7 research outputs found
Information Communication Technolgy and Tax Administration in Kebbi State, Nigeria
No full textAdministration of tax laws and policies is the major source through which government around the world raise money to cater for the economic and social wellbeing of the citizenry, the same goes for Nigeria in general and Kebbi State in particular. However, due to the poor tax administration which is as a result of the inability of the Nigeria tax authorities to effectively and efficiently administer tax laws and policies, as such, governments are left with very insignificant tax revenue which undermine their effort in providing economic and social infrastructures to promote the condition of living of the people. The high level of poverty, unemployment, poor infrastructural development, growing public debt and over reliance on statutory allocation from the federation account are all attributed to poor tax administration due to the failure of tax authorities to collect all approved pubic revenue. Information Communication Technology adoption in taxpayers registration, filling of tax return, tax assessment and tax collection have the potential of improving tax administration and increasing tax revenue. It has been observed that, failure to deploy Information Communication Technology in tax administration has undermined the effort of Kebbi State Board of internal Revenue to collect all approved public revenue there by enabling large number of taxpayers to escape from the tax net, delay in filling of tax return, lead to errors and inaccuracies in tax assessment, which brings about high cost of tax collection, as well as high level of corruption and mismanagement of collected revenue. This research work under study heavily relied on secondary data to investigate the Impact of Information Communication Technology on Tax Administration in Kebbi State. The research recommends the need to put in place policy and legislation that will derive ICT adoption in tax administration in Kebbi State, training of revenue officers on Information Communication Technology related skills, designing, development and deployment of local content software in tax administration by the Kebbi State Board of Internal Revenue Service
Abstract B71: First ten malignancies by ranking from a population of rural Africans in Zaria, Nigeria: A fourteen years review and report
No full textAbstract
Every environment is noted for its variability in incidences of various malignancies and subtypes. The objective of this study is to analyze the trend of malignant tumors in a population of rural Africans attending Ahmadu Bello University Teaching Hospital Zaria, Nigeria with particular emphasis on the first ten most frequently diagnosed cancers over a period of 14 consecutive years (2001-2014).
Histologically diagnosed cancers in the various cancer registries of the ABUTH Zaria were included in this study. The ten most commonly presenting cancers were extracted and their demographic characteristics and other relevant clinical data documented using a standardized questionnaire. The data obtained were analyzed using SPSS software version 20.0.
There were 6,553 histologically diagnosed cancers over 14 years in Ahmadu Bello Unibersity Teaching Hospital Zaria with the following in descending order: Cervical cancer 1042 (15.90%), Breast cancer 788 (12.02%), Prostate cancer 496 (7.56%), Colorectal cancer 360 (5.49%), Lymphoma 306 (4.66%), Eye/orbit cancer 170 (2.59%), Bladder cancer 169 (2.45%), Nasopharyngeal cancer 139 (2.12%), Ovarian cancers 94 (1.43%), and Liver cancer 52 (0.79%).
Cervical cancer tops the list as the most frequently diagnosed cancer however, this should be noted that it is a cancer exclusive to females so also breast cancers though rarely males may present with breast cancer. Prostate cancer is a male exclusive disease therefore the percentage would have been higher if the diagnosis would have excluded the females. Of the ten most frequently diagnosed cancers, liver cancer is the tenth despite the fact that complications of viral hepatitidis are known to facilitate liver carcinogenesis and the prevalence of hepatitis C and B in the Nigerian population is 5 and 20 respectively.
Citation Format: Abdulmumini Hassan Rafindadi, Surajo Mohammed Aminu, Mohammed Faruk, Yawale Iliyasu, Abdullahi Mohammed, Sani Ibrahim, Ahmed Adamu, Mohammed Sani Shehu, Abdullahi Jubril Randawa, Adamu Abdullahi, Saad Aliyu Ahmed, Maitama Yusuf Hussaini, Danladi Amodu Ameh, Ukwenya Yahaya, John Idoko, Oguntayo Olanrewaju Adekunle, Almustapha Aliyu Liman, Abdulkadir Lawal Rafindadi, Aisha Maude Suleiman, Jigo Dangude Yaro, Ahmad Bello, Bello Kumo. First ten malignancies by ranking from a population of rural Africans in Zaria, Nigeria: A fourteen years review and report. [abstract]. In: Proceedings of the Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2016 Sep 25-28; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(2 Suppl):Abstract nr B71.</jats:p
Abstract 4918: Is Livin a protagonist of mucinous adenocarcinoma histology in colorectal cancer
No full textAbstract
The mechanism of cancer resistance to chemotherapy regimen remains uncertain. Colorectal mucinous adenocarcinoma is one of the distinct histological subtypes of the disease implicated in chemotherapeutic resistance associated with nodal and peritoneal metastases and worse disease-free survival as an index of poor prognosis. One of the important acquired capabilities used by the cancer cells to resist anticancer therapies is evasion of apoptosis possibly via inhibitor of apoptosis proteins for which Livin is one. This protein contains baculoviral IAP repeat domains in addition to a RING finger, a protein-protein motif important for binding and inhibition of active caspases that interfere with intrinsic and/or extrinsic pathway and the ensuing blockade of apoptosis. Thus, understanding the molecular events on how cancer cells of mucinous histology evade apoptotic death may provide a novel paradigm for a molecular targeted therapy in the management of colorectal mucinous adenocarcinoma. In this study, the expression pattern and prognostic value of IAP family protein, Livin, in colorectal cancer patients with mucinous histology pre and post-chemotherapy regimen was investigated. Tissue sections from advanced stage colorectal cancer patients who were treated or untreated with neo-adjuvant FOLFOX chemotherapy before curative resection were included in this study. The tissue sections were grouped according to colorectal adenocarcinomas showing mucinous histology and non-mucinous component. Histological study including Haematoxylin and Eosin, and immunohistochemistry for Anti-Livin and DNA mismatched repair proteins were carried out. Immunofluorescence study was performed to clarify the expression pattern of the protein using Anti-Livin antibody. Protein expression quantification study was also used. Results show significant cytoplasmic localisation and expression of Livin protein in the colorectal cancer cells. The Livin protein expression was found to be increased by more than a one-fold post-chemotherapy treatment when compared with pre-chemotherapy treated patients with mucinous histology of colorectal cancer. Younger patients were found to have a greater probability of colorectal mucinous adenocarcinoma diagnosis and worse prognosis. Our findings show that Livin-induced inhibition of apoptosis activity can be a target for novel approaches to treatment and prevention of chemotherapy associated drug resistance in mucinous histology colorectal cancer since Livin overexpression has been associated with metastases and worse disease-free survival. More study is needed
Citation Format: Mohammed Faruk, Abdulmumini Hassan Rafindadi, Sani Ibrahim, Surajo Mohammed Aminu, Surajo Mohammed Aminu, Ahmed Adamu, Ahmed Adamu, Yawale Iliyasu, Adamu Abdullahi, Mohammed Sani Shehu, Abdullahi Mohammed, John Idoko, Abdullahi Jibril Randawa, Abdullahi Jibril Randawa, Atara Ntekim, Saad Aliyu Ahmed, Aishatu Suleiman Maude, Almustapha Aliyu Liman, Abubakar Sani, Khalid Zahir Shah, Yahaya Ukwenya, Yahaya Ukwenya, Cheh Augustine Awasum, Kasimu Umar Adoke, James Olowu Enemari, James Olowu Enemari, James Olowu Enemari, Andrew Jonathan Nok. Is Livin a protagonist of mucinous adenocarcinoma histology in colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4918. doi:10.1158/1538-7445.AM2017-4918</jats:p
Disseminated Langerhan's cell histiocytosis: A case report and review of the literature
No full textLangerhan′s cell histiocytosis is characterized by the presence
of large mononucleated cells associated with inflammatory cells. We
describe the clinical presentation, histopathology and some
immunohistochemistry findings, in an eight-year-old female patient
GENETIC LANDSCAPES OF EPITHELIAL OVARIAN CANCERS IN NIGERIAN WOMEN: PROTOCOL AND INSIGHTS FROM THE FIRST 27 CASES
No full textGENETIC LANDSCAPES OF EPITHELIAL OVARIAN CANCERS IN NIGERIAN WOMEN: PROTOCOL AND INSIGHTS FROM THE FIRST 27 CASES
No full textDisseminated Langerhan's cell histiocytosis: A case report and review of the literature
No full textLangerhan′s cell histiocytosis is characterized by the presence
of large mononucleated cells associated with inflammatory cells. We
describe the clinical presentation, histopathology and some
immunohistochemistry findings, in an eight-year-old female patient
