6,058 research outputs found
Replication Data for: Nearly ferromagnetic spin-triplet superconductivity
No full textReplication Data for: Nearly ferromagnetic spin-triplet superconductivit
Replication Data for: Nearly ferromagnetic spin-triplet superconductivity
No full textReplication Data for: Nearly ferromagnetic spin-triplet superconductivit
On the opportunistic topology of taxi networks in urban mobility environment
No full textUnderstanding and characterizing the connectivity of vehicular networks has become increasingly important because of their wide applications and fast development. To address the dynamical links in vehicular networks, time-varying graph (TVG) is one of the most important models. Nowadays, due to the fact that lots of vehicular applications can tolerate a small amount of latency in communication, opportunistic reachability graph (ORG) characterizes the connectivity better by introducing delay tolerance to the model. However, people still do not have a high-level summarization, i.e. the topology, of the vehicular network on how nodes are clustered and isolated. In this paper, based on ORG model, we analyze the opportunistic topology of taxi networks in urban mobility environment by mainly focusing on the number, location and evolution of connected components and the size of the largest components to reveal the unique properties of the taxi networks instead of just links and hops. Our analysis is based on the real taxi traces of big cities and reflects the real urban mobility environment. We find that the opportunistic topology of the networks with delay tolerance is substantially different from the instantaneous topology without considering the delay. Moreover, we unveil the fundamental relationships and trade-offs between the dynamical topology and the key network parameters related to mobility, e.g., delay tolerance, transmission distance, etc. To the best of our knowledge, our study is the first work to reveal the characteristics of opportunistic topology models in the large-scale urban mobility environment with real traces
Variations of care quality for infectious pulmonary tuberculosis in Taiwan: a population based cohort study
No full textPaper-based N-doped carbon films for enhanced oxygen evolution electrocatalysis
No full textCellulous-fiber papers are used as 3D structural templates for the assembly of graphene and graphitic carbon nitrate (g-C₃N₄) ultrathin nanosheets. The resultant materials, which possess highly active centers, rich porosity, and 3D conductive networks, can catalyze the oxygen evolution reaction with competitive activity and much better durability compared to the benchmark noble metal electrocatalysts (IrO₂).Sheng Chen , Jingjing Duan , Jinrun Ran , and Shi-Zhang Qia
Functional Blockade of Small GTPase RAN Inhibits Glioblastoma Cell Viability
No full textGlioblastoma, the most common malignant tumor in the brain, lacks effective treatments and is currently incurable. To identify novel drug targets for this deadly cancer, the publicly available results of RNA interference screens from the Project Achilles database were analyzed. Ten candidate genes were identified as survival genes in 15 glioblastoma cell lines. RAN, member RAS oncogene family (RAN) was expressed in glioblastoma at the highest level among all candidates based upon cDNA microarray data. However, Kaplan-Meier survival analysis did not show any correlation between RAN mRNA levels and patient survival. Because RAN is a small GTPase that regulates nuclear transport controlled by karyopherin subunit beta 1 (KPNB1), RAN was further analyzed together with KPNB1. Indeed, GBM patients with high levels of RAN also had more KPNB1 and levels of KPNB1 alone did not relate to patient prognosis. Through a Cox multivariate analysis, GBM patients with high levels of RAN and KPNB1 showed significantly shorter life expectancy when temozolomide and promotermethylation of O6-methylguanine DNA methyltransferase were used as covariates. These results indicate that RAN and KPNB1 together are associated with drug resistance and GBM poor prognosis. Furthermore, the functional blockade of RAN and KPNB1 by importazole remarkably suppressed cell viability and activated apoptosis in GBM cells expressing high levels of RAN, while having a limited effect on astrocytes and GBM cells with undetectable RAN. Together, our results demonstrate that RAN activity is important for GBM survival and the functional blockade of RAN/KPNB1 is an appealing therapeutic approach.Roanoke Valley Governor Schoo
Effects of substitution on low-temperature physical properties of LuFe<sub>2</sub>Ge<sub>2</sub>
No full textThe low-temperature magnetic phase transition in LuFe2Ge2 is thought to be associated with itinerant magnetism. The effects of Y and Sc substitutions on the Lu site, as well as Ru and Co substitutions on the Fe site, on the low-temperature magnetic phase transition of the LuFe2Ge2 compound have been studied in single crystals via microscopic, thermodynamic and transport measurements. On one hand, Co substitution suppresses the transition below our base temperature of 2 K even at our lowest substitution level. On the other hand, Sc substitution enhances the transition temperature, and Y or Ru substitution suppresses the transition to lower temperature. Phase diagrams for Y, Sc and Ru substitutions have been constructed and the possibility of a unifying, composite diagram is discussed.This article is published by Taylor & Francis as Ran, Sheng, Sergey L. Bud'ko, and Paul C. Canfield. "Effects of substitution on low-temperature physical properties of LuFe2Ge2." Philosophical Magazine 91, no. 34 (2011): 4388-4400. DOI: 10.1080/14786435.2011.621903.</p
Functional Blockade of Small GTPase RAN Inhibits Glioblastoma Cell Viability
No full textGlioblastoma, the most common malignant tumor in the brain, lacks effective treatments and is currently incurable. To identify novel drug targets for this deadly cancer, the publicly available results of RNA interference screens from the Project Achilles database were analyzed. Ten candidate genes were identified as survival genes in 15 glioblastoma cell lines. RAN, member RAS oncogene family (RAN) was expressed in glioblastoma at the highest level among all candidates based upon cDNA microarray data. However, Kaplan-Meier survival analysis did not show any correlation between RAN mRNA levels and patient survival. Because RAN is a small GTPase that regulates nuclear transport controlled by karyopherin subunit beta 1 (KPNB1), RAN was further analyzed together with KPNB1. Indeed, GBM patients with high levels of RAN also had more KPNB1 and levels of KPNB1 alone did not relate to patient prognosis. Through a Cox multivariate analysis, GBM patients with high levels of RAN and KPNB1 showed significantly shorter life expectancy when temozolomide and promoter methylation of O6-methylguanine DNA methyltransferase were used as covariates. These results indicate that RAN and KPNB1 together are associated with drug resistance and GBM poor prognosis. Furthermore, the functional blockade of RAN and KPNB1 by importazole remarkably suppressed cell viability and activated apoptosis in GBM cells expressing high levels of RAN, while having a limited effect on astrocytes and GBM cells with undetectable RAN. Together, our results demonstrate that RAN activity is important for GBM survival and the functional blockade of RAN/KPNB1 is an appealing therapeutic approach
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