960 research outputs found
Optimal design of building integrated energy systems by combining two-phase optimization and a data-driven model
No full textBy combining renewable energy systems (RESs) with buildings, building integrated energy systems (BIESs) reshape the building demand-supply relationship and contribute to both embodied and operational benefits. Their optimal designs, however, require consideration of various parameters and model complexity, making it challenging to solve multi-criteria problems and computationally intensive. This study aims to develop a datadriven two-phase optimization framework for exploring optimal BIES configurations. The novelties lie in 1) a co-simulation modelling and evaluation framework for BIES from both building and RES perspectives; 2) a twophase workflow to decouple the complex BIES model and solve multi-criteria decision problems and 3) an artificial neural network (ANN) surrogate model for rapid prediction. The proposed method is demonstrated using a prototype office building in a hot-summer and cold-winter area of China. The results show that RES-only optimization presents the lowest performances, necessitating the coordinated design for both building and RES sides. The simultaneous optimization method demonstrates the balanced quality for exploring both Pareto front and optimal solution, but encounters expensive computational costs (225 h) and convergence difficulty under 5000 optimization iterations. Comparatively, the proposed ANN-based two-phase optimization can achieve competitive solutions with half the computational time (90.6 h), which can be further reduced by efficient sampling methods. Overall, this study provides an optimization framework for holistically assessing and designing BIES that can approximate optimal configurations with significant computational savings
Bu-Shen-Ning-Xin Decoction ameliorated the osteoporotic phenotype of ovariectomized mice without affecting the serum estrogen concentration or uterus
No full textLing Wang,1,2,* Xue-Min Qiu,1,2,* Yu-Yan Gui,1,2 Ying-Ping Xu,1,2 Hans-Jürgen Gober,3 Da-Jin Li1 1Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, IBS, Fudan University Shanghai Medical College, 2Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, People’s Republic of China; 3Department of Pharmacy, Wagner Jauregg Hospital and Children’s Hospital, Linz, Austria *These authors contributed equally to this work Introduction: Bu-Shen-Ning-Xin Decoction (BSNXD), a traditional Chinese medicinal composition, has been used as a remedy for postmenopausal osteoporosis, but its effects on bone metabolism and the uterus have not been reported.Purpose: We aimed to determine the respective effects of BSNXD on the bones and the uterus of ovariectomized (OVX) mice to evaluate the efficacy and safety of this herbal formula.Materials and methods: Postmenopausal osteoporosis animal models that were generated by ovariectomy were treated with BSNXD. Dual-energy X-ray absorptiometry was performed to analyze the bone mineral density, and histomorphometric analysis was performed to measure the parameters related to bone metabolism. Calcein labeling was performed to detect bone formation. The uteruses from the mice were weighed, and the histomorphometry was analyzed. Drug-derived serum was prepared to assess the 17-β-estradiol concentration via enzyme immunoassay.Results: BSNXD administration ameliorated the osteoporotic phenotype of OVX mice, as evidenced by an increase in the bone mineral density and bone volume; these effects could not be abolished by the administration of the aromatase inhibitor letrozole. Moreover, BSNXD had no effect on the serum estrogen concentration or uterus.Conclusion: These results suggest that BSNXD has ameliorating effects on bone loss due to estrogen deprivation without affecting the peripheral blood estrogen concentration or the uterus in OVX mice. Keywords: traditional Chinese medicine, postmenopausal osteoporosis, OVX, bone phenotype, estrogen 
Laser-induced fluorescence microscopy - application to possible high rank and carbonate source rocks
No full textCANONICAL ABERRATION THEORY IN ELECTROMAGNETIC MULTIPOLES
No full textIn a 2N-pole electromagnetic system, defining the electron optical Hamiltonian function, we have derived both general algebraic expressions (arbitrary N) and special numerical formulas (N = 3,4,5,6,7) for different aberrations from lower to higher order (i.e., the order of N - 1, N + 1, 2N - 3, 2N - 1, 3N - 5). The so-called canonical aberration theory in electromagnetic multipoles has thus been developed, which allows us to deduce angular dependencies of different aberrations and to examine the possibility for spherical correction of a round lens by using multipoles.Physics, AppliedSCI(E)0ARTICLE125968-59756
Asymmetric cyanosilylation of ketones catalyzed by chiral N-oxide-titanium (IV) complex
No full textA new approach for the asymmetric addition of trimethylsilylcyanide to ketones using chiral N-oxide-Ti(iPrO)(4) Complex as catalyst is reported, The screening of a number of chiral N-oxides has resulted in a system that lives the O-TMS ethers of cyanohydrins in good isolated yields with enantiomeric excesses of up to 69%
Bu-Shen-Ning-Xin decoction: inhibition of osteoclastogenesis by abrogation of the RANKL-induced NFATc1 and NF-κB signaling pathways via selective estrogen receptor α
No full textLing Wang,1,2,* Xue-Min Qiu,1,2,* Yu-Yan Gui,1,2 Ying-Ping Xu,1,2 Hans-Jürgen Gober,3 Da-Jin Li11Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, IBS, Fudan University Shanghai Medical College, 2Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, People’s Republic of China; 3Department of Pharmacy, Wagner Jauregg Hospital and Children’s Hospital, Wagner Jauregg Weg, Linz, Austria*These authors contributed equally to this workIntroduction: Bu-Shen-Ning-Xin decoction (BSNXD) is a traditional Chinese medicinal composition that has been used as a remedy for postmenopausal osteoporosis, but the mechanisms affecting bone metabolism are not fully understood.Purpose: We investigated the molecular mechanism and signaling pathway underlying the effect of BSNXD on osteoclastogenesis.Materials and methods: A postmenopausal osteoporosis animal model generated by ovariectomy was administered BSNXD and drug-derived serum was prepared. An enzyme immunoassay was conducted to measure the 17-β-estradiol (E2) concentration in the drug-derived serum. Bone marrow-derived monocyte/macrophage precursor cells were treated with drug-derived serum, and tartrate-resistance acid phosphatase staining was conducted to observe osteoclastogenesis. A bone resorption assay was performed to analyze the effect on osteoclastic resorptive function. Real-time PCR, flow cytometry, Western blotting, transfection, and luciferase assays were conducted to explore the related mechanism.Results: E2 was not elevated in BSNXD-derived serum. BSNXD-derived serum suppressed receptor activation of nuclear factor κB ligand (RANKL)-activated osteoclastogenesis in a dose-dependent manner; this effect could be reversed by estrogen receptor α antagonist methyl-piperidino-pyrazole. The serum suppressed RANKL-induced NF-κB transcription and inhibited the accumulation of nuclear factor of activated T-cells, cytoplasmic 1 in osteoclast precursor cells; the inhibitory effect was abolished by methyl-piperidino-pyrazole but not the estrogen receptor β antagonist or androgen receptor antagonist.Conclusion: These results collectively suggest that administration of BSNXD presents inhibitory effects on osteoclast differentiation by abrogating the RANKL-induced nuclear factor of activated T-cells, cytoplasmic 1 and NF-κB signaling pathways downstream of estrogen receptor α, thereby contributing to the inhibitory effect on bone resorption.Keywords: herbal formula, osteoclastogenesis, estrogen receptor α, NF-κB, NFATc
Observation of hydrocarbon generation and migration of highly-matured carbonates by means of laser-induced fluorescence microscopy
No full text
- …
