics. 13th ed.Pearson Education, Inc., Addison-Wesley, San Francisco, CA, USA

    Chemical composition of size-resolved particulate matter at near-freeway and urban background sites in the greater Beirut area

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    To characterize road-traffic emissions in the greater Beirut area, size-resolved PM10-2.5, PM2.5-0.25 and PM0.25 samples were concurrently collected at near-freeway and background sites. While particle mass levels were 1.3-2.6 times greater at the roadside than background location, PM10-2.5 and PM0.25 prevailed at both sites (36-43percent of PM10). A chemical mass closure showed that PM10-2.5 was mostly composed of crustal material, contributing to 12-23percent of its mass across sites. On the other hand, in PM2.5-0.25 and PM0.25, organic matter (46-56percent) was dominant at the roadside location, while secondary ions (SI, 54-68percent) were more abundant at the background site. In the vicinity of the freeway, organic carbon (OC) levels varied from 4μgm-3 in PM10-2.5 to 10.1μgm-3 in PM0.25, exceeding those at the background site by 4-7 times. In contrast, OC was largely water-soluble at the background location, with its water-soluble fraction displaying comparable PM2.5-0.25- and PM0.25-concentrations at both sites, corroborating its regional secondary origin. PM0.25-elemental carbon (EC), which dominated overall EC mass, was 7-fold greater at the near-freeway than background location, indicating a contribution from diesel or also smoking vehicles to road-traffic emissions. PM2.5-SI showed fairly uniform concentrations across sites, confirming their mainly regional source. Polycyclic aromatic hydrocarbons (PAHs) were undetected at the coastal background site, whereas their levels peaked at 11.5ngm-3 in proximity to the freeway, with the majority confined to PM0.25. Compared to other roadways, organic compounds at the freeway location exhibited high hopanes plus steranes-to-total carbon ratios (0.16-1.1ngμg-1), indicative of different engine configurations, fleet or also lubricating oil formulation. At both locations, PM0.25-bound n-alkanes (C19-C34) showed a predominance of high molecular weight homologues and no carbon number preference, suggesting their likely road dust source. Findings of this work indicate that ambient particles at the urban background site in Beirut are mainly of secondary origin and exist in significantly lower levels relative to PM at the roadside location. Particle emissions at the near-freeway site markedly exceed those measured at roadways in similar areas in the U.S. with comparable meteorology and geomorphology. 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    Development of an advanced absorption heat transformer

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    Mechanical Maritime and Materials Engineerin

    Thermal energy storage by means of an absorption cycle

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    Mechanical Maritime and Materials Engineerin
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