570 research outputs found
Robert Phillip Sharp
No full textRobert Phillip Sharp, one of the
leading figures of American geology,
died peacefully in his home in
Santa Barbara, California, on 25 May
2004. Bob’s enormous contributions
on the physical processes that have
modified the surfaces of Earth and
Mars are scientific classics that have
substantially enhanced our understanding
of the unique roles of water,
wind, and ice in modifying planetary
surfaces. Virtually an equal contribution
was Bob’s vision and leadership
in geological academia, primarily at
Caltech
Characterization of urinary sulfatides in metachromatic leukodystrophy using electrospray ionization-tandem mass spectrometry
No full textWhitfield, Phillip D. ; Sharp, Peter C. ; Johnson, David W. ; Nelson, Paul ; Meikle, Peter J
Dark Moon Shallow Sea (The Gods of Night and Day Series, vol. 1) by David R. Slayton
No full textBook review of Dark Moon Shallow Sea (The Gods of Night and Day Series, vol 1) by author David R. Slayton. Book review by Phillip Fitzsimmons
Wright Radio Interview About Westview Festival and David R. Slayton
No full textSWOSU President Dr. Diana Lovell and University Archivist and Special Collections Librarian Phillip Fitzsimmons were interviewed by Todd Brunner at Wright Radio on March 27th, 2025 from 7:00-7:30 AM
The interview focused on the upcoming annual Westview Festival and keynote speaker David R. Slayton.
The annual Westview Festival will be on Wed. April 16th from 6:00-7:00 PM at the SWOSU Hilltop Theater. The event is free and open to the public.
David R. Slayton is an adult fantasy author from Guthrie, OK. and has written such titles as White Trash Warlock and Dark Moon Shallow Sea
Endogenous miRNA and Target Concentrations Determine Susceptibility to Potential ceRNA Competition
No full textTarget competition (ceRNA crosstalk) within miRNA-regulated gene networks has been proposed to influence biological systems. To assess target competition, we characterize and quantitate miRNA networks in two cell types. Argonaute iCLIP reveals that hierarchical binding of high- to low-affinity miRNA targets is a key characteristic of in vivo activity. Quantification of cellular miRNA and mRNA/ncRNA target pool levels indicates that miRNA:target pool ratios and an affinity partitioned target pool accurately predict in vivo Ago binding profiles and miRNA susceptibility to target competition. Using single-cell reporters, we directly test predictions and estimate that ∼3,000 additional high-affinity target sites can affect active miRNA families with low endogenous miRNA:target ratios, such as miR-92/25. In contrast, the highly expressed miR-294 and let-7 families are not susceptible to increases of nearly 10,000 sites. These results show differential susceptibility based on endogenous miRNA:target pool ratios and provide a physiological context for ceRNA competition in vivo.National Institutes of Health (U.S.) (Grants RO1-GM34277 and R01-CA133404)National Cancer Institute (U.S.) (Grants PO1-CA42063 and F32CA139902)National Cancer Institute (U.S.) (Cancer Center Support Core Grant P30-CA14051
Gerontoformica Nel and Perrault
No full textGerontoformica Nel and Perrault Gerontoformica Nel and Perrault, 2004: pg. 24. Type species: G. cretacica Nel and Perrault, by original designation. In Albian-aged amber from France. Sphecomyrmodes Grimaldi and Engel, 2005: pg. 5. Type species: Sphecomyrmodes orientalis, by original designation. In Burmese amber. New synonymy. Diagnosis (Emended). Distinguished from other Cretaceous genera by an uninterrupted row of peg-like denticles on the anterior margin of the clypeus; mandibles falcate, with one large apical tooth and one preapical tooth. The revised diagnosis and new generic synonymy is based on re-examination by one author (P.B.) of the type specimen, officially housed at the National Museum of Natural History, Paris. Species formerly placed in Sphecomyrmodes [16, 20, 25] are now placed in Gerontoformica.Published as part of Phillip Barden & David A. Grimaldi, 2016, Adaptive Radiation in Socially Advanced Stem-Group Ants from the Cretaceous, pp. 515-521 in Current Biology 26 on page 518, DOI: 10.1016/j.cub.2015.12.060, http://zenodo.org/record/26953
[Letter to Newt Gingrich from David Baltimore, David Ho, Philip A. Sharp, and Torsten N. Wiesel]
No full textTips for generating a media release and media coverage : how the media ate up my research on Aussie horror movies
No full textThe focus of this paper is preparing research for dissemination by mainstream print, broadcast, and online media. While the rise of the blogosphere and social media is proving an effective way of reaching niche audiences, my own research reached such an audience through traditional media. The first major study of Australian horror cinema, my PhD thesis A Dark New World: Anatomy of Australian Horror Films, generated strong interest from horror movie fans, film scholars, and filmmakers. I worked closely with the Queensland University of Technology’s (QUT) public relations unit to write two separate media releases circulated on October 13, 2008 and October 14, 2009. This chapter reflects upon the process of working with the media and provides tips for reaching audiences, particularly in terms of strategically planning outcomes. It delves into the background of my study which would later influence my approach to the media, the process of drafting media releases, and key outcomes and benefits from popularising research. A key lesson from this experience is that redeveloping research for the media requires a sharp writing style, letting go of academic justification, catchy quotes, and an ability to distil complex details into easy-to-understand concepts. Although my study received strong media coverage, and I have since become a media commentator, my experiences also revealed a number of pitfalls that are likely to arise for other researchers keen on targeting media coverage
Rbfox2 controls autoregulation in RNA-binding protein networks
No full textThe tight regulation of splicing networks is critical for organismal development. To maintain robust splicing patterns, many splicing factors autoregulate their expression through alternative splicing-coupled nonsense-mediated decay (AS-NMD). However, as negative autoregulation results in a self-limiting window of splicing factor expression, it is unknown how variations in steady-state protein levels can arise in different physiological contexts. Here, we demonstrate that Rbfox2 cross-regulates AS-NMD events within RNA-binding proteins to alter their expression. Using individual nucleotide-resolution cross-linking immunoprecipitation coupled to high-throughput sequencing (iCLIP) and mRNA sequencing, we identified >200 AS-NMD splicing events that are bound by Rbfox2 in mouse embryonic stem cells. These “silent” events are characterized by minimal apparent splicing changes but appreciable changes in gene expression upon Rbfox2 knockdown due to degradation of the NMD-inducing isoform. Nearly 70 of these AS-NMD events fall within genes encoding RNA-binding proteins, many of which are autoregulated. As with the coding splicing events that we found to be regulated by Rbfox2, silent splicing events are evolutionarily conserved and frequently contain the Rbfox2 consensus UGCAUG. Our findings uncover an unexpectedly broad and multilayer regulatory network controlled by Rbfox2 and offer an explanation for how autoregulatory splicing networks are tuned.United States. Public Health Service (RO1-GM34277)National Cancer Institute (U.S.). Integrative Cancer Biology Program (Grant CA112967)National Cancer Institute (U.S.) (Koch Institute Support (Core) Grant P30-CA14051)David H. Koch Graduate Fellowshi
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