124 research outputs found
Prevalence of Transfusion Transmitted Infections among Blood Donors in Madhya Pradesh, a Central State of India
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Pseudolycorine <i>N</i>-oxide, a new <i>N</i>-oxide from <i>Narcissus tazetta</i>
No full textA new N-oxide, Pseudolycorine N-oxide (1) was characterised along with eleven known alkaloids homolycorine (2), O-methylmaritidine (3), 8-O-demethylhomolycorine (4), homolycorine N-oxide (5), lycorine (6), narciclasine (7), pseudolycorine (8), ungeremine (9), 8-O-demethylmaritidine (10), zefbetaine (11) and lycorine N-oxide (12), from Narcissus tazetta. Their structures were established on the basis of spectroscopic data analysis. The extract, fractions and isolated compounds were screened for in vitro cytotoxicity against two human cancer cell lines, human cervical cancer (SiHa) and human epidermoid carcinoma (KB) cells. The study demonstrated the cytotoxic potential of extract and its chloroform and n-butanol fractions. Further, the results revealed the bioactive potential of narciclasine, pseudolycorine and homolycorine alkaloids. However, new N-oxide (1) was not active against these cell lines.</p
Silicon Shadow Mask Technology for Aligning and In Situ Sorting of Semiconducting SWNTs for Sensitivity Enhancement: A Case Study of NO2 Gas Sensor
No full textSilicon Shadow Mask Technology for Aligning and In Situ Sorting of Semiconducting SWNTs for Sensitivity Enhancement: A Case Study of NO2 Gas Sensor
No full textSingle-walled carbon nanotubes (SWNTs) are incorporated in different device configurations such as chemiresistors and field-effect transistors (FETs) as a sensing element for the fabrication of highly sensitive and specific biochemical sensors. For this purpose, sorting and aligning of semiconducting SWNTs between the electrodes is advantageous. In this work, a silicon shadow mask fabricated using conventional semiconductor processes and silicon bulk micromachining was used to make metal contacts over SWNTs with a minimum feature of 1 μm gap between the electrodes. The developed silicon shadow mask-based metal contact patterning process is cost-effective and free from photoresist (PR) chemical coatings and thermal processing. After a detailed investigation, sodium dodecyl sulfate (SDS), an anionic surfactant, along with ultrasonication process, was found to be effective for the removal of unclamped and metallic SWNTs, resulting in aligned and clamped semiconducting SWNTs between the electrodes. The presence of aligned semiconducting SWNTs was confirmed using atomic force microscopy (AFM), field emission scanning electron microscopy (FESEM), and Raman spectroscopy techniques. The fabricated devices were tested for nitrogen dioxide (NO2) gas sensing as a test case. The sensitivity enhancement of ∼21 to 76% in the 20-80 ppm NO2 concentration range has been observed in the case of aligned semiconducting SWNT devices compared to the random network SWNT-based sensors
Zephgrabetaine: A New Betaine-type Amaryllidaceae Alkaloid from Zephyranthes grandiflora
No full textZephgrabetaine (1), a new betaine type Amaryllidaceae alkaloid, along with seven known alkaloids, lycorine, galanthine, lycoramine, hamayne,
haemanthamine, tortuosine, and ungeremine were isolated from the bulbs of Zephyranthes grandiflora and their structures elucidated by spectroscopic data
analysis. The isolated alkaloids were tested for in vitro cytotoxic activities against two cell lines, C-6 (rat glioma cells) and CHO-K1 (Chinese hamster ovary
cells). A dose dependent cytotoxic effect was exhibited by all the alkaloids on these two cancer cell lines with prominent activity of lycorine and
haemanthamine
Narciclasine-4-<i>O</i>-<i>β</i>-D-xylopyranoside, a new narciclasine glycoside from <i>Zephyranthes minuta</i>
No full textA new narciclasine glycoside, narciclasine-4-O-β-D-xylopyranoside (1) was characterised along with four known alkaloids pancratistatin (2), 1-O-(3-hydroxybutyryl) pancratistatin (3), vittatine (4), 9-O-demethylgalanthine (5) from Zephyranthes minuta. Their structures were established on the basis of spectroscopic data analysis. The in vitro cytotoxic study of extract, fractions and isolated compounds against two human cancer cell lines (KB and SiHa) indicated the potential activity of extract and n-butanol fraction due to presence of active alkaloids pancratistatin, 1-O-(3-hydroxybutyryl) pancratistatin, lycorine and haemanthamine.</p
Assessing Medical Device Risks in Radiology Departments: A Critical Review
No full textBackground: This study explores radiologists’ perceptions of risks associated with medical devices in radiology departments within hospitals in Saudi Arabia. Given the increasing use of advanced medical technologies and devices in the healthcare sector, it is important to understand how healthcare professionals, particularly radiologists, perceive and manage these risks.
Methods: A total of 257 radiologists from hospitals across Saudi Arabia participated in the study. Data were collected through a self-administered online questionnaire designed to assess their perceptions of risk management practices and the effectiveness of current risk control measures in radiology departments. The data collected were analyzed using the Statistical Package for the Social Sciences (SPSS) to identify key trends and insights regarding the management of risks associated with medical devices in radiology.
Results: The results indicate that while most radiologists perceive their department's risk management systems to be effective, several areas need improvement. Many participants reported that formal risk management systems and committees are in place to oversee the control of medical device risks, but there are challenges in terms of policy clarity and the overall effectiveness of MoH regulations. Furthermore, predictive risk models were found to be used more frequently for electrical and overwork risks, while radiation dose risks were addressed less frequently.
Conclusion: The study reveals a generally positive perception of risk management practices among radiologists in Saudi Arabia, but gaps remain in policy clarity, risk prediction practices, and implementation. The results suggest that improving communication, improving the effectiveness of risk management policies, and increasing training and awareness of healthcare professionals could help mitigate risks associated with medical devices in radiology departments. These improvements could lead to safer healthcare environments and better patient outcomes
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