59 research outputs found
Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation
No full textDeficiency of vitamin D is associated with accelerated decline in lung function. Vitamin D is a ligand for nuclear hormone vitamin D receptor (VDR), and upon binding it modulates various cellular functions. The level of VDR is reduced in lungs of patients with chronic obstructive pulmonary disease (COPD) which led us to hypothesize that deficiency of VDR leads to significant alterations in lung phenotype that are characteristics of COPD/emphysema associated with increased inflammatory response. We found that VDR knock-out (VDR(-/-)) mice had increased influx of inflammatory cells, phospho-acetylation of nuclear factor-kappaB (NF-κB) associated with increased proinflammatory mediators, and up-regulation of matrix metalloproteinases (MMPs) MMP-2, MMP-9, and MMP-12 in the lung. This was associated with emphysema and decline in lung function associated with lymphoid aggregates formation compared to WT mice. These findings suggest that deficiency of VDR in mouse lung can lead to an early onset of emphysema/COPD because of chronic inflammation, immune dysregulation, and lung destruction
Upwelling-induced variability of chlorophyll in the Taiwan Strait as observed by SeaWiFS and AVHRRR
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Smoothed Particle Hydrodynamics Simulation of a Mariculture Platform under Waves
No full textThis work investigates the dynamic behaviors of floating structures with moorings using open-source software for smoothed particle hydrodynamics. DualSPHysics permits us to use graphics processing units to recreate designs that include complex calculations at high resolution with reasonable computational time. A free damped oscillation was simulated, and its results were compared with theoretical data to validate the numerical model developed. The simulated three degrees of freedom (3-DoF) (surge, heave, and pitch) of a rectangular floating box have excellent consistency with experimental data. MoorDyn was coupled with DualSPHysics to include a mooring simulation. Finally, we modelled and simulated a real mariculture platform on the coast of China. We simulated the 3-DoF of this mariculture platform under a typical annual wave and a Typhoon Dujuan wave. The motion was light and gentle under the typical annual wave but vigorous under the Typhoon Dujuan wave. Experiments at different tidal water levels revealed an earlier motion response and smaller motion range during the high tide. The results reveal that DualSPHysics combined with MoorDyn is an adaptive scheme to simulate a coupled fluid–solid–mooring system. This work provides support to disaster warning, emergency evacuation, and proper engineering design
Unusual Fish Assemblages Associated with Environmental Changes in the East China Sea in February and March 2017
No full textTwo large fish assemblages were recorded in the overwintering fishing grounds of the East China Sea in February and March 2017. In this study, available time series of satellite-derived sea surface temperature, wind, chlorophyll a, and reanalysis data were used to explore the relationships between the observed large fish aggregations and environmental factors. The bottom waters of the fishing grounds were abnormally warm in winter 2017, and then experienced significant cooling due to the eastward movement of the Yellow Sea Cold Current, which was driven by the increased northwesterly wind from January to mid-March 2017. Fishing areas in the affected region, including No. 1891, which was abnormally warm, and No. 1592, which had a strong thermal front and high chlorophyll a concentration, might have provided suitable environments for the warm-temperature fish, resulting in the observed large fish assemblages. The abnormal temperature changes between winter and early spring 2017 may have been associated with changes in local ocean circulation
The Supplementary and Exact Solution of an Equivalent Mechanical Model for Fluid Sloshing in Nuclear Structure
No full textRapid evaluation method of subgrade performance using Portable Falling Weight Deflectometer
No full textThe performance evaluation of new and old subgrades is critical for the quality and safety of reconstruction and extension projects. It is necessary to achieve rapid and easy performance testing. In this study, a Portable FallingWeight Deflectometer (PFWD) is chosen to rapid evaluate the performance of subgrade. First, a testing area, the reconstruction and expansion project of the Hefei to Dagudian section of the Shanghai-Shaanxi Expressway, is selected. Then, the PFWD modulus Ep of resilient tested by PFWD and the corresponding water content w and compacting degree K tested by the cutting ring method for old subgrade are obtained. And the correlation relationship between Ep and w and K is established. The performance of old subgrade can be rapid obtained by PFWD. Meanwhile, for the new subgrade, the correlation relationship between Ep and bending value L, w and K is established, and the performance can also be rapid tested by PFWD. Finally, a rapid evaluation method for the reconstruction and expansion of subgrade performance was proposed, which aims to provide technical support for ensuring construction quality and safety and provides a technical reference and a theoretical basis for the prediction of similar subgrade performance
Tide-Surge-Wave Interaction in the Taiwan Strait during Typhoons Soudelor (2015) and Dujuan (2015)
No full textTyphoons Soudelor (2015) and Dujuan (2015) were two of the strongest storms to affect the Taiwan Strait in 2015. This study investigated the response of the waters on the western bank of the Taiwan Strait to the passage of Soudelor and Dujuan. This included an investigation of the resonant coupling between the tide and storm surge, typhoon wave variation caused by the storm tide, and wave-induced water level rise. Analyses conducted using numerical model simulations and observations from tidal stations and buoys, obtained during the passage of both Soudelor and Dujuan, revealed that resonant coupling between the astronomical tide and storm surge in the Taiwan Strait was prominent, which resulted in tidal period oscillation on the storm surge and reduced tidal range. The tide wave arrived earlier than the predicted astronomical tide because of the existence of the storm surge, which was attributable to acceleration of the tidal wave caused by the water level rise. Wave height observations showed that the storm tide predominantly affected the waves, which resulted in wave heights that oscillated within the tidal period. Numerical experiments indicated that both the current and the water level affected wave height. Waves were affected mainly by the current in the middle of the Taiwan Strait, but mostly by water level when the water level was comparable with water depth. Wave setup simulations revealed that wave setup also oscillated within the tidal period, and that local bathymetry was the most important influencing factor of wave setup distribution
A Hydraulic Reciprocating Rod Seal’s Life Evaluation Method Incorporating Failure Mechanism Analysis and Test Observation Data
No full textReciprocating rod seals are widely used in hydraulic systems. Their useful life and reliability affect that of the system. Degradation modeling is necessary to evaluate the useful life of the seal. Seal wear is one of the important forms of hydraulic reciprocating rod seal degradation, yet it is difficult to measure through direct methods. Because seal wear determines the leakage of the seal, we therefore consider the seal leakage as the performance degradation index. Furthermore, the degradation of the seal is always associated with random effects, which cannot be considered by theoretical failure mechanism analysis. Hence, stochastic processes are applied to consider the random effects. Considering the error between the measured value and its real degradation state caused by the measurement environment or other factors, we introduce the measurement error term into the Wiener process model and develop the corresponding Wiener process life prediction model. Finally, the failure mechanism analysis and test measurement data are fused to predict the life cycle of the hydraulic reciprocating rod seals. The effectiveness of the proposed method is verified by comparing the predicted degradation and the experimental observations
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