1,843 research outputs found
Comparative molecular genetics of the German Shepherd dog
No full textIncludes bibliographical references (leaves 105-111).Microsatellite markers were used to measure genetic diversity and population differentiation within and between domestic dog breeds. The German Shepherd Dog was compared with typical outbred mongrel dogs, Dachshunds, Staffordshire Bull Terriers and a cohort of other pedigreed dogs representing 30 recognised breeds. Although archaeological records report that grey wolves (Canis lupus) were domesticated approximately 14 000 years ago, mtDNA analysis suggests that domestic dogs (Canis familiaris) and grey wolves diverged in multiple events over 100 000 years ago. Subsequently, the movement of humans and their dogs resulted in extensive gene flow between dog populations for thousands of years. Breeding practices to obtain distinctive pnenotypic uniformity were recently introduced, resulting in pure-bred dogs becoming essentially closed gene pools. However, further mtDNA analyses have reported unexpectedly high levels of variability, supported by microsatellite loci with heterogeneities of between 36% and 55% being reported for some dog breeds. Microsatellite analyses of 15 polymorphic canine loci are reported. German Shepherd Dogs and outbred mongrel dogs expressed diversity values of 4.0 alleles per locus in the former and 6.4 in the later (corrected for population size by jack-knifing with 1 000 pseudoreplications), with expected heterozygosities of 62% and 83%, respectively. German Shepherd Dogs showed a moderate loss of genetic diversity relative to outbred dogs, but not sufficient to describe the breed as highly inbred. However, in comparison with other pure-bred dogs examined, they expressed the least genetic diversity, with Dachshunds having 5.2, Staffordshire Bull Terriers 4.8 and the composite group of pedigreed dogs 6.0 alleles per locus, with expected heterozygosities of 72%, 67% and 80%, respectively. Significant population differentiation (GST = 0.103; RST = 0.058) between German Shepherd Dogs and the outbred dogs illustrates the effect of genetic drift since the breed was established just over 100 years ago. This study would benefit future breeding programs, as management should be facilitated by knowledge of relative measures of inbreeding and differentiation, especially between various separate breeding stocks within the breed
La politica della legalità : il ruolo del giurista nell'età contemporanea
No full textAs the author of this book shows as he tests his theses, impartiality and justice require specific and scrupulous forms of civil engagement which render obsolete the traditional call for neutrality. At the same time, citizens must be made to understand how formal features of law that usually evoke their hostility actually guarantee their rights. The legal professional must learn to be a "relativist", obliged - through his choices - to establish priorities among distinct and often irreconcilable value domains
Cercando di dimenticare Savigny
No full textIl presente scritto è un contributo alla discussione del libro di Aurelio Gentili, Il
diritto come discorso del 2013. Del predetto volume si approvano senza riserve
a) la critica alla concezione del vecchio positivismo, secondo il quale il giurista
non farebbe altro che esplorare un misterioso oggetto denominato “realtà
giuridica”, e b) l’interesse per le tecniche argomentative quali strumenti di
controllo interno dei discorsi. Sul piano propositivo, l’autore della recensione
ammette che la conoscenza dei significati normativi letterali, quando la si
ritiene rilevante, comporta a livello collettivo (ma assai meno al livello dei
singoli) un giudizio partecipante. Tali significati, del resto, lungi dall’essere
entità fisse, sono sempre in movimento. Ciò stabilito e con questi limiti,
occorre ammettere che non c’è solo un ordo ordinans imposto dai giuristi sui
confusi materiali estratti dalle fonti, ma si può scorgere, e si deve ritrovare,
anche un ordo ordinatus, frutto tanto dell’attività legislativa quanto delle precedenti interpretazioni, che il singolo interprete non può far a meno di
riconoscere. Insomma: tra i due ordini, fra le attività dei giuristi e i prodotti di
tali attività, si stabilisce un rapporto dialettico.This article is a contribution to the discussion regarding Aurelio Gentili’s 2013
book Il diritto come discorso. From the said volume, the author fully approves:
a) the criticism of the old positivism’s conception that a lawyer does nothing
but explore the misterious object that is “legal reality”, and b) the interest in
argumentative techniques as instruments for internal control of discourses. The
author of this article proposes admitting that the knowledge of literal normative
meanings, when believed to be relevant, requires at the level of the collective
(much less so at the individual level) a judgment, which demonstrates
participation. These meanings are, moreover, far from being fixed entities,
always changing. Within these limits, it should be admitted that there is not
only an ordo ordinans, made by the jurists, using the confused materials
extracted from the sources, but that we may also observe, and must rediscover,
an ordo ordinatus, which results from both legislative activity and previous
interpretations – that an individual interpreter cannot but recognize. In short, a
dialectic relationship between the two orders, between the activity of lawyers
and the products of these activities, is thus established
Raising high-density lipoprotein cholesterol with reduction of cardiovascular risk: the role of nicotinic acid - a position paper developed by the European Consensus Panel on HDL-C
No full textReduction of low-density lipoprotein cholesterol (LDL-C) is presently the primary focus of lipid-lowering therapy for prevention and treatment of coronary heart disease (CHD). However, the high level of residual risk among statin-treated patients in recent coronary prevention studies indicates the need for modification of other major components of the atherogenic lipid profile. There is overwhelming evidence that a low plasma level of high-density lipoprotein cholesterol (HDL-C) is an important independent risk factor for CHD. Moreover, a substantial proportion of patients with or at risk of developing premature CHD typically exhibit distinct lipid abnormalities, including low HDL-C levels. Thus, therapeutic intervention aimed at raising HDL-C, within the context of reducing global cardiovascular risk, would benefit such patients, a viewpoint increasingly adopted by international treatment guidelines. Therapeutic options for patients with low HDL-C include treatment with statins, fibrates and nicotinic acid, either as monotherapy or in combination. Of these options, nicotinic acid is not only the most potent agent for raising HDL-C but is also effective in reducing key atherogenic lipid components including triglyceride-rich lipoproteins (mainly very low-density lipoproteins [VLDL] and VLDL remnants), LDL-C, and lipoprotein(a). The principal features of the atherogenic lipid profile in type 2 diabetes and the metabolic syndrome make them logical targets for nicotinic acid therapy, either alone or in combination with a statin. The lack of comprehensive European data on the prevalence of low HDL-C levels highlights a critical need for education on the importance of raising HDL-C in CHD prevention and treatment. The development of a reliable and accurate assay for HDL-C, as well as clarification of criteria for low and optimal levels of HDL-C in both men and women, constitute critical factors in the reliable identification and treatment of patients at elevated risk of CHD due to low HDL-C. Based on the available evidence, the European Consensus Panel recommends that the minimum target for HDL-C should be 40 mg/dL (1.03 mmol/L) in patients with CHD or with a high level of risk for CHD, including patients at high global risk with type 2 diabetes or the metabolic syndrome
Exact two-dimensionalization of low-magnetic-Reynolds-number flows subject to a strong magnetic field
No full textWe investigate the behavior of flows, including turbulent flows, driven by a horizontal body-force and subject to a vertical magnetic field, with the following question in mind: for very strong applied magnetic field, is the flow mostly two-dimensional, with remaining weak three-dimensional fluctuations, or does it become exactly 2D, with no dependence along the vertical? We restrict attention to low-magnetic-Reynolds number (Rm) flow. Because liquid metals have low magnetic Prandtl number, such low- flows can have a kinetic Reynolds number as large as one million and therefore be strongly turbulent. We first focus on the quasi-static approximation, i.e. the asymptotic limit of vanishing magnetic Reynolds number Rm << 1: we prove that the flow becomes exactly 2D asymptotically in time, regardless of the initial condition and provided the interaction parameter N is larger than a threshold value. We call this property absolute two-dimensionalization: the attractor of the system is necessarily a (possibly turbulent) 2D flow. We then consider the full-magnetohydrodynamic equations and we prove that, for low enough Rm and large enough N, the flow becomes exactly two-dimensional in the long-time limit provided the initial vertically-dependent perturbations are infinitesimal. We call this phenomenon linear two-dimensionalization: the (possibly turbulent) 2D flow is an attractor of the dynamics, but it is not necessarily the only attractor of the system. Some 3D attractors may also exist and be attained for strong enough initial 3D perturbations. These results shed some light on the existence of a dissipative anomaly for magnetohydrodynamic flows subject to a strong external magnetic field
Letter from Lee C.R. Baker, Reference Assistant to Michi Weglyn, September 25, 1974
No full textThis letter refers to a thesis written by Warren Page Rucker in 1970 entitled, "United States--Peruvian Policy Toward Peruvian-Japanese Persons During World War II." Baker explains that Weglyn can purchase a copy of the thesis if she so desires.Collection of notes, articles, correspondence, photographs, and term papers collected by Yukio Mochizuki, a student at CSU Dominguez Hills, while researching Japanese American incarceration and Japanese Peruvian internment during World War II
Flow instabilities and reversals in non-uniformly thermocapillary driven melt pool
No full textWith transient LES and DNS simulations, we investigate flow in melt pools driven by thermocapillary forces. The developing pool is at first axisymmetric as are the boundary conditions, but flow instabilities arise that lead to 3D oscillatory flow patterns. At higher laser powers a sign-change in the surface tension temperature coefficient occurs, resulting in a flow reversal in the pool and thus two counter-rotating vortices, which exhibit similar though more complex flow instabilities
Shepherd, Sevy
No full textPhotograph from the C.R. Savage Portrait Studio. Name associated with the photograph: Sevy Shepher
Shepherd, Alvin
No full textPhotograph from the C.R. Savage Portrait Studio. Name associated with the photograph: Alvin Shepher
Shepherd, Ray
No full textPhotograph from the C.R. Savage Portrait Studio. Name associated with the photograph: Ray Shepher
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