10 research outputs found
Poly(styrene-co-maleic anhydride) modified with nickel sulfate and its application in the synthesis of 2-amino-4H-chromenes
No full textIn this project, crosslinked Styrene-Co-Maleic anhydride Polymer Catalyst modified with NiSO4 hexahydrate, as an efficient heterogeneous polymer-based nanocatalyst was synthesized in three steps. First, Styrene-Co-Maleic anhydride polymer was synthesized by radical polymerization of styrene in maleic anhydride, then the resulted copolymer was crosslinked with 1,3-phenylenediamine and finally the crosslinked copolymer was modified with NiSO4. This polymer-based nanocatalyst was investigated and identified using Fourier-transform infrared spectroscopy (FT-IR), Energy Dispersive X-Ray (EDX) (EDX), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM). In order to investigate the catalytic properties of CPSMA-Ni, the synthesis of various types of 2-amino-4H-chromane derivatives was investigated using the reaction of aldehyde derivatives with malononitrile in the presence of dimedone, resorcinol or naphthols. 2-Amino-4H-Cromans were synthesized with good to excellent efficiency (85%-96%) under mild conditions. This heterogeneous polymeric catalyst has a good performance in the synthesis of chromium derivatives. This catalyst can be recycled without pre-activation and reloaded up to 5 consecutive runs without significant decrease in its efficiency
Ionic Liquid-Assisted Fabrication of Bioactive Heterogeneous Magnetic Nanocatalyst with Antioxidant and Antibacterial Activities for the Synthesis of Polyhydroquinoline Derivatives
No full textAntibacterial materials have obtained much attention in recent years due to the presence of hazardous agents causing oxidative stress and observation of pathogens. However, materials with antioxidant and antibacterial activities can cause toxicity due to their low biocompatibility and safety profile, urging scientists to follow new ways in the synthesis of such materials. Ionic liquids have been employed as a green and environmentally solvent for the fabrication of electrically conductive polymers. In the present study, an antibacterial poly(p-phenylenediamine)@Fe3O4 (PpPDA@Fe3O4) nanocomposite was fabricated using [HPy][HSO4] ionic liquid. The chemical preparation of PpPDA@Fe3O4 nanocomposite was initiated through the oxidative polymerization of p-phenylenediamine by ammonium persulfate in the presence of [HPy][HSO4]. The PpPDA@Fe3O4 nanocomposite exhibited antibacterial properties against Gram-negative (Escherichia coli) and Gram-positive (Bacillus subtilis) bacteria. The PpPDA@Fe3O4 nanocomposite was employed as a heterogeneous nanocatalysis for one-pot synthesis of polyhydroquinoline derivatives using aromatic aldehyde, dimedone, benzyl acetoacetate, and ammonium acetate. Polyhydroquinoline derivatives were synthesized in significant yields (90–97%) without a difficult work-up procedure in short reaction times. Additionally, PpPDA@Fe3O4 nanocatalyst was recycled for at least five consecutive catalytic runs with a minor decrease in the catalytic activity. In this case, 11 derivatives of polyhydroquinoline showed in vitro antioxidant activity between 70–98%
NIR-responsive engineered colloidal polyaniline/ZnO/UiO-66-NH₂ nanoplatform: A multifunctional photothermal agent for precision therapy in breast cancer
No full textA colloidal polyaniline/ZnO/UiO-66-NH₂ (PANI/ZnO/UiO-66-NH₂) nano-platform was constructed in two steps. The nano-platform exhibited strong optical absorption in the near-infrared (NIR) region, enabling efficient conversion of optical energy into thermal energy under 808-nm laser irradiation, thereby facilitating tumor cell ablation. Characterization was performed using FT-IR, EDX, XRD, FESEM, UV-Vis, and TG. Biological activities, including antioxidant and antibacterial properties, as well as cytotoxicity, were evaluated. The nanocomposite exhibited high photothermal efficiency, reaching 60 °C in 10 min under an 808 nm NIR laser (0.6 W/cm², 1.5 mg/mL), confirming its potential for hyperthermia-based cancer therapy. At 0.15 mg/mL, the temperature rose to 49 °C, demonstrating its concentration and laser power dependence for effective photothermal therapy (PTT). In vitro cytotoxicity analysis on MCF-7 breast cancer cells showed a significant reduction in cell viability under NIR laser irradiation. The MTT assay confirmed that combining the nanocomposite with laser treatment led to a substantial decrease in cancer cell survival, highlighting its potential as a photothermal agent. Additionally, the antioxidant activity of the colloidal PANI/ZnO/UiO-66-NH₂ nanocomposite was found to be 90.64 %, comparable to the highest observed efficiency of UiO-66-NH₂ (94.20 %), and potent antibacterial effects against Escherichia coli (E. coli), Bacillus subtilis (B. subtilis), Salmonella enteritidis (S. enteritidis), and Staphylococcus aureus (S. aureus). Inhibition zone diameters for S. enteritidis and E. coli were 15 ± 0.3 mm and 13 ± 0.1 mm, respectively, underscoring dual applicability in PTT and antibacterial therapy. The MTT assay revealed that colloidal PANI/ZnO/UiO-66-NH₂ reduced the viability of MCF-7 cells to 40 % after 48 h of exposure. The IC₅₀ value of the colloidal PANI/ZnO/UiO-66-NH₂ for inhibiting the growth of MCF-7 cells increased from 17.13 µg/mL after 24 h to 32.3 µg/mL after 48 h. Additionally, hemolysis testing demonstrated that the nano-platform exhibited a hemolysis rate of 5 % at a concentration of 100 μg/mL. These results highlight the nanocomposite’s broad biomedical potential
Magnetic poly(1,8-diaminonaphthalene)-nickel nanocatalyst for the synthesis of antioxidant and antibacterial isoxazole-5(4H)-ones derivatives
No full textA magnetic poly (1,8-diaminonaphthalene)-nickel (PDAN-Ni@Fe3O4) composite as a multifunctional nanocatalyst was prepared in several steps including (I) synthesis of poly (1,8-diaminonaphthalene) (PDAN), (II) modification of PDAN with NiSO4 (PDAN-Ni) and (III) preparation of magnetic nanocatalyst by iron (I and II) salts in the existence of PDAN-Ni complex (PDAN-Ni@Fe3O4). Fourier-transform infrared spectroscopy (FTIR), elemental analysis (CHNSO), vibrating-sample magnetometer (VSM), X-ray diffraction (XRD), energy-dispersive X-ray (EDX), field emission scanning electron microscope (FESEM), ultraviolet–visible (UV–vis), and thermogravimetric analysis (TGA) were applied to characterize the prepared nanocatalyst. The PDAN-Ni@Fe3O4 was applied as an environmentally friendly nanocatalyst for the isoxazole-5(4H)-ones synthesis via a one-pot reaction between aryl/heteroaryl aldehyde, hydroxylamine hydrochloride, and β-ketoester. The nanocomposite was also used for the synthesis of some new alkylene bridging bis 4-benzylidene-3-methyl isoxazole-5(4H)-ones. The catalyst's reusability, and the antioxidant and antibacterial activities of both catalyst and products, were studied. Results showed that the nanocatalyst and isoxazole-5(4H)-ones have antioxidant activity of 75% and 92%, respectively. In addition, the antibacterial test showed that the nanocatalyst and isoxazole-5(4H)-ones have highly active versus Staphylococcus aureus and Escherichia coli bacteria. The reusability and stability of the nanocatalyst, a medium to higher product yield and conversion, a faster reaction time, and the use of green solvents were a few benefits of this study
Engineered PVC ultrafiltration membranes with amine-functionalized MOFs for water treatment: A comparative study on dye removal and antibacterial performance
No full textThis study developed poly(vinyl chloride)(PVC)-based ultrafiltration membranes enhanced with amino-functionalized MIL-101–NH2 (Al/Cr) metal–organic frameworks (MOFs) using the phase inversion method. The membranes were characterized by FTIR, SEM, AFM, and contact angle measurements. The incorporation of MOFs significantly improved membrane hydrophilicity, porosity (up to ∼85 %), and water uptake (nearly 80 %), with the M2 (Cr) and M2 (Al) composites showing the optimal performance balance. Incorporation of MIL-101–NH2 noticeably improved membrane performance by increasing porosity to around 85 % and water uptake to nearly 80 %. Among the fabricated membranes, M2 (Cr) and M2 (Al) showed the most favorable balance between pore structure and hydrophilicity. As a result, these optimized membranes demonstrated a marked enhancement in pure water flux, reaching about 534.7 L m−2 h−1 for M2 (Cr) and 526.2 L m−2 h−1 for M2 (Al), compared with only 276.7 L m−2 h−1 for the pristine PVC membrane. Performance tests indicated that introducing hydrophilic –NH2 groups and interconnected pores significantly improved pure water flux compared to pristine PVC. The optimized membranes exhibited effective removal of humic acid (≈70–80 %), methyl orange (≈29 %), and methylene blue (≈47 %) due to the combined effects of size exclusion and electrostatic interactions. They also demonstrated enhanced antifouling behavior, with flux recovery ratios (FRR) of approximately 51–52 % for the best-performing membranes, indicating improved cleaning efficiency relative to pristine PVC. Antibacterial evaluation using the Kirby–Bauer disk diffusion method revealed that MIL-101–NH2(Al) membranes displayed broader antibacterial activity against E. coli, S. aureus, and S. enteritidis, whereas MIL-101–NH2(Cr) showed selective activity mainly against E. coli and B. subtilis
Synthesis, and Anticancer Evaluation of 4-[(Indol-3-yl)-arylmethyl]-1-phenyl-3-methyl-5-pyrazolone Derivatives via a Magnetic Aminated Starch Biocatalyst
No full textAn eco-friendly biocatalyst was constructed in three steps. In the first step, the tosylated starch (TsST) was synthesized by using a 4-toluenesulfonyl chloride. In the second step, the aminated starch was synthesized via the reaction of TsST with para-phenylenediamine. In the third step, the magnetic biocatalyst was fabricated by an in situ coprecipitation process from ferric and ferrous salts in the existence of aminated starch (AST). The biocatalyst was characterized by 1H NMR, EDX, FESEM, FTIR, VSM, and TGA analyses. The magnetic aminated starch (MAST) was used as a biocatalyst for the synthesis of 4-[(indol-3-yl)-arylmethyl]-1-phenyl-3-methyl-5-pyrazolone derivatives. The various products were prepared in noteworthy yields (85–93%) in fast reaction times (35–80 min) without laborious work-up procedures. The anticancer evaluation of some 4-[(indol-3-yl)-arylmethyl]-1-phenyl-3-methyl-5-pyrazolones derivatives was studied on the survival rate of breast cancer cell lines (MCF-7) and human fibroblast cells by using an MTT assay. Additionally, recovery of the biocatalyst was studied, and results showed that the MAST was easily isolated from the reaction flask and could be recycled for up to six consecutive cycles without meaningfully falling in its efficiency
Preparation of poly (styrene-co-maleic anhydride) based magnetic nanocomposite as an effective catalyst for the synthesis of 3,2-dihydroquinazoline-4 (1H) derivatives
No full textAbstract: In this study, a magnetic nanocomposite based on poly (styrene-co-maleic anhydride) (Fe3O4 @ PSMASA) was prepared in three steps. In the first step, poly (styrene-co-maleic anhydride) was prepared from the radical polymerization reaction of styrene and maleic anhydride monomers. In the second step, the iron oxide magnetic nanoparticles prepared by co-precipitation method were functionalized using 3-aminopropyltriethoxycylan (APTES). In the third step, the maleic anhydride ring in the copolymer was modified with sulfanilic acid and amine-activated magnetic iron nanoparticles to form carboxylic acid and sulfonic acid groups on poly (styrene-co-maleic anhydride). The catalytic activity of the resulted Fe3O4 @ PSMASA was investigated in the three-component reaction of isatoic anhydride, amines and aldehydes in ethanol as solvent. This method led to the synthesis of various derivatives of 3,2-dihydroquinazoline-4 (1H) in high yields. The catalyst can be recovered and reused in the reaction without significant loss catalytic activity. The other advantages of this method include high efficiencies, mild reaction conditions, good performance and environmental friendliness
Magnetic Sulfonated Melamine-Formaldehyde Resin as an Efficient Catalyst for the Synthesis of Antioxidant and Antimicrobial Pyrazolone Derivatives
No full textSulfonated polymer-based materials, among heterogeneous catalysts, are frequently utilized in chemical transformations due to their outstanding chemical and physical durability. In this regard, a magnetic sulfonated melamine–formaldehyde resin (MSMF) catalyst was successfully prepared from a mixture of sulfonated melamine–formaldehyde and Fe3O4 nanoparticles in two steps. MSMF was used as a heterogeneous catalyst for the one-pot, three-component condensation of benzyl pyrazolyl naphthoquinones in water as a green solvent and 4-[(indol-3-yl)-arylmethyl]-1-phenyl-3-methyl-5-pyrazolones. The antimicrobial and antioxidant activities of catalyst, benzyl pyrazolyl naphthoquinones, and 4-[(indol-3-yl)-arylmethyl]-1-phenyl-3-methyl-5-pyrazolones were evaluated using agar disk-diffusion and DPPH assays, respectively. The antioxidant activity of the catalyst and 4-[(indol-3-yl)-arylmethyl]-1-phenyl-3-methyl-5-pyrazolones was found to be 75% and 90%, respectively. Furthermore, catalyst, benzyl pyrazolyl naphthoquinones, and 4-[(indol-3-yl)-arylmethyl]-1-phenyl-3-methyl-5-pyrazolones exhibited antimicrobial activity against Staphylococcus aureus and Escherichia coli. In conclusion, MSMF is a superior catalyst for green chemical processes, owing to its high catalytic activity, stability, and reusability
DataSheet1_Poly(aniline-co-melamine)@MnFe2O4 nanocatalyst for the synthesis of 4,4′-(arylmethylene) bis (1H-pyrazole-5-ol) derivatives, and 1,4- dihydropyrano[2,3-c]pyrazoles and evaluation of their antioxidant, and anticancer activities.docx
No full textIn this work, magnetic poly(aniline-co-melamine) nanocomposite as an efficient heterogeneous polymer-based nanocatalyst was fabricated in two steps. First, poly(aniline-co-melamine) was synthesized through the chemical oxidation by ammonium persulfate, then the magnetic nanocatalyst was successfully prepared from the in-situ coprecipitation method in the presence of poly(aniline-co-melamine). The resulting poly(aniline-co-melamine)@MnFe2O4 was characterized by FTIR, FESEM, XRD, VSM, EDX, TGA, and UV-vis analyses. The catalytic activity of poly(aniline-co-melamine)@MnFe2O4 was investigated in the synthesis of 4,4′-(arylmethylene)bis(1H-pyrazole-5-ol) derivatives, and new alkylene bridging bis 4,4′-(arylmethylene)bis(1H-pyrazole-5-ol) derivatives in excellent yields. The yield of 1,4-dihydropyrano[2,3-c]pyrazoles, 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol), yields, and new alkylene bridging bis 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol) derivatives were obtained 89%–96%, 90%–96%, and 92%–96%, respectively. The poly(aniline-co-melamine)@MnFe2O4 nanocatalyst can be recycled without pre-activation and reloaded up to five consecutive runs without a significant decrease in its efficiency. In addition, the antioxidant activity of some derivatives was evaluated by DPPH assay. Results showed that the maximum antioxidant activity of 4,4′-(arylmethylene)bis(1H-pyrazole-5-ol) derivatives and 1,4-dihydropyrano[2,3-c]pyrazoles were 75% and 90%, respectively. Furthermore, 4,4′-(arylmethylene)bis(1H-pyrazole-5-ol) derivatives and 1,4-dihydropyrano[2,3-c]pyrazoles showed good potential for destroying colon cancer cell lines. Consequently, the poly(aniline-co-melamine)@MnFe2O4 nanocomposite is an excellent catalyst for green chemical processes owing to its high catalytic activity, stability, and reusability.</p
Progress in translating bioinorganic nanoplatform discoveries into clinical lung cancer care: Overcoming limitations, targeted drug delivery and imaging
No full textLung cancer remains as the leading cause of cancer-related fatalities globally, posing significant challenges to conventional treatment methods, particularly in advanced stages where limitations and adverse effects are prevalent. Nanotechnology offers promising solutions to enhance lung cancer therapy. Inorganic nanomaterials, such as metal nanoparticles, rare earth elements, and carbonaceous materials, exhibit unique properties that can address these challenges. Metal nanoparticles facilitate targeted drug delivery, biosensing, and imaging, while rare earth elements demonstrate selective cytotoxic effects and imaging capabilities. Carbonaceous materials find applications in biosensing and drug delivery, including carbon ion radiotherapy. These advancements in inorganic nanomaterials present an opportunity to revolutionize lung cancer treatment, potentially leading to improved outcomes and better patient well-being. This paper focuses on recent progress in utilizing inorganic nanomaterials for treating lung cancer, aiming to provide a clearer understanding of their benefits compared to conventional treatments, along with an in-depth examination of their associated limitations and adverse effects
