16,853 research outputs found
Oral History Interview of David Sharp (Part 1 of 2)
No full textOral history interview of David Sharp by David Tilford, January 19, 2008, at the Sheepherders Gathering at the Border Inn, Baker, Nev., Part 1 of
Oral History Interview of David Sharp (Part 2 of 2)
No full textOral history interview of David Sharp by David Tilford, January 19, 2008, at the Sheepherders Gathering at the Border Inn, Baker, Nev., Part 2 of
Evolution of cooperation among tumor cells
No full textThe evolution of cooperation has a well established theoretical framework based on game theory. This approach has made valuable contributions to a wide variety of disciplines, including political science, economics, and evolutionary biology. Existing cancer theory suggests that individual clones of cancer cells evolve independently from one another, acquiring all of the genetic traits or hallmarks necessary to form a malignant tumor. It is also now recognized that tumors are heterotypic, with cancer cells interacting with normal stromal cells within the issue microenvironment, including endothelial, stromal, and nerve cells. This tumor cell???stromal cell interaction in itself is a form of commensalism, because it has been demonstrated that these nonmalignant cells support and even enable tumor growth. Here, we add to this theory by regarding tumor cells as game players whose interactions help to determine their Darwinian fitness. We marshal evidence that tumor cells overcome certain host defenses by means of diffusible products. Our original contribution is to raise the possibility that two nearby cells can protect each other from a set of host defenses that neither could survive alone. Cooperation can evolve as byproduct mutualism among genetically diverse tumor cells. Our hypothesis supplements, but does not supplant, the traditional view of carcinogenesis in which one clonal population of cells develops all of the necessary genetic traits independently to form a tumor. Cooperation through the sharing of diffusible products raises new questions about tumorigenesis and has implications for understanding observed phenomena, designing new experiments, and developing new therapeutic approaches.Author manuscript. Published in final edited form as: Proc Natl Acad Sci U S A. 2006 September 5; 103(36): 13474-13479.The final published version of this article is located at: www.pnas.org/cgi/doi/10.1073/pnas.0606053103NIH U56 CA113004; to David E. AxelrodR.A. was supported by National Science Foundation (NSF) Grant SES-0240852. D.E.A. was supported by NSF Grant IIS-0312953, National Institutes of Health (NIH) Grant U56 CA113004, and New Jersey Commission on Cancer Research Grant 1076-CCR-SO. K.J.P. is an American Cancer Society Clinical Research Professor and is supported by NIH Grants CA69568, CA102872, and CA093900.NIH CA69568; to Kenneth J. PientaNIH CA102872; to Kenneth J. PientaNIH CA093900; to Kenneth J. PientaNSF SES-0240852; to Robert AxelrodNJ Commission on Cancer Research 1076-CCR-SO; to David E. AxelrodAlso available in PubMed Central. PMCID: PMC155738
The Arts Interview. Dr. David Pitt : The Truant Years, E. J. Pratt
No full textHost Fred Hollingshurst interviews Dr. David Pitt of Memorial University, who discusses the life and work of Newfoundland poet E. J. Pratt. Pitt is the author of E. J. Pratt: The Truant Years, 1881-1927
Faculty concert: William Sharp, baritone, Robert Merfeld, piano, Peter Zazofsky, violin, Michael Reynolds, cello
No full textThis is the concert program of the Faculty Concert: William Sharp, baritone, Robert Merfeld, piano, Peter Zazofsky, violin, Michael Reynolds, cello performance on Thursday, March 23, 2000 at 8:00 p.m., at the Tsai Performance Center, 685 Commonwealth Avenue. Works performed were Hier in meines Vaters Statte by Johann Sebastian Bach, Sturze zu Boden by J. S. Bach, Nichts ist es spat und fruhe by J. S. Bach, Under the Resurrection Palm by David Liptak, Six Songs for voice, violin, and piano, Op. 54 by Louis Spohr, and La Bonne Chanson, Op. 62 by Gabriel Faure. Digitization for Boston University Concert Programs was supported by the Boston University Humanities Library Endowed Fund
KLP10A and KLP59C: the dynamic duo of microtubule depolymerization
No full textKinesin-13s are important effectors of microtubule depolymerization in cells. In a recent series of studies, we examined the roles played by kinesin-13s throughout the cell cycle in Drosophila. Our findings have revealed remarkable coordination between two family members, KLP10A and KLP59C, in which alterations in the relative targeting of these proteins allows them to participate in markedly different tasks at distinct points in the cell cycle. During mitosis, KLP10A and KLP59C function in parallel by targeting to and depolymerizing the opposite ends of kinetochore-associated microtubules, thereby driving poleward chromatid motility by a Pacman-Flux mechanism. Alternatively, during interphase, both proteins target to the same end of the microtubule but act in series to divide the labor of microtubule depolymerization. KLP10A initiates depolymerization while KLP59C perpetuates depolymerization after its initiation. Below, we detail these findings and examine some of their implications.</p
A sharp Bogomolov-type bound
No full textWe prove a sharp lower bound for the essential minimum of a nontranslate variety in certain abelian varieties. This uses and generalises a result of Galateau. Our bound is a new step in the direction of an abelian analogue by David and Philippon of a toric conjecture of Amoroso and David and has applications in the framework of anomalous intersections
Fly about round me coursing, swallow sweet birds come near [first line]
No full textstrophicpiano and voiceCover is duplicated in 125.115b.Johns Hopkins University, Levy Sheet Music Collection, Box
125, Item 115aTranslated From the French of Volney L'Hotelier by Samuel J. Gardner, Esq. The Music by Felicien David (Author of "Le Desert").E.G. Warren, Engr
Fly about round me coursing, swallow sweet birds come near [first line]
No full textstrophicpiano and voiceCover is duplicated in 125.115b.Johns Hopkins University, Levy Sheet Music Collection, Box
125, Item 115aTranslated From the French of Volney L'Hotelier by Samuel J. Gardner, Esq. The Music by Felicien David (Author of "Le Desert").E.G. Warren, Engr
Characterization of urinary sulfatides in metachromatic leukodystrophy using electrospray ionization-tandem mass spectrometry
No full textWhitfield, Phillip D. ; Sharp, Peter C. ; Johnson, David W. ; Nelson, Paul ; Meikle, Peter J
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