2,348 research outputs found
Leading chiral logarithms of KS→γγ and KS→γl+l− at two loops
No full textAbstractWe obtain the leading divergences at two-loop order for the decays KS→γγ and KS→γl+l− using only one-loop diagrams. We then find the double chiral logarithmic corrections to the decay branching ratio of KS→γγ and to the decay rate for KS→γl+l−. It turns out that these effects are numerically small and therefore make a very small enhancement on the branching ratio and decay rate. We also derive an expression for the corrections of type logμ×LEC. Numerical analysis done for the process KS→γγ shows that these single logarithmic effects can be sizable but come with opposite signs with respect to the double chiral logarithms
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No full textParticle collision statistics in turbulent flows with kinematic simulation
No full textColliding droplets or particles in turbulent flows are important in applications ranging from rain formation in clouds to aerosol production in process engineering. To reduce the computational costs when simulating such flows, kinematic simulation (KS) is frequently applied as a cheap surrogate for direct numerical simulation (DNS) of the turbulent flow field. In this work, we provide for the first time a systematic validation of the particle collision statistics that result from KS. We show that while the particle collision frequencies for particles with different Stokes numbers are in good agreement with DNS reference data, a more detailed inspection of the flow field and particle concentration characteristics reveals significant differences between KS and DNS
Wychowanie człowieka uczciwego jako społeczna misja Kościoła w myśli błogosławionego ks. Bronisława Markiewicza (1842–1912)
Full text linkEducation to honesty should be based on giving a good example by Catholics, building organizations and associations, which in practice would take joint responsibility for public life. The church was and is a teacher of society. The article aims to show some aspects of the Church’s responsibility in the education of the society to honesty on the example of Blessed Fr. Bronisław Markiewicz. Fr. Markiewicz knew that the witness of Christian life has enormous power and is able to rebuild whole societies. The author shows in his article that religion – according to Fr. B. Markiewicz - is a value that fosters integrity, motivates and enriches the human personality, leading the way and directions for universal and fundamental values , including patriotic and civic ones.Wychowanie do uczciwości powinno polegać na dawaniu przez katolików dobrego przykładu, budowaniu organizacji i stowarzyszeń, które w praktyce podjęłyby współodpowiedzialność za życie publiczne. Kościół był i jest nauczycielem społeczeństwa. Niniejszy artykuł ma na celu pokazanie niektórych aspektów tej współodpowiedzialności Kościoła za wychowanie społeczeństwa do uczciwości na przykładzie działalności błogosławionego ks. Bronisława Markiewicza. Ks. Markiewicz wiedział, że świadectwo życia chrześcijańskiego ma ogromną siłę i jest w stanie przebudować całe społeczeństwa. Autor pokazuje w swoim artykule, iż religia – według ks. B. Markiewicza – jest wartością, która wychowuje do uczciwości, motywuje i ubogaca osobowość człowieka, wyznacza drogę, kierunki dla wartości uniwersalnych i podstawowych, w tym także patriotycznych i obywatelskich
Time-varying characteristics of saturated hydraulic conductivity in grassed swales based on the ensemble Kalman filter algorithm: A case study of two long-running swales in Netherlands
No full textSaturated hydraulic conductivity (Ks) of the filler layer in grassed swales are varying in the changing environment. In most of the hydrological models, Ks is assumed as constant or decrease with a clogging factor. However, the Ks measured on site cannot be the input of the hydrological model directly. Therefore, in this study, an Ensemble Kalman Filter (EnKF) based approach was carried out to estimate the Ks of the whole systems in two monitored grassed swales at Enschede and Utrecht, the Netherlands. The relationship between Ks and possible influencing factors (antecedent dry period, temperature, rainfall, rainfall duration, total rainfall and seasonal factors) were studied and a Multivariate nonlinear function was established to optimize the hydrological model. The results revealed that the EnKF method was satisfying in the Ks estimation, which showed a notable decrease after long-term operation, but revealed a recovery in summer and winter. After the addition of Multivariate nonlinear function of the Ks into hydrological model, 63.8% of the predicted results were optimized among the validation events, and compared with constant Ks. A sensitivity analysis revealed that the effect of each influencing factors on the Ks varies depending on the type of grassed swale. However, these findings require further investigation and data support.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Hydraulic Structures and Flood RiskUrban Desig
Development of a cross-conjugated vinylogous [4+2] anionic annulation and application to the total synthesis of natural antibiotic (±)-ABX
No full text[[abstract]]The cross-conjugated vinylogous [4+2] anionic annulation has been newly developed, the cascade process of which has a high preference for regiochemical control and chemoselectivity, giving rise to exclusively Michael-type adducts in moderate to high yields (up to 94%, 35 examples). By making use of this approach as a key operation, the first total synthesis of natural antibiotic ABX, in racemic form, has been successfully achieved in a concise 7-step sequence with an overall yield of ca. 20%
Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression
Full text linkThis is the author accepted manuscript. The final version is available from the American Physiological Society via the DOI in this recordThe physiological role of the shorter isoform of WNK1 that is exclusively expressed in the kidney (KS-WNK1), with particular abundance in the distal convoluted tubule, remains elusive. KS-WNK1 despite lacking the kinase domain, is nevertheless capable of stimulating the NaCl cotransporter (NCC), apparently through activation of WNK4. It has recently been shown that a less severe form of the Familial Hyperkalemic Hypertension featuring only hyperkalemia is caused by missense mutations in the WNK1 acidic domain that preferentially affect CUL3-KLHL3 E3-induced degradation of KS-WNK1, rather than that of the full-length WNK1 (L-WNK1). Here we show that L-WNK1 is indeed less impacted by the CUL3-KLHL3 E3 ligase complex compared to KS-WNK1. We demonstrate that the unique 30 amino acid amino N-terminal fragment of KS-WNK1 is essential for its activating effect on NCC and recognition by KLHL3. We identify specific amino acid residues in this region critical for the functional effect of KS-WNK1 and KLHL3 sensitivity. To further explore this, we generated KLHL3-R528H knock-in mice that mimic human mutations causing Familial Hyperkalemic Hypertension. These mice revealed that the KLHL3 mutation specifically increased expression of KS-WNK1 in the kidney. We also observed that in wild type mice, expression of KS-WNK1 is only detectable after exposure to low potassium diet. These findings provide new insights into the regulation and function of KS-WNK1 by the CUL3-KLHL3 complex in DCT and indicate that this pathway is regulated by dietary K+ levels.National Institutes of Health (NIH)Conacyt MexicoPAPIIT UNAML'OréalMedical Research Council (MRC
Development of a cross-conjugated vinylogous [4+2] anionic annulation and application to the total synthesis of natural antibiotic (±)-ABX
No full text[[abstract]]The cross-conjugated vinylogous [4+2] anionic annulation has been newly developed, the cascade process of which has a high preference for regiochemical control and chemoselectivity, giving rise to exclusively Michael-type adducts in moderate to high yields (up to 94%, 35 examples). By making use of this approach as a key operation, the first total synthesis of natural antibiotic ABX, in racemic form, has been successfully achieved in a concise 7-step sequence with an overall yield of about 20%
Anionic diels-alder chemistry of cyclic sodium dien-1-olates delivering highly stereoselective and functionalized polycyclic adducts
No full text[[abstract]]Anionic Diels-Alder chemistry of electron-deficient cross-conjugated vinylogous alkenones, providing highly stable sodium dienolate ion pairs as electron-rich dienes in the presence of a weak sodium base in THF, has been newly developed, leading to a single Diels-Alder adduct, in racemic form, in moderate to high yields (up to 97%, 37 examples)
Direct numerical simulation of open-channel flow in the fully rough regime
No full textThe Direct Numerical Simulation (DNS) of an incompressible open channel flow over a layer of rigid spherical roughness elements fixed on the wall in well-packed square arrangement has been performed which shows values of the Reynolds number Rb ~ 6900 (ks+ ~ 100) and produces a mean velocity defect ∆U+ ~ 7 in the range of the fully-rough regime. First and second moment statistics of the velocity field have been analyzed. The stress distribution as well as the hydrodynamic force and torque acting on the surface of individual roughness elements have been computed. Results are presently shown and compared with those obtained in the context of a previous DNS performed in the transitionally rough regime
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