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The IAAF’s hyperandrogenism regulations suspended
No full textOn 27 July, the Court of Arbitration for Sport (‘CAS’) delivered a landmark ruling on the regulation of gender in sport. The decision explores how the categorisation of sport on the basis of sex can be best reconciled with the “biological reality” that human sex cannot necessarily be divided so clearly. Dr. Seema Patel, Senior Lecturer at Nottingham Trent University, Deputy Director of the Centre for Sports Law and author of ‘Inclusion and Exclusion in Competitive Sport: Socio-Legal and Regulatory Perspectives,’ reviews the case and suggests that sport regulation must be cautious of traditional criteria to determine eligibility in sports
ECOLOGICAL ANALYSIS OF LITERACY IN RAJASTHAN: AN APPLICATION IN SOCIAL GIS
No full textUrmi Sharma 1, Seema Jalan2 and Purnima Singh3 1 Assistant Professor, 2Professor, Department of Geography, MLS University, Udaipur (Rajasthan) India 3Assistant Professor, Govt. Meera Girls' College, Udaipur (Rajasthan) India Email: [email protected]
Jun N-terminal kinase 1 (JNK1) as a molecular target to limit cellular mortality under hypoxia
No full textMany pathological conditions and environmental impacts lead to a decrease in tissue oxygen supply and severe cellular hypoxia. This secondary hypoxia can disturb cellular homeostasis, limiting the efficacy of the prescribed treatment for the primary disease, eventually leading to cellular and organismal death. Jun N-terminal kinase 1 (JNK1) plays a central role in the development of cellular damage under hypoxia, hypoxia/reoxygenation and ischemia/reperfusion conditions. Therefore, we selected JNK1 protein as a molecular target to limit cellular damage and death during hypoxia. The primary objective of this research was to study the influence of the suppression of JNK1 on the development of cellular hypoxic damage. It was hypothesized that suppression of JNK1 will decrease cellular mortality under hypoxia and may increase the efficacy of traditional treatment of many pathological conditions. The hypothesis was verified under both in vitro and in vivo conditions. Another objective was to develop a non-viral system for intracellular delivery of antisense oligonucleotides (ASO) and small interfering RNA (siRNA). ASO and siRNA targeted to JNK1 mRNA delivered by neutral and cationic liposomes, respectively, showed high efficiency in suppressing JNK1 protein. Such suppression limited the caspase dependent apoptosis signaling pathway and decreased cellular mortality induced by severe hypoxia. The results suggest that JNK1 protein might be an attractive target for antihypoxic therapy to increase resistance to many pathological conditions and diseases accompanied by cellular hypoxia.Ph.D.Includes bibliographical references (p. 138-153)by Seema S. Betiger
Bilateral rhegmatogenous retinal detachments: clinical profile and outcome of 122 eyes
No full text<p>Bilateral rhegmatogenous retinal detachments: clinical profile and outcome of 122 eyes. Monika Kapoor, Koushik Tripathy, Rohan Chawla, Ravi Bypareddy, Laxman Vekaria, Yog Raj Sharma, Seema Meena<br>15th EURETINA Congress - Nice 2015 17 - 20 September 2015 in Acropolis, Nice, France.<br>2015-09 | conference-abstract</p>
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The Post Office Horizon system and Seema Misra
Get PDFThe author highlights the significance of the Seema Misra case in raising questions about the reliablity of the Post Office Horizon system and more widely suggesting that all digital systems have the possibility of latent defects, and these can never be discounted. He argues that when the efficacy of digital systems is called into question in legal proceedings, the onus of proof must be placed on the supplier of these systems and not the accuser.Index words: Post Office; Horizon; prosecutions; software errors; disclosure Full transcript of the trial Regina v Seema Misra, T2009007 (England & Wales; theft; electronic evidence; Post Office Horizon System; ‘reliability’ of computers) with case commentary and index to original papers held in the Documents Supplement of Volume 12: 2015
Impact of fiscal policy shocks on the Indian economy
Get PDFImpact of Fiscal Policy Shocks on the Indian Economy Swati Yadav , V.Upadhyay , Seema Sharma Abstract In this paper, we analyse the impact of fiscal shocks on the Indian economy using structural vector autoregression (SVAR) methodology. The study uses quarterly data for the period 1997Q1 to 2009Q2. Two different identification schemes have been used to assess the effects of shocks to government spending and tax revenues on output. The recursive scheme is based on the Cholesky decomposition and the second identification scheme Blanchard & Perrotti (1999) technique of using information on tax system to identify the SVAR model. We find that the impulse responses obtained from both identification schemes behave in a similar fashion but the value of multipliers differs. Also the shock to tax variable has a bigger impact on GDP than the government spending shock. In the extended four variable VAR model the effects of fiscal shocks on private consumption has been assessed using the recursive identification scheme. Findings indicate that the tax variable has larger impact on private consumption as compared to the government spending variable. In the short run the impact of expansionary fiscal shocks follow Keynesian tradition but the long run response is mixed.SVAR, Fiscal shocks, Multipliers
Impact of fiscal policy shocks on the Indian economy
Get PDFImpact of Fiscal Policy Shocks on the Indian Economy
Swati Yadav , V.Upadhyay , Seema Sharma
Abstract
In this paper, we analyse the impact of fiscal shocks on the Indian economy using structural vector autoregression (SVAR) methodology. The study uses quarterly data for the period 1997Q1 to 2009Q2. Two different identification schemes have been used to assess the effects of shocks to government spending and tax revenues on output. The recursive scheme is based on the Cholesky decomposition and the second identification scheme Blanchard & Perrotti (1999) technique of using information on tax system to identify the SVAR model. We find that the impulse responses obtained from both identification schemes behave in a similar fashion but the value of multipliers differs. Also the shock to tax variable has a bigger impact on GDP than the government spending shock. In the extended four variable VAR model the effects of fiscal shocks on private consumption has been assessed using the recursive identification scheme. Findings indicate that the tax variable has larger impact on private consumption as compared to the government spending variable. In the short run the impact of expansionary fiscal shocks follow Keynesian tradition but the long run response is mixed
Development of novel zein-cellulose nanocomposite films
No full textZein is a hydrophobic biopolymer, which naturally forms biodegradable films. These films are rigid, brittle, and lack good mechanical and barrier properties for packaging applications. This study aims at improving the mechanical and barrier properties of zein films by the development of zein-cellulose nanocomposites. A ‘nanocomposite’ is a mixture of polymer matrix, which forms the continuous phase and the filler (having at least one dimension less than 100nm), which forms the dispersed phase. Zein-cellulose nanocomposites have zein as the matrix and cellulose as the filler. Nano-sized cellulose was prepared using wet-media milling machine and mass ratios of 1%, 3%, 5% and 10% of both, naked (not stabilized) nano-cellulose and GA - stabilized nano-cellulose were used in the film formulation. Tributyl citrate (TBC) was used as the plasticizer. The films were prepared using solvent-cast technique and characterized to test their mechanical and barrier properties. The controls were pure zein films and films with only plasticizer. Texture Analysis showed that filler loading of 5% was most effective in increasing the elongation-at-break to about 16 to 20 times of the controls. However, the tensile strength did not change. Water vapor permeability of the nanocomposites was minimum at 1% by wt. of naked cellulose (~4 times less than control) or at 5% by wt. of stabilized cellulose (~6 times less than control). Water absorption results showed that the rate of water uptake decreased as the filler loading increased. DSC and FTIR suggested that there is no interaction between the zein and the nano-cellulose in the films. The AFM results showed that the films’ surface is flat, but the thickness of the films increased with filler loading. Therefore, incorporation of nano-cellulose improved the flexibility and water barrier properties of the films. Gum Arabic, which was used as a stabilizer for nano-cellulose, seemed to have aided the even distribution of cellulose in the zein matrix. Thus, these films can be a good starting point to further study the arrangement of cellulose within the zein matrix and test its potential applications on food systems and as edible films.M.S.Includes bibliographical referencesby Seema Lakshmana Ra
Allergic aspergillosis and the antigens of Aspergillus fumigatus
No full textIncidence of fungal infections has increased alarmingly in past few decades. Of the fungal pathogens, the Aspergillus fumigatus has been a major cause of allergic bronchopulmonary aspergillosis (ABPA) which has five main stages - the acute, remission, exacerbation, glucocorticoid dependent and fibrotic stage. The diagnosis of ABPA remains difficult due to its overlapping clinical and radiological features with tuberculosis and cystic fibrosis. From past few decades, the crude fractions of A. fumigatus have been used for immunodiagnosis of ABPA. Most of the detection kits based on crude fractions of A. fumigatus are quite sensitive but have low specificity. Till date 21 known and 25 predicted allergens of A. fumigatus have been identified. Of these allergens, only five recombinants (rAsp f1-f4 and f6) are commercially used for diagnosis of allergic aspergillosis. Remaining allergens of A. fumigatus have been restricted for use in specific diagnosis of ABPA, due to sharing of common antigenic epitopes with other allergens. Complete sequencing of A. fumigatus genome identified 9926 genes and the reports on the proteome of A. fumigatus have shown the presence of large number of their corresponding proteins in the pathogen. The analysis of immunoproteomes developed from crude fractions of A. fumigatus by IgG/IgE reactivity with ABPA patients and animal sera have identified the panel of new antigens. A brief description on the current status of A. fumigatus antigens is provided in this review. The implementation of advance recombinant expression and peptidomic approaches on the A. fumigatus antigens may help in the selection of appropriate molecules for the development of tools for more specific early diagnosis of ABPA, and desensitization therapies for patients of allergic disorders
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