56,902 research outputs found
Nur-i-Afshan V.03 no.25 June 1899 Supplement
No full textContents: Editorial notes - Current thought : living up to rule by Sheldon, Charles M., 1857-1946 - Suggestive thoughts from the writings of Reverend Andrew Murray - The secret of his presence [Poetry] by Goreh, Ellen Lakshmi - Telegrams [Letter]
This volume of Nur-i-Afshan published weekly on Fridays from Ludhiana
Protective role of the dynamin inhibitor Dynasore against the cholesterol-dependent cytolysin of Trueperella pyogenes
No full textThe virulence of many Gram-positive bacteria depends on cholesterol-dependent cytolysins (CDCs), which form pores in eukaryotic cell plasma membranes. Pyolysin (PLO) from Trueperella pyogenes provided a unique opportunity to explore cellular responses to CDCs because it does not require thiol activation. Sublytic concentrations of PLO stimulated phosphorylation of MAPK ERK and p38 in primary stromal cells, and induced autophagy as determined by protein light-chain 3B cleavage. Although, inhibitors of MAPK or autophagy did not affect PLO-induced cytolysis. However, 10 μM 3-hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide (Dynasore), a dynamin guanosine 5′-triphosphatase inhibitor, protected stromal cells against PLO-induced cytolysis as determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (85 ± 17% versus 50 ± 9% cell viability), measuring extracellular ATP, and kinetic assays. This was a generalized mechanism because Dynasore also protected HeLa cells against streptolysin O. Furthermore, the effect was reversible, with stromal cell sensitivity to PLO restored within 30 minutes of Dynasore removal. The protective effect of Dynasore was not conferred by dynamin inhibition, induction of ERK phosphorylation, or Dynasore binding to PLO. Rather, Dynasore reduced cellular cholesterol and disrupted plasma membrane lipid rafts, similar to positive control methyl-β-cyclodextrin. Dynasore is a tractable tool to explore the complexity of cholesterol homeostasis in eukaryotic cells and to develop strategies to counter CDCs.—Preta, G., Lotti, V., Cronin, J. G., and Sheldon, I. M. Protective role of the dynamin inhibitor Dynasore against the cholesterol-dependent cytolysin of Trueperella pyogenes
World War I record of service survey for Ford M. Thomas, signed 30 December 1924
No full textQuestionnaire about Ford M. Thomas's service in World War I, 1917-1919, signed by Thomas 23 September 1922.Questionnaire originally part of a survey of Norwich University alumni conducted in 1922; fire damage most likely a result of the Dewey Hall Fire in 1925. Data from these questionnaires was used in a chapter of "Vermont in the world war, 1917-1919" by Harold P. Sheldon (1928). Transcription by Grey Ocreto. Transcriptions may be subject to error
\u3ci\u3eFollowing In His Steps: A Biography of Charles M. Sheldon\u3c/i\u3e by Timothy Miller (Review)
No full textReview of the book Following In His Steps: A Biography of Charles M. Sheldon by Timothy Miller
Death in the city: mortuary archaeology to 1800
No full textBook synopsis: London's archaeology is as complex and varied as the city is today. These seventeen papers survey twenty-five years of London archaeology in the city and its environs from prehistory to 1800. Contents: Introduction ( H Sheldon and I Haynes ); Towards the development of a settled landscape in London c.4000-1200 BC ( J Cotton ); Changing approaches to the first milolennium ( N Merriman ); The Roman city ( M Hassall ); Art in Roman London ( M Henig ); Religion ( I Haynes ); Evidence from Roman London's cemeteries ( B Barber and J Hall ); Roman Southwark ( H Sheldon ); Roads, roadside settlements and their countryside ( D G Bird ); Early and middle Saxon archaeology ( R Cowie ); Late Saxon and Norman London ( J Clark ); Buildings and defences 1200-1600 ( J Schofield ); Medieval pottery ( A Vince ); Tudor and Stuart playhouses ( S Blatherwick ); Morturay archaeology to 1800 ( V Harding ); Environmental archaeology ( J Sidell ); Archaeology of London, 1973-1997 ( R Cowie and R Densem )
World War I record of service survey for Richard M. Parker, signed 28 March 1926.
No full textQuestionnaire about Richard McKenzie Parker's service in World War I, 1917-1919, signed by Parker on 28 March 1926.Questionnaire originally part of a survey of Norwich University alumni conducted by a “Norwich in the World War” committee consisting of Charles N. Barber (chairman), Carl V. Woodbury, K.R.B. Flint, and Gustaf A. Nelson. Data from these questionnaires may have been used in a chapter of "Vermont in the world war, 1917-1919" by Harold P. Sheldon (1928)
Sheldon Wolin e l’elitarismo come sovversione della democrazia
No full textSheldon Wolin (1922-2015) è tra i maggiori studiosi della crisi della democrazia contemporanea, che approfondisce in chiave storica e teorica con particolare attenzione rispetto all'esperienza americana, individuandovi le dinamiche politiche tipiche dell'elitarismo attraverso l'approfondimento dell’opposizione tra i «Pochi» e i «Più» come via di accesso ai posti di comando del potere politico
A CROSS-SECTION ANALYSIS OF INTRA-INDUSTRY TRADE IN THE U.S. PROCESSED FOOD AND BEVERAGE SECTORS
No full textThis paper analyzes the determinants of variation across industries in levels of intra-industry trade (IIT) for a sample of 36 U.S. processed food and beverage industries in 1987, previous studies of intra-industry trade having focused on industry characteristics in the manufacturing sectors. The determinants predicted by IIT theory are measures of product differentiation, economies of scale, and imperfect competition; the results of this analysis indicate that IIT variation across the food and beverage industries is positively related to product differentiation, U.S. total trade, similarity of tariff barriers among trade partners, and economies of scope, but negatively related to industry concentration.International Relations/Trade,
World War I record of service survey for Charles M. Hughes, signed 9 March 1926.
No full textQuestionnaire about Charles Maurice Hughes' service in World War I, 1917-1919, signed by Hughes on 9 March 1926.Questionnaire originally part of a survey of Norwich University alumni conducted by a “Norwich in the World War” committee consisting of Charles N. Barber (chairman), Carl V. Woodbury, K.R.B. Flint, and Gustaf A. Nelson. Data from these questionnaires may have been used in a chapter of "Vermont in the world war, 1917-1919" by Harold P. Sheldon (1928)
Phase I/II trial of bevacizumab and radiotherapy for locally advanced inoperable colorectal cancer: vasculature-independent radiosensitizing effect of bevacizumab.
No full textPURPOSE: Anti-vascular endothelial growth factor therapy enhances the activity of radiotherapy in experimental models, and bevacizumab has therapeutic activity in patients with metastatic colorectal cancer. EXPERIMENTAL DESIGN: Twenty-two patients with locally advanced inoperable colorectal carcinomas (LA/I-CRC) were treated with conformal hypofractionated (3.4 Gy/fraction x 15) split-course accelerated radiotherapy (biological equivalent dose, 67.2 Gy) supported with amifostine, capecitabine (600 mg/m2 daily, 5 days/week), and bevacizumab (5 mg/kg every 2 weeks, five cycles). Biopsies from nine patients, performed before and 1 week after bevacizumab administration, were analyzed for changes in mRNA expression with Illumina gene arrays. RESULTS: No serious grade 3 chemotherapy-related side effects were recorded. There was low acute toxicity, with moist perineal desquamation noted in 2 of 22 patients, diarrhea grade 2 to 3 in 5 of 22 patients, and severe proctalgia in 2 of 22 patients. One patient died from Fournier's gangrene before treatment completion. Within a median follow-up of 18 months, two patients with preradiotheraphy direct involvement of adjacent organs expressed recto-vaginal/perineal fistula. Out of 19 evaluable cases, 13 (68.5%) showed complete response and 4 showed (21.1%) partial response. Fourteen patients are alive with no evidence of loco-regional relapse. In the gene array analysis, 30 known genes associated with transcription factors, DNA repair, and proliferation were downregulated by bevacizumab. DUSP1 gene was the most consistently downregulated transcript. CONCLUSIONS: The combination of radiotherapy with bevacizumab is feasible and results in a high rate of durable complete responses in patients with LA/I-CRC. Radiosensitization may occur through a direct effect on tumor cells followed by a wide scale suppression of transcription factors and genes involved in DNA repair and proliferation
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