130 research outputs found
sj-docx-1-tdo-10.1177_00494755211068661 - Supplemental material for Cutaneous ulceration as a presenting feature of type 1 lepra reaction: A case report
No full textSupplemental material, sj-docx-1-tdo-10.1177_00494755211068661 for Cutaneous ulceration as a presenting feature of type 1 lepra reaction:
A case report by Pallavi Hegde, Deepti Jaiswal, Varsha M Shetty, Kanthilatha Pai and Raghavendra Rao in Tropical Doctor</p
The changing landscape of JIBS authorship
No full textIn this study, we examine the landscape of JIBS authorship over time to assess: (1) the accessibility of JIBS to new contributors, and (2) the diversity of authors contributing to JIBS. Our analysis of author data from 1972 to 2014 shows that JIBS is becoming more accessible, as indicated by the high and sustained proportion of first-time contributors to the journal. This is also evident from the recent decline in the share of authors with multiple past JIBS publications. With regard to diversity, our findings show that JIBS has a much wider geographic scope of authors on its landscape in comparison to previous decades. This may be attributed partly to increasing travel and communication in scholarly communities, and partly to the increased migration of scholars in the recent decades. Our analysis of migration patterns of JIBS authors suggests that about 51 % of prominent international business scholars are employed outside their country of birth. Of the 49 % employed in their country of birth, 12 % are return migrants. In our sample, China, South Korea and Canada have the highest number of returnees. The USA, the UK, Germany, the Netherlands and China have the highest number of natives, whose country of birth, country of PhD-granting institution and country of university affiliation are identical.Peer reviewe
A hierarchical spectral clustering and non-linear dimensionality reduction scheme for detection of prostate cancer from magnetic resonance spectroscopy:
No full textMagnetic Resonance Spectroscopy (MRS) is a unique non-invasive method which has recently been shown to have great potential in screening of prostate cancer (CaP). MRS provides functional information regarding the concentrations of different biochemicals present in the prostate at single or multiple locations within a rectangular grid of spectra superposed on the structural T2-weighted Magnetic Resonance Imaging (MRI). Changes in relative concentration of specific metabolites including choline, creatine and citrate compared to "normal" levels is highly indicative of the presence of CaP. Most previous attempts at developing computerized schemes for automated prostate cancer detection using MRS have been centered on developing peak area quantification algorithms. These methods seek to obtain area under peaks corresponding to choline, creatine and citrate which is then used to compute relative concentrations of these metabolites. However, manual identification of metabolite peaks on the MR spectra, let alone via automated algorithms, is a challenging problem on account of low SNR, baseline irregularity, peak-overlap, and peak distortion. In this thesis work a novel computer aided detection (CAD) scheme for prostate MRS is presented that integrates non-linear dimensionality reduction (NLDR) with an unsupervised hierarchical clustering algorithm to automatically identify cancerous spectra. The methodology comprises of two specific aims. Aim 1 is to first automatically localize the prostate region followed in Aim 2 by automated cancer detection on the prostate obtained in Aim 1. In Aim 1, a hierarchical spectral clustering algorithm is used to distinguish between informative and non-informative spectra in order to localize the region of interest (ROI) corresponding to the prostate. Once the prostate ROI is localized, in Aim 2, a non-linear dimensionality reduction (NLDR) scheme in conjunction with a replicated k-means clustering algorithm is used to automatically discriminate between 3 classes of spectra (normal, CaP, and intermediate tissue classes). Results of qualitative and quantitative evaluation of the methodology over 18 1.5 Tesla (T) in-vivo prostate T2-w and MRS studies obtained from the multi-site, multi-institutional ACRIN trial, for which corresponding histological ground truth of spatial extent of CaP is available, reveal that the CAD scheme has a high detection sensitivity (89.60) and specificity (78.98). Results further suggest that the CAD scheme has a higher detection accuracy compared to such commonly used MRS analysis schemes as z-score and PCA.M.S.Includes bibliographical references (p. 47-49).by Pallavi Tiwar
The effect of mechanical strain on properties of lubricated tablets compacted at different pressures
No full textA full factorial design of experiments was used to study the effect of blend shear strain on the compaction process, relative density and strength of pharmaceutical tablets. The powder blends were subjected to different shear strain levels (integral of shear rate with respect to time) using an ad hoc Couette shear cell. Tablets were compressed at different compaction forces using an instrumented compactor simulator, and compaction curves showing the force-displacement profiles during compaction were obtained. Although the die-fill blend porosity (initial porosity) and the minimum in-die tablet porosity (at maximum compaction) decreased significantly with shear strain, the final tablet porosity was surprisingly independent of shear strain. The increase in the in-die maximum compaction with shear strain was, in fact, compensated during post-compaction relaxation of the tables, which also increased significantly with shear strain. Therefore, tablet porosity alone was not sufficient to predict tablet tensile strength. A decrease in the ‘work of compaction’ as a function of shear strain, and an increase in the recovered elastic work was observed, which suggested weaker particle-particle bonding as the shear strain in- creased. For each shear strain level, the Ryskewitch Duckworth equation was a good fit to the tensile strength as a function of tablet porosity, and the obtained asymptotic tensile strength at zero porosity exhibited a 60% reduction as a function of shear strain. This was consistent with a reduced bonding efficiency as the shear strain increased.Peer reviewed
Quantitative integration of imaging and non-imaging data: application to integrating multi-parametric MRI for prostate cancer diagnosis, grading and treatment evaluation
No full textThe problem of data integration involving imaging and non-imaging modalities is largely unexplored in the biomedical eld, mainly due to the challenges in quantitatively combining such heterogeneous modalities existing in diff erent dimensions and scales. Although several methods have been proposed in the literature involving quantitative integration of multi-protocol imaging, there has been a paucity of similar biomedical tools for quantitative integration of imaging and non-imaging data. In this work, we present novel data integration schemes to overcome the aforementioned challenges limiting the integration of imaging and non-imaging modalities, and hence improve disease characterization. Our novel data integration methods are applied to integration of multi-parametric Magnetic Resonance (MR) imaging (MP-MRI)-structural MR imaging with metabolic spectroscopic information (non-imaging) for improved prostate cancer (CaP) diagnosis, grading, and treatment evaluation post-radiation therapy (RT). To this end, we have developed novel data integration schemes such as, Multimodal Wavelet Embedding Representation for data Combination (MaWERiC), and Semi-Supervised Multi-Kernel (SeSMiK) Graph Embedding, which fi rst uniformly represent individual data modalities into a common framework using dimensionality reduction and kernel embedding techniques, followed by a seamless integration of imaging and non-imaging data in the common framework. The integrated quantitative signatures thus obtained are shown to be signifi cantly more diagnostically informative as compared to any single modality. Similar improvement in results was observed using integrated MP-MRI signatures for evaluating radiation therapy related changes in CaP patients, with an aim to identify (a) pre-RT disease extent along with extra capsule spread (if any) and (b) residual disease on post-RT MP-MRI.Ph. D.Includes bibliographical referencesIncludes vitaby Pallavi Tiwar
D.H. Lawrence is the Harbinger of New Psycho Dynamics in the Modern Literature: Tyagi Pallavi
No full textThe psychodynamic model is founded on the ideas of Sigmund Freud. Freud’s writings have a greater influence on the development of psychology. Central to his approach is the assumption that biological drives and inborn instincts towards self-preservation direct behavior. Thus we are dominated by sexual and aggressive urges, catching the infant or young child in a crosscurrent. Though we are the mercy of our inherited urges and early parental training experiences, we survive by imposing rational control over these basic conflicts. Behavior that does not appear to make sense, or to be based on logic, is analyzed as a symptom of unconscious motives. According to psycho dynamic model, human nature is fully determined by heredity and early life experiences. In accordance of Freud’s belief, Lawrence as an author pours in his own unconscious into the characters and situations depicted in his works more specifically in his novels. Freudian interpretation of literature applied to Lawrence’s works becomes convincing and ingenious in explaining the “return of the repressed”. His novels besides portraying the psychology of characters are also taken as the conscious or ‘Overt’ interpretation of the ‘covert’ or the unconscious of the author himself. The critical analysis of the psycho dynamics revealing itself through abstract impulses, feelings, and instincts, mythical or materialistic symbols has been attempted in the present study
A hierarchical spectral clustering and nonlinear dimensionality reduction scheme for detection of prostate cancer from magnetic resonance spectroscopy (MRS)
No full textIn this article the authors present a novel CAD scheme that integrates nonlinear dimensionality reduction (NLDR) with an unsupervised hierarchical clustering algorithm to automatically identify suspicious regions on the prostate using MRS and hence avoids the need to explicitly identify metabolite peaks.The published version of this article is available at: http://scitation.aip.org/getpdf/servlet/GetPDFServlet?filetype=pdf&id=MPHYA6000036000009003927000001&idtype=cvips&prog=normalThis work was made possible via grants from the Wallace H. Coulter Foundation, New Jersey Commission on Cancer Research, National Cancer Institute (Grant Nos. R01CA136535-01, ARRA-NCl-3 R21CA127186–02S1, R21CA127186–01, and R03CA128081-01), the Society for Imaging Informatics in Medicine (SIIM), The Cancer Institute of New Jersey, and the Life Science Commercialization Award from Rutgers University
Afrindian Fictions: Diaspora, Race, and National Desire in South Africa
No full textIn the first published book-length study of Indian fiction in South Africa, Pallavi Rastogi demonstrates that Indians desire South African citizenship in the fullest sense of the word, a longing for inclusion that is asserted through an Afrindian identity. Afrindian Fictions: Diaspora, Race, and National Desire in South Africa examines Afrindian identity and blurs the racial binary of black and white interaction in South African studies as well as unsettles the East-West paradigm of migration dominant in South Asian diaspora studies.While offering incisive analyses of the work of the most important South African Indian writers today--Ahmed Essop, Farida Karodia, Achmat Dangor, Imraan Coovadia, and Praba Moodley among others--the author also places South African Indian fiction within broader literary traditions. Rastogi\u27s project of recovery shines a light on the rich but neglected literature by South African Indians. The book closes with interviews conducted with six key South African Indian writers. Here the authors not only reflect on their own writing but also comment on many of the issues raised in the book itself, particularly the role of Indians in South Africa today, and the status of South African Indian writing .Afrindian Fictions is a valuable introduction to South African Indian literature as well as a major interrogation of some of the foundational notions of post-colonial literary studies.https://repository.lsu.edu/facultybooks/1411/thumbnail.jp
Migrants and multinational firms: The role of institutional affinity and connectedness in FDI
No full textWe examine how, and to what extent, migrants in a host country attract foreign direct investment (FDI) from firms based in their country of origin (CO). Introducing the notion of institutional affinity, we argue that increased institutional affinity and increased connectedness of institutional environments of migrants’ CO and country of residence, make a location attractive to CO firms. Empirical analysis of FDI and migration panel data shows that in addition to the traditional factors influencing FDI patterns, there is a collective migrant effect on FDI, and this effect is statistically significant and economically meaningful for migrants from developing countries.Peer reviewe
The Biological Effects of Trauma
No full textIn this paper, we sought to understand the effects of trauma through a biological lens so that we could better learn how all the different expressions of mental unwellness, as a result of trauma, affect our everyday lives. Previous research has predicted that the symptomatic consequences of trauma can be identified and affected by variables such as platelet serotonin concentrations, substance addiction, and cortisol levels. For our correlational study, we tested the strength of these relationships by examining naturalistic daily changes in their variables over a one-week period. We measured substance addiction by how many alcoholic drinks were consumed each day, inferred cortisol levels by levels of water retention of the wrist each day, serotonin concentrations by rating tiredness each day using a subjective scale, and inferred traumatic symptoms by heart rate each day. Data pooled across participants in our correlational study showed that alcohol intake, but not serotonin or cortisol levels, was significantly correlated with our physiological measurement of trauma levels. Though a minute finding, this information may be able to offer guidance and aid to future psychologists and healthcare providers in both the furthering of their research and in the betterment of treatment plans for those who have undergone trauma. These findings could also motivate councillors and therapists to inaugurate more resources for combatting addiction into their practices.Supervising Instructor & Course Number: Michael Pollock, Psyc 215 (“Biological Psychology”
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