4,999 research outputs found
Cardiac disease
No full textPresented by Nova Southeastern University; hosted by Fred Lippman, R.Ph., Ed.D. Chancellor Health Professions Division; with guests Ashok K. Sharma, M.D., FACC; Medical Director; Broward Heart Specialists; and Aryama D. Sharma, M.D., P.A.; Gastroenterology and Hepatology, Westside Medical Park, Plantation
Simple drag prediction strategies for an Autonomous Underwater Vehicle’s hull shape
No full textThe range of an AUV is dictated by its finite energy source and minimising the energy consumption is required to maximise its endurance. One option to extend the endurance is by obtaining the optimum hydrodynamic hull shape with balancing the trade-off between computational cost and fluid dynamic fidelity. An AUV hull form has been optimised to obtain low resistance hull. Hydrodynamic optimisation of hull form has been carried out by employing five parametric geometry models with a streamlined constraint. Three Genetic Algorithm optimisation procedures are applied by three simple drag predictions which are based on the potential flow method. The results highlight the effectiveness of considering the proposed hull shape optimisation procedure for the early stage of AUV hull desig
Changes in immunolocalisation of ?-dystroglycan and specific degradative enzymes in the osteoarthritic synovium
No full textOBJECTIVE: To investigate the immunolocalisation of ?-dystroglycan (?-DG) and specific matrix metalloproteinases (MMPs)-3, -9, -13 and a disintegrin like and metalloproteinase thrombospondin type 1 motif 4 (ADAMTS-4) within the joint tissues of patients with osteoarthritis (OA) and unaffected controls. DESIGN: Cartilage, synovium and synovial fluid were obtained from the hip joints of five osteoarthritic (patients undergoing total hip replacement) and five control hip joints (patients undergoing hemiarthroplasty for femoral neck fracture). The samples were analysed for ?-DG protein using Western blot technique and by immunohistochemistry for tissue distribution of ?-DG, MMP-3, -9, -13, and ADAMTS-4. RESULTS: ?-DG was detected in the smooth muscle of both normal and osteoarthritic synovial blood vessels. Importantly, ?-DG was detected in endothelium of blood vessels of OA synovium, but not in the control endothelium. In the endothelium of osteoarthritic synovial blood vessels, ?-DG co-localised with MMP-3 and -9. MMP-13 and ADAMTS-4 showed no endothelial staining, and only weak staining of the vascular smooth muscle was found. In contrast, we did not detect ?-DG protein in cartilage or synovial fluid. CONCLUSIONS: ?-DG has been shown to have a role in angiogenesis, and our results demonstrate for the first time that there are clear differences in ?-DG staining between OA and control synovial blood vessels. The specific immunolocalisation of ?-DG within endothelium of inflamed OA blood vessels and its co-localisation with MMP-3 and -9, reported to have pro-angiogenic roles and believed to be involved in ?-DG cleavage, may also suggest that ?-DG plays a role in angiogenesis accompanying OA
THE CORRELATION OF THE MEDIEVAL EUROPEAN STATE AND LAW IN THE DOCTRINE OF P.A. KROPOTKIN
Get PDFThe actual task of Russian state studies and jurisprudence remains the opposition to the ideological and theoretical constructions of Russian classical anarchism. Purpose: to establish the most significant features and disadvantages of P.A. Kropotkin’s interpretation of the correlation of state and law on the example of Medieval Europe. When writing the article, the author applies interdisciplinary and class approaches. General scientific and specific scientific methods are used: historical, problem-theoretical, formal-logical, textual. Materials: monuments of law, other historical sources, foreign and national historiography. The analysis shows that P.A. Kropotkin’s works are characterised not only by a pronounced anti-exploitation pathos, but also by an equally pronounced tendentiousness. Results: aprioriism, anti-statism and antilegism, radical localism, Eurocentrism, diffusionism, cyclism and catastrophism, clothed in the form of postulates, predetermined P.A. Kropotkin’s one-sided interpretations of the interaction of the medieval European state with positive and customary law. In the first case, it took a purely causative form, and in the second, it was predominantly conflictual. These are the key flaws of P.A. Kropotkin’s correlation concept
Flow-induced gate vibrations: Prevention of sef-excitation computation of dynamic gate behaviour and the use of models
No full textThe objective of this study is to develop design criteria for the dynamic behaviour of gates and valves. To this end, a resume of existing theories is given as well as an extended analysis of the added water mass, hydrodynamic rigidity and damping (also negative damping or self-excitation) and excitation by turbulent flow. New computation methods are presented for self-exciting vibrations: The ensuing introduction of an instability indicator permits the prediction of such vibrations in the design phase. Methods are described to calculate the added water mass and water damping in flowing water. Also treated are the instability of overflowing and falling water nappes, the response of a mass-spring system to noise excitation by turbulence, and the technique of hydroelastic models. Prior publications by the author on these subjects are to be found in the Appendices.Hydraulic EngineeringCivil Engineering and Geoscience
Quality and qualities of design studies, design research and design
No full textGreen Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Methodologie en Organisatie van Desig
Views of P.A. Krushevan on the National Problem in Russia: Moldavian or Russian Nationalist
No full textThe article deals with the national identity of P.A. Krushevan. Being of Moldavian nationality, he was a Russian conservative writer and journalist. At the beginning of the 19th century he served as a Russian nationalist in the political arena. The author shows that he was a supporter of Moldavian national traditions and a personality of the Moldavian national movement. At the same time Krushevan was an «imperial nationalist» and a Russian statesman. In behalf of Bessarabia peasants, he exposed the economic activity of «plutocracy», but he was a stranger to domestic anti-Semitism
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