131,519 research outputs found
Messages of commendation and Press releases for John D. Sharman
No full textThis is a six page document that contain messages of praise written about John D. Sharman. The messages are written by different people at different places where he has spoken or been present. The messages also show his movements and where he was stationed at various points. Pages 5 and 6 are press comments on him.This document/photograph was contained within an envelope held in the back of the scrapbook. It has been removed and placed within a folder in the back of the scrapbook.
A letter from John D. Sharman to Georgian E. Carr (May 5, 1919)
No full textA letter from John D. Sharman to Georgian E. Carr, dated May, 1919. The letter talks about his time with the Canadian Armed forces during World War I.This document/photograph was contained within an envelope held in the back of the scrapbook. It has been removed and placed within a folder in the back of the scrapbook.
Messages of commendation and Press releases for John D. Sharman
No full textThis is a six page document that contain messages of praise written about John D. Sharman. The messages are written by different people at different places where he has spoken or been present. The messages also show his movements and where he was stationed at various points. Pages 5 and 6 are press comments on him.This document/photograph was contained within an envelope held in the back of the scrapbook. It has been removed and placed within a folder in the back of the scrapbook.
A letter from John D. Sharman to Georgian E. Carr (May 5, 1919)
No full textA letter from John D. Sharman to Georgian E. Carr, dated May, 1919. The letter talks about his time with the Canadian Armed forces during World War I.This document/photograph was contained within an envelope held in the back of the scrapbook. It has been removed and placed within a folder in the back of the scrapbook.
John D. Sharman
No full textA portrait photograph of John D. Sharman. He is photographs from the shoulders up. It is in a photographers, O. E. Hivernois, photo holder. It opens with two flaps. Front, middle and back have been scanned.This document/photograph was contained within an envelope held in the back of the scrapbook. It has been removed and placed within a folder in the back of the scrapbook.
John D. Sharman
No full textA portrait photograph of John D. Sharman. He is photographs from the shoulders up. It is in a photographers, O. E. Hivernois, photo holder. It opens with two flaps. Front, middle and back have been scanned.This document/photograph was contained within an envelope held in the back of the scrapbook. It has been removed and placed within a folder in the back of the scrapbook.
A portrait photograph of John D. Sharman
No full textA portrait photograph of John D. Sharman. He is in full uniform, standing in a studio. It is in a photographers, O. E. Hivernois, photo holder. It opens with two flaps. Front, middle and back have been scanned.This document/photograph was contained within an envelope held in the back of the scrapbook. It has been removed and placed within a folder in the back of the scrapbook.
A portrait photograph of John D. Sharman
No full textA portrait photograph of John D. Sharman. He is in full uniform, standing in a studio. It is in a photographers, O. E. Hivernois, photo holder. It opens with two flaps. Front, middle and back have been scanned.This document/photograph was contained within an envelope held in the back of the scrapbook. It has been removed and placed within a folder in the back of the scrapbook.
Studies on catecholamines and 5-hydroxytryptamine and the significance of their metabolites in animal tissues and body fluids
No full textThe papers presented in this thesis describe the development of
methods for the estimation of adrenaline, noradrenaline, dopamine,
5-hydroxytryptamine and some of their metabolites and the application
of such estimations to some problems of biological interest. The
major part of the thesis is concerned with the metabolism of these
amines in the mammalian central nervous system. The papers are
presented in three groups.The first group is made up of papers in which the estimation of
5-hydroxytryptamine (5-HT) or its metabolite 5-hydroxy-indol-3-yl
acetic acid (5-HIAA) was measured.1. On the question of the occurrence and metabolism of 5-hydroxy-tryptamine and related indole compounds in mammalian semen. By T. Mann,
R. P. Seamark and D. F. Sharman. Br. J. Pharmac. Chemother. 17, 208 -
217, 1961.In this paper it was shown conclusively that the semen of man, bull,
boar, ram and dog contains little or no 5-hydroxytryptamine.2. Drug-induced changes in the concentration of 5-0R indolyl compounds
in cerebrospinal fluid and caudate nucleus. By G. V. Ashcroft and
D. P. Sharman. Br. J. Pharmac. Chemother. 19. 155 - 160, 1962.Because of an earlier observation by Ashcroft and Sharman (Nature,
Lond.,186, 1050 - 1051, i960) that the cerebrospinal fluid of depressed
patients contained a lower concentration of 5-hydroxyindolyl compounds
than normal, the effect of reserpine, a drug known to reduce the
concentration of 5-hydroxytryptamine in the brain, on the concentration
of such compounds in the cerebrospinal fluid of the dog was examined.
It was found that the concentration of 5-hydroxyindolyl compounds in
the cerebrospinal fluid was increased after reserpine.3. The effect of a-methyldopa on the metabolism of 5-hydroxy-tryptamine in rat brain. By D. P. Sharman and S. E. Smith. J.
Neurochem. 403 - 406, 1962.In this paper, the concentration of 5-HIAA in the brain was used as
an index of the rate at which 5-HT was released in this tissue after
a-methyldopa, an inhibitor of the formation of 5-HT,was given to rats.4. The action of 2-aminotetralin ({3-tetrahydronaphthylamine) on the
metabolism of 5-hydroxytryptamine in the brain of the mouse.
By D. Robinson and D. P. Sharman. Br. J. Pharmao. Chemother. 29.
535 - 341, 1967.2-Aminotetralin causes a reduction in the concentration of 5-
hydroxyindol-3-ylacetic acid in the brain of the mouse (paper 12).
The possible causes of this effect were' examined.The second group consists mainly of papers which describe the
development of methods of estimating dopamine and its acid metabolites
3,4-dihydroxyphenylacetio acid (DOPAC) and 4-hydroxy-3-methoxyphenyl
acetic acid (homovanillic acidj HVA), their application to several
problems, chiefly to a study of the rate of utilisation of dopamine
in the brain and also the effect of drugs on the metabolism of
this amine.5. Chemical and physiological changes produced by arterial infusion
of dihydroxyphenylalanine into one cerebral hemisphere of the cat.
By R. Dagirmanjian, R. Laverty, P. Mantegazzini, D. P. Sharman and
M. Vogt. J. Neurochem. 10, 177 - 182, 1965.The infusion of 3,4-dihydroxyphenylalanine (DOPA) into one
carotid artery of the cat can cause arousal of the brain on the side
of the infusion. It was shown that this unilateral arousal is
accompanied by an increase in the concentration of dopamine in the
caudate nucleus, hypothalamus and midbrain reticular formation on
the same side of the brain.6. The subcellular localisation of dopamine and acetylcholine in the
dog caudate nucleus. By R. Laverty, I. A. Michaelson, D.P. Sharman and
V. P. Whittaker. Br. J. Pharmac. Chemother. 21, 482 - 490, 1963.7. Localisation of acetylcholine, 5-hydroxytryptamine and noradrenaline
within subcellular particles derived from guinea-pig subcortical brain
tissue. By I. A. Michaelson, V. P. Whittaker, R. Laverty and
D. P. Sharman. Biochem. Pharmacol. 12. 1450-1453, 1963.8. A fluorimetric method for the estimation ti 4-hydroxy-3-methoxyphenylacetic
acid (homovanillic acid) and its identification in brain
tissue. By D. F. Sharman. Br. J. Pharinac. Chemother. 20. 204 - 213, 1963.9. The estimation of small quantities of 3,4-dihydroxyphenylethylamine
in tissues. By R. Laverty and D. F. Sharman. Br. J. Pharmac. Chemother.
24, 538 - 548, 1965.10. Modification by drugs of the metabolism of 3,4-dihydroxyphenylethylamine,
noradrenaline and 5-hydroxytryptamine in the brain.
By R. Laverty and D. F. Sharraan. Br. J. Pharmac. Chemother. 24.
759 - 772, 1965.11. The effect of drugs on the homovanillie aoid content of the corpus
striatum of some rodents. By A. V. Juorio, D. F. Sharman and T. Trajkov.
Br. J. Pharmac. Chemother. 26. 385 - 392, 1966.12. Changes in the metabolism of 3,4-dihydroxyphenylethylamine
(dopamine) in the striatum of the mouse induced by drugs. By D. F. Sharman,
Br. J. Pharmac. Chemother. 28. 153 - 163, 1966.13. A discussion of the modes of action of drugs which increase the
concentration of 4-hydroxy-3-methoxyphenylacetic acid (homovanillic
acid) in the striatum of the mouse. By D. P. Sharman. Br. J. Pharmac.
Chemother. 30, 620 - 626, 1967.14. Homovanillic acid and dihydroxyphenylacetic acid in the striatum
of monkeys with brain lesions. By D. P. Sharman, L. J. Poirier,
G. P. Murphy and T. L. Sourkes. Can. J. Physiol. Pharmacol. 49. 57 -
62, 1967.15. Release by tubocurarine of dopamine and homovanillic acid from
the superfused caudate nucleus. By P. J. Portig, D. P. Sharman and
Marthe Vogt. J. Physiol. Lond. 194. 565 - 572, 1968.16. The effect of tropolone on the formation of 3,4-dihydroxyphenylacetic
acid and 4-hydroxy-3-methoxyphenylacetic acid in the brain of
the mouse. By G. P. Murphy, D. Robinson and D. P. Sharman. Br. J.
Pharmac. Chemother. j>6, 107 - 115, 1969.17. Turnover of amines using probenecid to block the egress of
metabolites. By D. P. Sharman. Metabolism of brain amines. Edited
by G. Hooper, Macmillan, London, pp. 34 - 37, 1969.These papers form the main part of the thesis and attempt to relate
the concentration of HVA in the central nervous system to the rate at
which dopamine is utilised in this tissue. The locus of the metabolism
of dopamine in the central nervous system is discussed.The papers in the third group are concerned with noradrenaline
or its glycol metabolites.18. Noradrenaline content in the heart and spleen of the mouse tinder
normal conditions and after administration of some drugs.
By D. P. Sharman, S. Vanov and Marthe Vogt. Br. J. Pharmac. Chemother.
11, 527 - 533, 1962.This study was made to investigate a report of what appeared to he
unusual behaviour of the tissue catecholamines in the mouse. The method
used to estimate the noradrenaline was designed to incorporate as many
controls as was possible to ensure that correct estimates were obtained.
The earlier report could not be confirmed.19. Iontophoretic release of adrenaline noradrenaline and 5-hydroxytryptamine
from raicropipettes. By K. Krnjevic, R. Laverty and D. P.
Sharman. Br. J. Pharmac. Chemother. 20, 491 - 496, 1963.Fluorimetric methods were used to measure the relation between the
release of these amines and the electrical charge applied to micropipettes
used for the iontophoretic application of drugs to single
neurones.20. The action of 2,4,5-trihydroxyphenylethylamine on the storage and
release of noradrenaline. By R. Laverty, D. P. Sharman and Marthe Vogt.
Br. J. Pharmac. Chemother. 24, 549 - 560, 1965.2,4,5-Trihydroxyphenylethylamine causes a rapid and long lasting
depletion of noradrenaline from the mouse heart. A new method was
developed for the estimation of the former amine and was used to show
that it did not persist in the tissue or was tightly bound in the tissue.21. The noradrenaline content of the caudate nucleus of the rabbit.
By D. P. Sharman and Marthe Vogt. J. Neurochem. 12. 62, 1965.This short paper illustrates a frequently reported erroneous result
when a commonly used fluorimetric method for the estimation of nor-adrenaline is applied to those brain tissues which contain very little
of this amine.22. Gas chromatographic evidence for the presence of glycol metabolites
of catecholamines in brain tissue. By B. F. Sharman. J. Physiol. Lond.
200. 35 - 35P, 1969.23. Glycol metabolites of noradrenaline in brain tissue.
By D. P. Sharman. Accepted for publication by Br. J. Pharmac.
Chemother. 1969.The application of gas liquid chromatography and electron capture
detection to the estimation of glycol metabolites of noradrenaline in
the brain is described. The possibility of using a similar technique
for the estimation of noradrenaline and normetanephrine is discussed.These two papers describe the estimation of noradrenaline, dopamine,
5-hydroxytryptamine and acetylcholine in particles obtained by sub-cellular fractionation of brain tissues. The first shows that
dopamine is associated with a particle that is similar to,but distinguish¬
able from, that with which acetylcholine is associated. The second paper
demonstrates that the storage sites within subcellular particles for
acetylcholine and those for noradrenaline and 5-hydroxytryptamine
are different
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
- …
